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Links from GEO DataSets

Items: 14

1.
Full record GDS5633

Peroxisome proliferator-activated receptor β/δ agonist and hypoxia effects on umbilical vein endothelial cells

Analysis of HUVECs stimulated with two important angiogenic stimuli: peroxisome proliferator-activated receptor (PPAR) β/δ agonist and hypoxia. Results provide insight into possible synergistic molecular interactions between the PPAR β/δ and hypoxia-inducible factor (HIF) 1 signaling pathways.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 stress sets
Platform:
GPL570
Series:
GSE50378
4 Samples
Download data: CEL
2.

Expression data of HUVEC cells after PPARβ/δ agonist and/or hypoxia treatment

(Submitter supplied) Recently the role of PPARβ/δ in angiogenesis has been revealed, and we hypothesized that the crosstalk between hypoxia and PPARβ/δ on endothelial cells may exsist. To elucidate the interaction between two signalings, we report the comprehensive change of transcripts induced by PPARβ/δ agonist (GW501516) and/or hypoxia. We used microarray analysis of HUVECs treated with PPARβ/δ agonist (GW501516) and/or hypoxia (1% O2) for 24-hours, and we identified a group of consistently up- or down-regulated genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5633
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE50378
ID:
200050378
3.

Genome-wide maps of H3K27ac, PPARβ/δ and Pol II localization in HUVECs

(Submitter supplied) H3K27Ac is one of the expressed enhancer markers, PPARβ/δ is a transcription factor and Pol II (RNA polymerase II) is an enzyme which catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. These genomic localization in endothelial cells is unknown in endothelial cells. This time, we established a new antibody for H3K27ac, PPARβ/δ and Pol II and performed ChIP-seq to identify H3K27ac, PPARβ/δ and Pol II binding site in whole genome manner under PPARβ/δ agonist and/or hypoxia.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL10999
22 Samples
Download data: WIG
Series
Accession:
GSE50144
ID:
200050144
4.

Genome-wide maps of H3K27ac localization in HUVECs

(Submitter supplied) H3K27Ac is one of the expressed enhancer markers in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for H3K27ac, and performed ChIP-seq to identify H3K27ac binding site in whole genome manner under hypoxia.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
2 Samples
Download data: BED, WIG
Series
Accession:
GSE38555
ID:
200038555
5.

Gene expression of wild-type and Ppar-beta null primary keratinocytes, with and without infection with an activated Hras retrovirus, with and without the Ppar-beta specific ligand GW0742

(Submitter supplied) Differential gene expression profiles were observed in response to Hras in either wild-type or Ppar-beta null primary keratinocytes and differentail gene edxpression profiles by GW0742 were only found in wild-type keratinocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE32498
ID:
200032498
6.

Genome-wide binding sites of Hypoxia inducible factor 1 (HIF1) and histone modifications

(Submitter supplied) We report the high-throughput profilings of HIF1 and histone modifications in human umbilical vein endothelial cells (HUVEC). By obtaining over two billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of HUVEC under normoxia and hypoxia. We find that HIF1binds to not only to transcriptional starting sites but also enhancer regions and that HIF1 binding sites were overlapped with lysine 4 trimethylatio, monomethylation and lysine 27 acetylation . more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
8 Samples
Download data: BED, WIG
Series
Accession:
GSE39089
ID:
200039089
7.

HIF1 is a master regulator of the adaptive gene expression to hypoxia.

(Submitter supplied) Total 23 samples were derived from [1] HUVEC treated in the absence (0h) or presence of hypoxia (1, 2, 4, 8, 12, and 24 hrs) to determine hypoxia-regulated gene in endothelial cells, [2] control siRNA or HIF1α siRNA transfected HUVEC cells treated in the absence or presence of hypoxia, [3] control siRNA or KDM3A siRNA transfected HUVEC cells treated in the absence or presence of hypoxia, [4] ChIP-seq data for HIF1 binding sites and histone modifications under normoxia and hypoxia in endothelial cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
15 Samples
Download data: CEL
Series
Accession:
GSE35932
ID:
200035932
8.

Transcriptional profiling reveals divergent roles of PPARa and PPARß/d in regulation of gene expression in mouse liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL7440 GPL6246
34 Samples
Download data: CEL
Series
Accession:
GSE17865
ID:
200017865
9.

mRNA profiling reveals divergent roles of PPARa and PPARß/d in regulating mouse liver gene expression (PPARb/d samples)

(Submitter supplied) Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to better elucidate the function of PPARß/d in liver by comparing the effect of PPARa and PPARß/d deletion using whole genome transcriptional profiling and analysis of plasma and liver metabolites. In fed state, the number of genes altered by PPARa and PPARß/d deletion was similar, whereas in fasted state the effect of PPARa deletion was much more pronounced, consistent with the pattern of gene expression of PPARa and PPARß/d. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE17864
ID:
200017864
10.

comprehensive chromatin interaction in TNF alpha stimulated HUVECs

(Submitter supplied) HUVECs were stimulated and samples were prepared after 0 and 30 min. Chromatin interaction mediated by active RNA polymerase II was detected by ChIA-PET.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL10999
4 Samples
Download data: TSV
11.

Expression data of statin treated HUVEC cells transfected siRNA KLF2 or KLF4.

(Submitter supplied) KLF2 and KLF4 are important transcriptional factors in endothelial cells, however their roles in statin treatment has not been elucidated. Here we report the comprehensive change of transcripts of statin treated HUVECs transfected with siRNA KLF2 or KLF4. We used repeated microarray analysis of HUVECs treated with pitavastatin for 4hours. Before statin treatment, cells were transfected with siRNA KLF2 or KLF4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE32693
ID:
200032693
12.

Genome-wide maps of MEF2C and H3K27ac localization in HUVECs

(Submitter supplied) MEF2C is one of the substantially expressed transcriptional factors in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for MEF2C, and performed ChIP-seq to identify MEF2C binding site in whole genome manner. H3K27Ac binding sites were also detected in the same way.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
3 Samples
Download data: BED, WIG
Series
Accession:
GSE32644
ID:
200032644
13.

Expression data of HUVEC cells after statin treatment

(Submitter supplied) 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins, are known to exert endothelial athero-protective effects through the induction of specific transcriptional factors and their downstream target genes besides lowering LDL-cholesterol. However its critical mechanism has not still been elucidated. Here we report the comprehensive change of transcripts induced by pitavastatin. We used repeated microarray analysis of HUVECs treated with pitavastatin for 4-hours, we identified a group of consistently up - or down - regulated genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
18 Samples
Download data: CEL
Series
Accession:
GSE32547
ID:
200032547
14.

mRNA profiling reveals divergent roles of PPARa and PPARß/d in regulating mouse liver gene expression (PPARa samples)

(Submitter supplied) Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to better elucidate the function of PPARß/d in liver by comparing the effect of PPARa and PPARß/d deletion using whole genome transcriptional profiling and analysis of plasma and liver metabolites. In fed state, the number of genes altered by PPARa and PPARß/d deletion was similar, whereas in fasted state the effect of PPARa deletion was much more pronounced, consistent with the pattern of gene expression of PPARa and PPARß/d. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7440
18 Samples
Download data: CEL
Series
Accession:
GSE17863
ID:
200017863
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