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Links from GEO DataSets

Items: 6

1.
Full record GDS5615

Oral histone deacetylase inhibitor ST7612AA1 effect on diffuse large B-cell lymphoma in vitro models

Analysis of lymphoma cell lines DOHH2 (derived from GCB-DLBCL) and TMD8 (derived from ABC-DLBCL) exposed to ST7612AA1 (300nM) for 8 hrs. ST7612AA1 is an oral thiol-based histone deacetylase inhibitor (HDACi). Results provide insight into the molecular mechanisms underlying ST7612AA1 action in DLBCL.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 cell line sets
Platform:
GPL10558
Series:
GSE62460
12 Samples
Download data
2.

Preclinical antitumor activity of ST7612AA1: a novel second generation oral histone deacetylase (HDAC) inhibitor

(Submitter supplied) assess the efficacy of ST7612AA1 oral pan-histone deacetylase inhibitor (HDACi), with respect to various solid and haematological tumors, and to characterize its mechanism of action
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5615
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE62460
ID:
200062460
3.

H3K9K14ac ChIP-chip in lung cancer cells treated with histone deacetylase inhibitor

(Submitter supplied) Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic strategy for advanced non-small cell lung cancer (NSCLC) is limitedly effective. In addition, validated histone deacetylase (HDAC) inhibitors for the treatment of solid tumors remain to be developed. Here, we propose a novel HDAC inhibitor, OSU-HDAC-44, as a chemotherapeutic drug for NSCLC. OSU-HDAC-44 was a pan-HDAC inhibitor and exhibits 3-4 times more effectiveness than suberoylanilide hydroxamic acid (SAHA) in suppressing cell viability in various NSCLC cell lines. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL7408
6 Samples
Download data: PAIR, TXT
Series
Accession:
GSE20304
ID:
200020304
4.

Gene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors

(Submitter supplied) Histone deacetylases (HDACs) regulate gene expression. Inhibition of class I HDACs has been shown to inhibit cancer cell growth. Largazole, a new potent HDAC inhibitor, shows strong antitumor activity, presumably by modulating transcription of cancer relevant genes. We used microarray analysis of human HCT116 colorectal carcinoma cell line to determine the gene expression profile after largazole treatment in comparison with other HDAC inhibitors (FK228 and SAHA). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE22061
ID:
200022061
5.

Gene expression profiling of histone deacetylase inhibition in epithelioid sarcoma

(Submitter supplied) Epithelioid Sarcoma (ES) is a rare neoplasm uniquely comprised of cells exhibiting both mesenchymal and epithelial features. Having propensity for local and distant recurrence, it can pose a diagnostic dilemma secondary to pathologic complexity. Patients have dismal prognosis due to lack of effective therapy. HDAC inhibitors exhibit marked anti-tumor effects in various malignancies. Our studies demonstrate that pan-HDAC inhibitors constitute potentially novel therapeutics versus ES. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10904
12 Samples
Download data: TXT
Series
Accession:
GSE66800
ID:
200066800
6.

An immediate transcriptional signature predicts response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts

(Submitter supplied) Gene expression analysis of three sets of patient-derived T-ALL xenografted murine lines treated or not treated with Givinostat, to investigate the immediate anti-leukemic effects after 6 hours of in vivo treatment with this histone deacetylase inhibitor.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
33 Samples
Download data: CEL
Series
Accession:
GSE69346
ID:
200069346
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