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Links from GEO DataSets

Items: 14

1.
Full record GDS5638

Epithelial stem cells derived from induced pluripotent stem cells

Analysis of induced pluripotent stem cell-derived epithelial stem cells (hiPSC-EpSCs). The hiPSCs, which were derived from adult dermal fibroblasts, and hEpSCs directly isolated from hair follicles also examined. Results provide insight into molecular similarities between hiPSC-EpSCs and hEpSCs.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 cell type, 2 tissue sets
Platform:
GPL10558
Series:
GSE51028
7 Samples
Download data
2.

Gene expression profiles among hiPSCs, hiPSC-EpSCs and hEpSCs

(Submitter supplied) Phenotypically comparing the hiPSC-EpSCs with hiPSCs and hEpSCs.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5638
Platform:
GPL10558
7 Samples
Download data: TXT
Series
Accession:
GSE51028
ID:
200051028
3.

Bald scalp retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells

(Submitter supplied) Androgenetic alopecia (AGA) or common baldness results from a marked decrease in hair follicle size. This miniaturization may be related to loss of hair follicle stem or progenitor cells. To test this hypothesis, we analyzed bald and non-bald scalp from the same individuals for the presence of hair follicle stem and progenitor cells using flow cytometry to quantitate cells expressing CYTOKERATIN 15 (KRT15), CD200, CD34 and ALPHA-6-INTEGRIN (ITGA6). more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL570 GPL1261
18 Samples
Download data: CEL, CHP, XLS
Series
Accession:
GSE21569
ID:
200021569
4.

Mouse bulge (CD34+CD200+CD49+) versus secondary hair germ (CD34-CD200+CD49+) versus interfollicular epidermis (CD34-CD200-CD49+)

(Submitter supplied) Mouse back skin was disassociated to single cells, sorted by cell surface markers and tested by microarrray To compare the gene expression of mouse bulge (CD34+CD200+CD49+) versus secondary hair germ (CD34-CD200+CD49+) versus interfollicular epidermis (CD34-CD200-CD49+) xx Bald scalp retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells Androgenetic alopecia (AGA) or common baldness results from a marked decrease in hair follicle size. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE21568
ID:
200021568
5.

Human CD200+CD49+ hair follicle keratinocytes versus CD200-CD49+ keratinocytes

(Submitter supplied) Human hair follicles from normal areas of the scalp were disassociated to single cells, sorted and tested by microarrray To compare the expression of human CD200+ CD49+ hair follicle keratinocytes versus CD200-CD49+ keratinocytes
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE21567
ID:
200021567
6.

Characterization and isolation of stem cell enriched human hair follicle bulge cells

(Submitter supplied) The human hair follicle bulge is an important niche for keratinocyte stem cells (KSC). Elucidation of human bulge cell biology could be facilitated by analysis of global gene expression profiles and identification of unique cell surface markers. The lack of distinctive bulge morphology in human hair follicles has hampered studies of bulge cells and KSC. In this study, we determined the distribution of label-retaining cells to carefully define the human anagen bulge. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1672
Platform:
GPL96
16 Samples
Download data: CEL
Series
Accession:
GSE3419
ID:
200003419
7.
Full record GDS1672

Keratinocyte stem cell–enriched hair follicle bulge cells

Comparison of outer root sheath (ORS) cells of the hair follicle bulge with other defined ORS cell subpopulations within the follicle. Results provide insight into the biological distinctiveness of hair follicle bulge cells, suggesting the bulge is a repository for keratinocyte stem cells (KSCs).
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 cell type, 2 tissue sets
Platform:
GPL96
Series:
GSE3419
16 Samples
Download data: CEL
8.

Lgr6 Marks Stem Cells in the Hair Follicle that Generate all Cell Lineages of the Skin

(Submitter supplied) Mammalian epidermis consists of three self-renewing compartments: the hair follicle, sebaceous gland and interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative to the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair follicles, Lgr6+ cells resided in a previously uncharacterized region directly above the follicle bulge. They expressed none of the known bulge stem cell markers. Prenatal Lgr6+ cells established the hair follicle, sebaceous gland and interfollicular epidermis. Postnatally, Lgr6+ cells generated sebaceous gland and interfollicular epidermis, while contribution to hair lineages gradually diminished with age. Adult Lgr6+ cells executed long-term wound repair, including the formation of new hair follicles. We conclude that Lgr6 marks the most primitive epidermal stem cell.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
2 Samples
Download data: TXT
Series
Accession:
GSE20269
ID:
200020269
9.

Gene expression profile of human melanocytes derived from iPS cells

(Submitter supplied) This experiment was designed to show the similarity among normal human epidermal melanocytes, melanocytes derived from human 3F-induced pluripotent stem (iPS) cells, and human 3F-iPS cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
3 Samples
Download data: TXT
Series
Accession:
GSE23805
ID:
200023805
10.

Epithelial stem cells co-cultured with the dermal papilla

(Submitter supplied) Clonogenic keratinocyte stem cells isolated from the bulge area of human telogen follicles were co-cultured with dermal papilla cells in a transwell system. RNA was isolated from stem cells for different periods of time (day 0, 1, 2, and 5) after co-culture with DP and analyzed for changes in gene expression using Genechip microarrays. Keywords = epithelial stem cells Keywords = DP Keywords = co-culture Keywords: other
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS687
Platform:
GPL8300
3 Samples
Download data
Series
Accession:
GSE1470
ID:
200001470
11.
Full record GDS687

Dermal papilla-induced epithelial stem cell differentiation

Analysis of dermal papilla (DP) induced epithelial stem cell differentiation. Keratinocyte stem cells from bulge area of telogen hair follicle co-cultured with DP over a 5 day period.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 time sets
Platform:
GPL8300
Series:
GSE1470
3 Samples
Download data
DataSet
Accession:
GDS687
ID:
687
12.

Genomic Analysis Reveals Distinct Mechanisms and Functional Classes of SOX10-Regulated Genes in Melanocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9250 GPL16570 GPL17021
14 Samples
Download data: CEL, TXT, WIG
Series
Accession:
GSE69950
ID:
200069950
13.

Genomic Analysis Reveals Distinct Mechanisms and Functional Classes of SOX10-Regulated Genes in Melanocytes [ChIP-Seq]

(Submitter supplied) We performed ChIP-Seq analysis of SOX10, histone H3 lysine 27 acetylation (H3K27ac) and H3K27 trimethylation (H3K27me3) in melanocytes to profile the genomic binding sites of SOX10 and the chromatin landscape. In parallel, we generated Sox10 haploinsufficient cell lines using gene knockout approaches and conducted microarray gene expression analysis to identify functional gene targets of SOX10 transcriptional regulation in melanocytes. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL9250
8 Samples
Download data: TXT, WIG
Series
Accession:
GSE69949
ID:
200069949
14.

Genomic Analysis Reveals Distinct Mechanisms and Functional Classes of SOX10-Regulated Genes in Melanocytes [gene expression]

(Submitter supplied) We performed ChIP-Seq analysis of SOX10, histone H3 lysine 27 acetylation (H3K27ac) and H3K27 trimethylation (H3K27me3) in melanocytes to profile the genomic binding sites of SOX10 and the chromatin landscape. In parallel, we generated Sox10 haploinsufficient cell lines using gene knockout approaches and conducted microarray gene expression analysis to identify functional gene targets of SOX10 transcriptional regulation in melanocytes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
6 Samples
Download data: CEL
Series
Accession:
GSE69860
ID:
200069860
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