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Links from GEO DataSets

Items: 9

1.
Full record GDS5622

Myelodysplastic syndrome disorder: bone marrow mesenchymal stromal cells

Analysis of bone marrow (BM) mesenchymal stromal cells from adult patients representing MDS subtypes RCMD (refractory cytopenia with multilineage dysplasia) and RAEB (refractory anemia with excess blasts). Results provide insight into molecular changes in the BM microenvironment contributing to MDS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL10558
Series:
GSE61853
14 Samples
Download data
2.

Gene expression analysis of bone marrow mesenchymal stromal cells from myelodysplastic syndrome (MDS) patients and normal controls

(Submitter supplied) Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal stem cell disorders. We hypothesize that gene expression changes in the bone marrow (BM) microenvironment might play a fundamental role in the development and progression of MDS. The goal of the present study is to investigate the differences in gene expression profiles of BM mesenchymal stromal cells (MSCs) between MDS patients and normal individuals, as well as between MDS subtypes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5622
Platform:
GPL10558
14 Samples
Download data: TXT
Series
Accession:
GSE61853
ID:
200061853
3.

RNA-seq analysis of HD and MDS MSCs and MSC-conditioned monocytes

(Submitter supplied) Altered bone marrow hematopoiesis and immune suppression is a hallmark of myelodysplastic syndrome (MDS). While the bone marrow microenvironment influences malignant hematopoiesis, the mechanism leading to MDS-associated immune suppression is unknown. We tested whether mesenchymal stromal cells (MSCs) contribute to this process. Here, we developed a model to study cultured MSCs from MDS patients compared to similar aged matched normal controls for regulation of immune function. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
18 Samples
Download data: TXT, XLSX
Series
Accession:
GSE140101
ID:
200140101
4.

Mesenchymal stem cells from myelodysplastic syndromes are functionally and genomically abnormal

(Submitter supplied) Myelodysplastic syndromes (MDS) are a group of clonal disorders of hematopoietic stem cells. Mesenchymal stem cells (MSC) are the progenitors of the Bone Marrow (BM) stroma and have been involved in the physiopathology of MDS. The presence of cytogenetic aberrations on MSC from MDS patients is controversial. The aim of the study is to characterize BM derived MSC from patients with MDS using: kinetic studies, immunophenotyping, fluorescent in situ hybridisation (FISH) analysis and genetic changes by array based comparative genomic hybridization (array-CGH). more...
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL6575
13 Samples
Download data: GPR
Series
Accession:
GSE10822
ID:
200010822
5.

TGFβ1-mediated functional inhibition of mesenchymal stromal cells in MDS and AML

(Submitter supplied) Mesenchymal stromal cells (MSC) are involved in the pathogenesis of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), but how they contribute to the expansion of malignant cells and hematopoietic failure is poorly understood. To further characterize the pathological phenotype we performed RNA sequencing of MSC from patients with MDS and AML. Data analysis revealed a specific molecular signature with a significant overlap of genes commonly deregulated in all MDS subtypes and in AML. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
12 Samples
Download data: TXT
Series
Accession:
GSE107490
ID:
200107490
6.

Azacitidine Modulates the Mesenchymal Stromal Cell Compartment in Myelodysplastic Syndromes

(Submitter supplied) Mesenchymal stromal cells (MSC) are crucial components of the bone marrow (BM) microenvironment essential for regulating self-renewal, survival and differentiation of hematopoietic stem/progenitor cells (HSPC) in the stem cell niche. MSC are functionally and phenotypically altered in myelodysplastic syndromes (MDS), contributing to disease progression. MDS MSC do not harbor recurrent genetic alterations but have been shown to exhibit an altered methylome compared to MSC from healthy controls. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
32 Samples
Download data: TXT
Series
Accession:
GSE112461
ID:
200112461
7.

Distinct Transcriptomic and Exomic Abnormalities within Myelodysplastic Syndrome Marrow Cells

(Submitter supplied) Prior studies using DNA microarray platforms have shown alterations of gene expression profiles (GEPs) of marrow cells in myelodysplastic syndromes (MDS). Using the increased sensitivity and accuracy of high-throughput RNA sequencing (RNA-Seq) for detecting and quantifying mRNA transcripts, our study has demonstrated novel significant differences in GEPs between MDS and normal CD34+ marrow cells with 41 genes identified as disease classifiers. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
67 Samples
Download data: TXT
Series
Accession:
GSE111085
ID:
200111085
8.

Gene expression profiling of CD34+ cells from MDS patients and normal controls

(Submitter supplied) In order to gain insight into the poorly understood pathophysiology of the myelodysplastic syndromes (MDS), we have determined the gene expression profiles of the CD34+ cells of 55 MDS patients using the Affymetrix GeneChip U133 Plus2.0 platform Keywords: Disease v normal
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2118
Platform:
GPL570
66 Samples
Download data
Series
Accession:
GSE4619
ID:
200004619
9.
Full record GDS2118

Myelodysplastic syndromes: CD34+ cells

Analysis of CD34+ cells from 55 patients with myelodysplastic syndromes (MDSs). MDSs are a heterogeneous group of hematopoietic malignancies, characterized by blood cytopenias, ineffective hematopoiesis, and a hypercellular bone marrow. Results provide insight into the pathophysiology of MDS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL570
Series:
GSE4619
66 Samples
Download data
DataSet
Accession:
GDS2118
ID:
2118
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