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Links from GEO DataSets

Items: 20

1.
Full record GDS5620

H3K79 histone methyl transferase DOT1L inhibitor Compound 55 effect on breast cancer cells: dose response

Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor Compound 55 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 4 dose sets
Platform:
GPL10558
Series:
GSE56630
8 Samples
Download data
2.

Expression profiling of MDA-MB-231 breast cancer cells treated with DOT1L inhibitors and siDOT1L

(Submitter supplied) MDA-MB-231 cell line with relatively high DOT1L levels was treated with two potent, selective inhibitors of the DOT1L histone methyl transferase. These compounds can inhibit cells migration and invasion and induce differentiation. Here we provide expression profiling data of cells treated with two DOT1L inhibitors [1] [2], DOT1L siRNA (siDOT1L) or control.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS5619 GDS5620
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE56630
ID:
200056630
3.
Full record GDS5619

H3K79 histone methyl transferase DOT1L inhibitor EPZ004777 effect on breast cancer cells: dose response

Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor EPZ004777 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 4 dose sets
Platform:
GPL10558
Series:
GSE56630
8 Samples
Download data
4.

MLL-AF6 leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
10 Samples
Download data: CEL, WIG
Series
Accession:
GSE43069
ID:
200043069
5.

Expression data from a human MLL-AF6 positive AML cell line

(Submitter supplied) The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation system. The ML2 human MLL-AF6 positive leukemia cell line was used for gene expression profiling to assess the transctiptional profile in MLL-AF6 leukemias.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
1 Sample
Download data: CEL
Series
Accession:
GSE43068
ID:
200043068
6.

Expression data from MLL-AF6 positive leukemia cells

(Submitter supplied) The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation system.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL
Series
Accession:
GSE43067
ID:
200043067
7.

Genome wide mapping of histone 3 lysine 79 dimethylation in MLL rearranged and control human leukemia cell lines

(Submitter supplied) We report the genome wide distribution of H3K79 dimethylation in the human MLL-AF6 rearranged cell line ML2 as well as the human MOLM13 and HL60 cell lines
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
3 Samples
Download data: WIG
Series
Accession:
GSE43063
ID:
200043063
8.

Genome wide mapping of histone 3 lysine 79 dimethylation in MLL-AF6 murine leukemias

(Submitter supplied) We report the genome wide distribution of H3K79 dimethylation in mouse MLL-AF6 positive leukemias to assess whether this epigenetic mark drives MLL-target gene expression.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
3 Samples
Download data: WIG
Series
Accession:
GSE43062
ID:
200043062
9.

DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation

(Submitter supplied) Actively transcribed genes in mammals are decorated by H3K79 methylation, which is correlated with transcription levels and is catalyzed by the histone methyltransferase DOT1L. DOT1L is required for mammalian development, and the inhibition of its catalytic activity has been extensively studied for cancer therapy; however, the mechanisms underlying DOT1L’s functions in normal development and cancer pathogenesis remain elusive. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL19057
66 Samples
Download data: BW
10.

Expression Profiling of Mixed Lineage Leukemia Cells Treated with a Potent Small-Molecule DOT1L Inhibitor

(Submitter supplied) Cell lines bearing MLL translocations (MV4-11 and MOLM-13) were treated with a potent, selective inhibitor of the DOT1L histone methyl transferase. Treatment of MLL-rearranged cell lines with the DOT1L inhibitor selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Here we provide expression profiling data of cells treated with DOT1L inhibitor or vehicle control.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4290
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE29828
ID:
200029828
11.
Full record GDS4290

Small-molecule DOT1L inhibitor EPZ004777 effect on mixed lineage leukemia cells: time course

Temporal analysis of mixed lineage leukemia (MLL)-rearranged cell lines MV4-11 and MOLM-13 treated with EPZ004777, a potent inhibitor of DOT1L histone methyl transferase. EPZ004777 induces differentiation and apoptosis in MLL-rearranged cells. Results provide insight into role of DOT1L in MLL cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 cell line, 3 time sets
Platform:
GPL570
Series:
GSE29828
24 Samples
Download data: CEL
12.

Global gene expression analysis of Dot1l-deficient and control intestinal villus cells in mouse

(Submitter supplied) Methylation of H3K79 is associated with chromatin at expressed genes, though it is unclear if this histone modification is required for transcription of all genes. Recent studies suggest that Wnt-responsive genes depend particularly on H3K79 methylation, which is catalyzed by the methyltransferase DOT1L. Human leukemias carrying MLL gene rearrangements show DOT1L-mediated H3K79 methylation and aberrant expression of leukemogenic genes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: TXT
Series
Accession:
GSE41710
ID:
200041710
13.

DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL9185 GPL8321
10 Samples
Download data: CEL, TXT, WIG
Series
Accession:
GSE41543
ID:
200041543
14.

H3K79me2 ChIP-seq in mouse proximal intestinal Lgr5(hi) stem cells and villus cells

(Submitter supplied) H3K79me2 ChIP-seq in mouse proximal intestinal Lgr5(hi) stem cells and villus cells
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9185
4 Samples
Download data: WIG
Series
Accession:
GSE41542
ID:
200041542
15.

Expression data from mouse proximal intestinal epithelial Lgr5(hi) stem cells and differentiated villus cells (enterocytes from Atoh1 conditional knockout)

(Submitter supplied) We used microarrays to detail the differentail gene expression between intestinal Lgr5(hi) stem cells and differentiated cells
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE41541
ID:
200041541
16.

Cerebellar granular neurons (CGN) and progenitors (CGNP) upon DOT1L inhibition or cKO

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16570 GPL17021
34 Samples
Download data: BIGWIG, CEL
Series
Accession:
GSE101949
ID:
200101949
17.

H3K79me2 ChIP-seq in cerebellar granular neurons (CGN) and progenitors (CGNP) upon DOT1L inhibition with SGC0946 in vitro

(Submitter supplied) DOT1L as methyltransferase of H3K79 is implicated in brian development. Here, we further defined DOT1L function within the granular neurons during cerebellar development using ChIP-seq of H3K79 dimethylation of isolated cerebellar granular neurons and progenitors. Thereby we compared samples treated with a DOT1L inhibitor versus DMSO treated cells. The data sets reveals new important targets of DOT1L, which ensure a correct development of the cerebellum.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
16 Samples
Download data: BIGWIG
Series
Accession:
GSE101947
ID:
200101947
18.

Gene expression analysis of P3 Dot1l conditional knockout mice in the cerebellum and of cerebellar granular neuron progenitors (CGNPs) or cerebellar granular neurons (CGNs) isolated from P7 wt mice upon DOT1L inhibition

(Submitter supplied) DOT1L as methyltransferase of H3K79 is implicated in brian development. Here, we further defined DOT1L function in gene expression during cerebellar development using Microarrays. For that we generated Dot1l knockout mice using a Atoh-Cre driver line resulting in a Dot1l knockout within the cerebellum. The RNA of cerebellar tissue of the Dot1l knockout animals was thereby compared to controls. Additionally we compared the RNA levels of cultured CGNP and CGN samples treated with a DOT1L inhibitor versus DMSO treated cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
18 Samples
Download data: CEL, XLS
Series
Accession:
GSE101945
ID:
200101945
19.

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL5082 GPL5811 GPL8321
49 Samples
Download data: BAR, BED, CEL
Series
Accession:
GSE12363
ID:
200012363
20.

Genome-wide analysis of H3K79 dimethylation in MLL-AF4 leukemic bone marrow

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). ChIP-chip analysis demonstrated increased histone H3 Lysine 79 (H3K79) dimethylation that correlated with Mll-AF4 associated gene expression profiles in murine ALLs, and in human MLL-rearranged leukemias. In addition, human MLL-rearranged ALLs can be distinguished from other ALLs by their genome-wide H3K79 methylation profiles. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL5811
1 Sample
Download data: BAR, BED, BPMAP, CEL
Series
Accession:
GSE12362
ID:
200012362
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