Similar studies for GEO DataSets (Select 5625) - GEO DataSets

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Items: 20

Select item 56251.

DNA methyltransferase inhibitor 5-aza-2’-deoxycytidine effect on oral cancer cell lines

Analysis of oral squamous cell carcinoma (OSCC) cell lines: OC3, SAS, SCC-15, and HSC3, treated with 5-aza-2’-deoxycytidine (AzC), an inhibitor of DNA methyltransferase. Results provide insight into potential tumor suppressor genes silenced by DNA hypermethylation in OSCC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 4 cell line sets

Platform:: GPL6883
Series:: GSE38823
16 Samples

Download data

DataSet

Accession:: GDS5625

ID:: 5625

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000452382.

Identification of oral carcinoma miRNA involved in Wnt/b-catenin signaling

(Submitter supplied) MicroRNAs (miRNAs) participate in many biological processes and have emerged as key players in carcinogenesis. In order to identify changes in miRNAs specific for betelquid-associated oral squamous cell carcinoma (OSCC), we investigated the expression profiles of 858 miRNAs in a panel of 40 pairs of OSCC specimens and their matched non-tumorous epithelial counterparts. Eighty-four miRNAs were differentially expressed in the OSCC specimens compared to the matched tissue. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8179
80 Samples

Download data: TXT

Series

Accession:: GSE45238

ID:: 200045238

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000388233.

Gene expression profiling of oral cancer cell lines with or without AzC treatment

(Submitter supplied) To genome-wide screening for the genes whose expression are responsible for the promoter DNA methylation, we performed the cDNA microarray with oral cancer cells before and after a DNA methyltransferase inhibitor, 5-aza-2’-deoxycytidine (AzC), treatment.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5625
Platform:: GPL6883
16 Samples

Download data: TXT

Series

Accession:: GSE38823

ID:: 200038823

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000379914.

Gene expression profiling of oral squamous cell carcinoma (OSCC)

(Submitter supplied) According to epidemiological studies, a vast majority, approximately 80%~90% of male OSCC patients in Taiwan habitually drink alcohol (A), and chew betel quid (B), and use cigarette (C). To assess the impact of these dietary factors on the transcriptom, we conduct a high-throughput screen survey in an oral cancer cohort with exposure of A, B, and C. Results indicate several potential oncogenes and tumor suppressor genes are dysregulated in OSCC patients with ABC risk factors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6883
80 Samples

Download data: TXT

Series

Accession:: GSE37991

ID:: 200037991

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000548615.

Gene expression profilings of normal human oral keratinocyte (HOK) and dysplastic oral keratinocyte cell line from a heavy smoker (DOK)

(Submitter supplied) In our previous study, we identified global genetic and epigenetic aberrations in the tumors of oral squamous cell carcinoma (OSCC) patients who were habitual smokers. We hypothesized that cigarette smoke might play a role in oral malignant transformation. DOK cell line is a dysplasitc oral keratinocyte derived from a heavy smoker with OSCC. The differentially expressed genes between DOK and normal human oral keratinocytes (HOK) may provide important information about OSCC carcinogenesis mediated by cigarette smoking.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE54861

ID:: 200054861

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000385326.

Methylation profiling of oral squamous cell carcinoma (OSCC)

(Submitter supplied) According to epidemiological studies, a vast majority, approximately 80%~90% of male OSCC patients in Taiwan habitually drink alcohol (A), and chew betel quid (B), and use cigarette (C). To assess the impact of these dietary factors on the epigenome, we conduct a high-throughput screen survey in an oral cancer cohort with exposure of A, B, and C. Results indicate aberrent methylation patterns are prevalent in OSCC patients with ABC risk factors.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
80 Samples

Download data: TXT

Series

Accession:: GSE38532

ID:: 200038532

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000454377.

Expression data from paediatric ependymoma short-term cell cultures

(Submitter supplied) Promoter hypermethylation and transcriptional silencing is a common epigenetic mechanism of tumour suppressor inactivation in cancer, including malignant brain tumours. To identify targets of epigenetic silencing mediated by CpG island methylation in paediatric ependymoma, we used a pharmacological unmasking approach through treatment with the demethylating agent 5-Aza-2’-deoxycytidine followed by global expression microarray analysis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE45437

ID:: 200045437

Select item 2001385878.

Target genes of miR-361-3p in human oral squamous cell carcinoma cells, GFP-SAS

(Submitter supplied) Inhibition of miR-361-3p by locked nucleic acid (LNA)/DNA antisense oligonucleotide markedly suppressed the growth of GFP-SAS cells. We explored the target genes of miR-361-3p in GFP-SAS cells using microarray analysis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
2 Samples

Download data: CEL

Series

Accession:: GSE138587

ID:: 200138587

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000870539.

Genome wide DNA methylation in oral squamous cell carcinoma (OSCC) disease and adjacent normal tissue samples

(Submitter supplied) Genome wide DNA methylation profiling of normal and adjacent OSCC samples. The Illumina Infinium 450k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 4,50,000 CpGs in tissue samples. Total 21 samples were taken including 10 paired and 1 unpaired tissues. 6 were HPV Positive and 5 were HPV negative.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
21 Samples

Download data: IDAT

Series

Accession:: GSE87053

ID:: 200087053

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007066610.

Integrated Profiling of mRNAs and microRNAs to Identify Potential Biomarkers for Oral Malignant Transformation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

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Series

Accession:: GSE70666

ID:: 200070666

PubMed Full text in PMC Similar studies

Select item 20007066511.

Integrated Profiling of mRNAs and microRNAs to Identify Potential Biomarkers for Oral Malignant Transformation [mRNA-Seq]

(Submitter supplied) The purpose of this study was to systematically profile the expression of both mRNAs and miRNAs in OSCC and its premalignant disease to identify some novel potential biomarkers for the detection of malignant transformation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: XLSX

Series

Accession:: GSE70665

ID:: 200070665

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20007066412.

Integrated Profiling of mRNAs and microRNAs to Identify Potential Biomarkers for Oral Malignant Transformation [miRNA-Seq]

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: XLSX

Series

Accession:: GSE70664

ID:: 200070664

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007018613.

TCF12 Expression Profiles in HNSCC

(Submitter supplied) To investigate the regulation of TCF12 on downstream genes in OSCC, we performed GeneChip analysis using OECM1 expression cell subclones and HSC3 knockdown cell subclones.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE70186

ID:: 200070186

Select item 20003185314.

Expression data from oral squamous cell carcinoma (OSCC)-derived cell lines and normal oral keratinocytes

(Submitter supplied) Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a result of local invasion and regional lymph node metastases. We used microarrays to identify down or upregulated genes in OSCCs compared with non-malignant controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4560
Platforms:: GPL570 GPL96
11 Samples

Download data: CEL, CHP

Series

Accession:: GSE31853

ID:: 200031853

Select item 456015.

Oral squamous cell carcinoma-derived cell lines

Analysis of oral squamous cell carcinoma (OSCC)-derived cell lines. OSCC is a lethal disease with early death typically occurring as a result of local invasion and regional lymph node metastases. Results provide insight the molecular mechanisms underlying OSCC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 9 cell line sets

Platform:: GPL96
Series:: GSE31853
9 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4560

ID:: 4560

Select item 20005112516.

Molecular characterization of 4-NQO induced F344 rat tongue carcinogenesis: alteration of multiple gene expression and hypomethylation of PTGS2 proximal promoter

(Submitter supplied) The 4-NQO induced rat tongue carcinogenesis model presenting considerable histologic and molecular similarity to oral cancers commonly seen in humans is very useful for investigating oral carcinogenesis. In order to understand the molecular basis of oral carcinogenesis and identify gene biomarkers and potential chemopreventive targets for future studies, we characterized the molecular changes in oral squamous cell carcinoma (SCC) samples generated from this model system using F344 rats by performing gene expression microarray and methylation analysis of selected genes. more...