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Links from GEO DataSets

Items: 5

1.
Full record GDS5631

Lipopolysaccharide effect on scavenger receptor MARCO deficient-dendritic cells

Analysis of spleen dendritic cells (DCs) isolated from macrophage receptor with collagenous structure (MARCO)-knockout animals and cultured in media containing TLR agonist LPS. MARCO is part of the innate antimicrobial immune system. Results provide insight into the role of MARCO in activated DCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 protocol sets
Platform:
GPL11180
Series:
GSE55068
4 Samples
Download data: CEL
2.

Contribution of the scavenger receptor MARCO to TLR-induced activation of dendritic cells

(Submitter supplied) To gain additional insight into the role of MARCO in dendritic cell activation and function, we profiled transcriptomes of mouse splenic dendritic cells obtained from MARCO deficient mice and their wild type counterparts under resting and activating conditions.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5631
Platform:
GPL11180
4 Samples
Download data: CEL
Series
Accession:
GSE55068
ID:
200055068
3.

Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling

(Submitter supplied) Scavenger receptors on the cell surface of macrophages play an important role in host defence through their ability to bind microbial ligands and induce phagocytosis. Concurrently, signal transduction pathways are initiated that aid in defence mechanisms against the invading microbe. Here we report on the function of scavenger receptor Marco (macrophage receptor with collagenous structure) during infection of zebrafish embryos with Mycobacterium marinum, a close relative of Mycobacterium tuberculosis. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
4 Samples
Download data: TSV
Series
Accession:
GSE58230
ID:
200058230
4.

Dendritic cell stimulation: 5 ligands, 9 time points

(Submitter supplied) mouse primary BMDCs were stimulated with tlr ligands and gene expression changes were profiled on Affymetrix arrays
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8759
96 Samples
Download data: CEL
Series
Accession:
GSE17721
ID:
200017721
5.

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker

(Submitter supplied) Macrophages are the most common infiltrating immune cells in glioblastoma (GBM), and play a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of macrophages and their effects on the tumor microenvironment remain poorly understood. Here, we combine new and previously-published single-cell RNA-seq data from 86,279 single cells from a total of 63 gliomas to profile 17,774 individual macrophages. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
6 Samples
Download data: TXT
Series
Accession:
GSE141383
ID:
200141383
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