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Links from GEO DataSets

Items: 17

1.
Full record GDS5642

Tendon development: embryonic limb tendon cells

Analysis of tendon cells isolated by FACS from forelimbs of embryonic day 11.5, E12.5 and E14.5 scleraxis (Scx)-GFP embryos. Basic helix-loop-helix transcription factor Scx is a specific tendon and ligament marker. Results provide insight into molecular pathways involved in tendon development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 age sets
Platform:
GPL1261
Series:
GSE54207
9 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS5642
ID:
5642
2.

Expression data from mouse limb tendon cells during development.

(Submitter supplied) We have undertaken a screen of mouse limb tendon cells in order to identify molecular pathways involved in tendon development. Mouse limb tendon cells were isolated based on Scleraxis (Scx) expression at different stages of development: E11.5, E12.5 and E14.5 Microarray comparisons were carried out between tendon progenitor and differentiated stages.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5642
Platform:
GPL1261
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE54207
ID:
200054207
3.

limb tendon RNAseq

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
5 Samples
Download data: TXT
Series
Accession:
GSE65180
ID:
200065180
4.

RNAseq comparison of gene expression profiles in ScxGFP positive cells from E11.5, E13.5 and E15.5 hindlimb samples

(Submitter supplied) RNAs were isolated from FACS sorted ScxGFP positive cells of hindlimbs at E11.5, E13.5 and E15.5, and characterized by RNAseq
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
3 Samples
Download data: TXT
Series
Accession:
GSE65179
ID:
200065179
5.

RNAseq comparison of gene expression profiles in ScxGFP positive cells and ScxGFP negative cells from E13.5 forelimb samples

(Submitter supplied) RNAs were isolated from FACS sorted ScxGFP positive cells and GFP negative cells of forelimbs at E13.5, and characterized by RNAseq
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: TXT
Series
Accession:
GSE65177
ID:
200065177
6.

Enhanced differentiation of hESCs into multipotential mesodermal stem cells by inhibition of TGF-b signaling by using SB

(Submitter supplied) Directing differentiation of human embryonic stem cells (hESC) into specific cell types using an easy and reproducible protocol is a perquisite for the clinical use of hESC in regenerative medicine protocols. Here, we report the generation of mesodermal cells with differentiation potential to myocytes, osteoblasts, chondrocytes and adipocytes. We demonstrate that during hESC differentiation as embryoid bodies (EB), inhibition of TGF-b/Activin/Nodal signaling using SB-431542 (SB) markedly up-regulated paraxial mesodermal markers (TBX6, TBX5), early myogenic transcriptional factors (Myf5, Pax7) as well as myocyte committed markers (NCAM, CD34, Desmin, MHC (fast), alpha-smooth muscle actin, Nkx2.5, cTNT). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE15553
ID:
200015553
7.

Gene expression profiling in murine Smad-deficient CD4+ T cells stimulated with TGF-b

(Submitter supplied) TGF-b is an important pleiotropic cytokine with potent immunoregulatory properties. Although many previous reports have been proposed for the immunoregulatory functions of TGF-b on T cells, such as the suppression of cell proliferation, cytokine production and cytokine signaling, as well as the induction of apoptosis, it is not well elucidated whether the each effect of TGF-b on T cells is dependent on Smad signaling or Smad-independent other signaling pathways. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE19601
ID:
200019601
8.

Profiling of genes regulated by TGF-beta in lung carcinoma (A549) and immortalized lung epithelial (HPL1D)cells.

(Submitter supplied) TGF-beta is one of the key cytokines implicated in various disease processes including cancer. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells and in contrast, acts as a pro-tumour cytokine by promoting tumour angiogenesis, immune-escape and metastasis. It is not clear if various actions of TGF-beta on normal and tumour cells are due to differential gene regulations. Hence we studied the regulation of gene expression by TGF-beta in normal and cancer cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2932
Platform:
GPL3515
12 Samples
Download data
Series
Accession:
GSE7436
ID:
200007436
9.
Full record GDS2932

TGF-beta effect on normal and tumor cell lines: time course

Analysis of normal lung epithelial HPL1D cells and lung adenocarcinoma A549 cells treated with TGF-beta for up to 12 hours. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells but acts as a pro-tumor cytokine by promoting tumour angiogenesis, immune-escape, and metastasis.
Organism:
Homo sapiens
Type:
Expression profiling by array, log2 ratio, 2 cell line, 3 time sets
Platform:
GPL3515
Series:
GSE7436
12 Samples
Download data
10.

Differentially expressed transcriptomes of P7 mouse tendon cells with targeted deletion of TGF-beta signaling

(Submitter supplied) Background: Our group has previously shown that disruption of TGFβ signaling in mouse limb mesenchyme resulted in arrested tendon formation (Pryce et at, 2007). To examine the role of TGFβ signaling in later stages of tendon development, the TGF-beta type II receptor gene (Tgfbr2) was targeted in the Scleraxis (Scx)-expressing cell lineage using the Cre-lox recombination system. We find that tendon development was not disrupted in mutant (Tgfbr2;ScxCre) embryos. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE139558
ID:
200139558
11.

Transcriptional analysis of tendons and tenocytes from mice with a targeted deletion of scleraxis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
27 Samples
Download data
Series
Accession:
GSE145864
ID:
200145864
12.

Transcriptional analysis of tenocytes from mice with a targeted deletion of scleraxis

(Submitter supplied) We report RNA sequencing data from tenocytes cultured from the tail tendons of adult male mice in the C57Bl/6 background that either have the scleraxis gene (Scx+) or mice in which scleraxis has been deleted using CreERT2 driven from the Rosa26 locus using 4-hydroxytamoxifen (4HT).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data: TXT
Series
Accession:
GSE145863
ID:
200145863
13.

Transcriptional analysis of tendons from mice with a targeted deletion of scleraxis

(Submitter supplied) We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 background that either have the scleraxis gene (Scx+) or mice in which scleraxis has been deleted using CreERT2 driven from the Rosa26 locus (Scx-). Mice in which scleraxis was deleted were created by crossing scleraxis-floxed mice with Rosa26-CreERT2 mice. Rosa26-CreERT2 mice that did not have a floxed scleraxis allele served as controls. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
19 Samples
Download data: TXT
Series
Accession:
GSE139493
ID:
200139493
14.

The transcription factor Scleraxis differentially regulates gene expression in tenocytes isolated at different developmental stages

(Submitter supplied) Purpose:- RNA sequencing was performed on adult and fetal equine tenocytes expressing a specific short hairpin RNA against scleraxis (shSCX) versus a non-target (NT) scrambled control Methods:- mRNA profiles of four independent biological lines of adult and fetal NT and shSCX expressing tenocytes were generated by RNA sequencing, using Illumina NovaSeq6000. The sequence reads that passed quality filters were analyzed using the pseudoaligner Salmon and differential expression quantified using DESeq2. more...
Organism:
Equus caballus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26749
16 Samples
Download data: CSV
Series
Accession:
GSE149570
ID:
200149570
15.

RNA-seq analysis of Scx-lineage cell depletion to investigate tendon cell functions during flexor tendon healing

(Submitter supplied) Little is understood about the roles of tendon cells during flexor tendon healing. To better understand tendon cell functions, the Scx-Cre mouse was crossed to the DTR mouse model to facilitate scleraxis lineage cell depletion prior to acute flexor tendon injury and repair. WT (cre-) and experimental (cre+) mice underwent complete transection and repair of the flexor digitorum longus tendon. Repaired tendons were harvested at 14 and 28 days post-repair for bulk RNA-Seq analysis to examine possible mechanisms driving differential healing due to Scx lineage cell depletion.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: XLSX
Series
Accession:
GSE156157
ID:
200156157
16.

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

(Submitter supplied) The connection between different tissues is vital for the development and function of all organs and systems. In the musculoskeletal system, the attachment of elastic tendons to stiff bones poses a mechanical challenge that is solved by the formation of a transitional tissue, which allows the transfer of muscle forces to the skeleton without tearing. Here, we show that tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte transcriptomes, which is regulated by sharing regulatory elements with these cells and by Krüppel-like factors transcription factors (KLF). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
1 Sample
Download data: MTX, TSV, XLSX
Series
Accession:
GSE160090
ID:
200160090
17.

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

(Submitter supplied) "The connection between different tissues is vital for the development and function of all organs and systems. In the musculoskeletal system, the attachment of elastic tendons to stiff bones poses a mechanical challenge that is solved by the formation of a transitional tissue, which allows the transfer of muscle forces to the skeleton without tearing. Here, we show that tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte transcriptomes, which is regulated by sharing regulatory elements with these cells and by Krüppel-like factors transcription factors (KLF). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL19057
20 Samples
Download data: TXT
Series
Accession:
GSE144306
ID:
200144306
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