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Links from GEO DataSets

Items: 5

1.
Full record GDS5627

Dasatinib-resistant and dasatinib-sensitive pancreatic cancer cell lines

Analysis of dasatinib-resistant and dasatinib-sensitive PC cell lines. Dasatinib, a small-molecule kinase inhibitor, is FDA-approved for PC, but certain PC cells can have intrinsic or acquired resistance to dasatinib. Results provide insight into molecular basis of dasatinib-resistance in PC cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 6 cell line, 2 cell type sets
Platform:
GPL10558
Series:
GSE59357
18 Samples
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2.

Gene expression profiles of dasatinib-resistant and dasatinib-sensitive pancreatic cancer cell lines

(Submitter supplied) Gene profiles from three dasatinib-resistant and three dasatinib-sensitive pancreatic cancer cell lines were compared by microarray analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5627
Platform:
GPL10558
18 Samples
Download data: TXT
Series
Accession:
GSE59357
ID:
200059357
3.

CDK-4 inhibitor P276-00 sensitizes Pancreatic Cancer cells to Gemcitabine induced Apoptosis

(Submitter supplied) Despite advances in molecular pathogenesis, pancreatic cancer remains a major unsolved health problem. It is a rapidly invasive, metastatic tumor that is resistant to standard therapies. The phosphatidylinositol-3-kinase (PI3K)/Akt and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in pancreatic cancer. Gemcitabine (Gem) is the mainstay treatment for metastatic pancreatic cancer. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15371
14 Samples
Download data: TXT
Series
Accession:
GSE36703
ID:
200036703
4.

A panel of hepatocellular carcinoma cell lines recapitulates the molecular subtypes of the human disease: A model for targeted drug development

(Submitter supplied) RNA expression patterns of liver cell lines were compared to those of liver tumors to determine the suitability of cell lines as a model for drug development studies. The cell lines appear to recapitulate liver tumors.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
20 Samples
Download data: TXT
Series
Accession:
GSE35818
ID:
200035818
5.

Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer

(Submitter supplied) Inhibition of SET by siRNA or SET antagonist and CIP2A by siRNA can downregulate c-MYC and c-MYC target genes.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
5 Samples
Download data: TXT
Series
Accession:
GSE58008
ID:
200058008
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