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Links from GEO DataSets

Items: 20

1.
Full record GDS5644

Transforming growth factor, beta receptor II knockout effect on embryonic posterior palate

Analysis of posterior portions of the palate from E15.5 embryos with an epithelial cell-specific conditional inactivation of Transforming growth factor, beta receptor II (Tgfbr2). Results, together with those from GDS4921, provide insight into the role of TGFβ signaling in soft palate development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE46211
12 Samples
Download data: CEL
2.

Gene expression profiling of anterior and posterior palatal tissue from Tgfbr2 mutant mouse models

(Submitter supplied) The overall goal of this project is to investigate the role of TGF-beta signaling in epithelial cells as it pertains to the orientation of muscle fibers in the soft palate during embryogenesis. Here, we first conducted gene expression profiling of the anterior and posterior portions of the palate from wild-type mice. In addition, we also conducted gene expression profiling of the posterior palate in mutant mice with an epithelium-specific conditional inactivation of the Tgfbr2 gene. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4921 GDS5644
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE46211
ID:
200046211
3.
Full record GDS4921

Embryonic anterior and posterior palate

Analysis of anterior and posterior portions of the palate from wild-type animals at embryonic day 15.5. Results, together with those from GDS5644, provide insight into the role of Transforming growth factor, beta (TGFβ) signaling across the soft palate during development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 tissue sets
Platform:
GPL1261
Series:
GSE46211
12 Samples
Download data: CEL
4.

Gene expression profiling of Tgfbr2 mutant mouse models of cleft palate

(Submitter supplied) The overall goal of this project is to investigate the role of TGF-beta signaling in palate development in order to discover candidate therapeutics for preventing and treating congenital birth defects. Here, we conducted gene expression profiling of embryonic palatal tissue from wild type mice as well as those with a neural crest specific conditional inactivation of the Tgfbr2 gene. The latter mice provide a model of cleft palate formation.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4483
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE22989
ID:
200022989
5.
Full record GDS4483

TGF-beta receptor type II knockdown effect on embryonic palatal tissue

Analysis of palatal tissues from E14.5 animals depleted for f TGF-beta receptor type II in cranial neural crest cells. Palatal fusion takes place at E14.5. Results provide insight into the role of TGF-beta signaling in palate development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE22989
10 Samples
Download data: CEL
6.

Gene expression profiling of primary mouse embryonic palatal mesenchymal cells in Tgfbr2 mutant mouse models

(Submitter supplied) The overall goal of this project is to investigate the role of TGF-beta signaling in regulating the cellular metabolism of cranial neural crest (CNC) cells during palate development. Here, we conducted gene expression profiling of primary mouse embryonic palatal mesenchymal (MEPM) cells from wild type mice as well as those with a neural crest specific conditional inactivation of the Tgfbr2 gene. The latter mice provide a model of cleft palate, which is among the most common congenital birth defects and observed in many syndromic conditions.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5008
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE46150
ID:
200046150
7.
Full record GDS5008

Transforming growth factor beta deficiency effect on embryonic palatal mesenchymal cells

Analysis of embryonic palatal mesenchyme (PM) cells from mice with a deletion of Tgfbr2 in cranial neural crest cells. These Tgfbr2fl/fl;Wnt1-Cre mice develop cleft palate as the result of abnormal TGFβ signaling activation. Results provide insight into the role of TGFβ in palatogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE46150
8 Samples
Download data: CEL
8.

Gene expression profiling of the tongue in Tgfbr2 mutant mouse models

(Submitter supplied) The overall goal of this project is to investigate the role of TGF-beta signaling in tongue development in order to study the contribution of cranial neural crest (CNC) cells towards the patterning of cranial mesoderm for proper tongue formation. Here, we conducted gene expression profiling of embryonic tongue tissue from wild type mice as well as those with a neural crest specific conditional inactivation of the Tgfbr2 gene. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE45968
ID:
200045968
9.

Hepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice

(Submitter supplied) Gene expression of hepatocyt-specific knockout of Pten and of Pten and Tgfbr2 in mice as a model for human cholangiocarcinoma was determined Affymetrix Mouse 1.0ST chips were used to measure gene expression
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
11 Samples
Download data: CEL
Series
Accession:
GSE66717
ID:
200066717
10.

Next-generation RNA Sequencing and Transcriptome Comparison of Mouse Wild Type and Mesenchymal Tgfbr2 conditional knockout lungs of E15.5

(Submitter supplied) Lung mesenchymal knockout of transforming growth factor, beta receptor II (Tgfbr2) will lead to lung malformation, including impaired lung branching and cystic lesion. In order to understand the underlying mechanisms, total RNA of wild type and mesenchymal Tgfbr2 knockout lungs were isolated and sequenced using the next-generation RNA sequencing technique.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: XLS, XLSX
Series
Accession:
GSE98138
ID:
200098138
11.

Next-Generation Sequencing Facilitates Quantitative Analysis of the Effects of Wnt Agonist Treatments on Palate Formation

(Submitter supplied) Nonsyndromic clefts of the palate and/or lip are common birth defects arising in about 1/700 live births worldwide. They are caused by multiple genetic and environmental factors, can only be corrected surgically and require complex post-operative care that imposes significant burdens on individuals and society. Our understanding of the molecular networks that control palatogenesis has advanced through studies on mouse genetic models of cleft palate. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: XLSX
Series
Accession:
GSE101825
ID:
200101825
12.

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and Pax9-/- Palate shelves Transcriptomes

(Submitter supplied) Nonsyndromic clefts of the palate and/or lip are common birth defects arising in about 1/700 live births worldwide. They are caused by multiple genetic and environmental factors, can only be corrected surgically and require complex post-operative care that imposes significant burdens on individuals and society. Our understanding of the molecular networks that control palatogenesis has advanced through studies on mouse genetic models of cleft palate. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: XLSX
Series
Accession:
GSE89603
ID:
200089603
13.

Regulation of the epithelial adhesion molecule CEACAM1 is essential for palate formation.

(Submitter supplied) Cleft palate results from a mixture of genetic and environmental factors and occurs when the bilateral palatal shelves fail to fuse. The objective of this study was to search for new genes involved in mouse palate formation. Gene expression of murine embryonic palatal tissue was analyzed at the various developmental stages before, during, and after palate fusion using GeneChip? microarrays. Ceacam1 was one of the highly up-regulated genes during and after fusion in palate formation, and this was confirmed by quantitative real-time PCR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL
Series
Accession:
GSE43651
ID:
200043651
14.

Gene expression profiles in CDX2P-G19Cre;Apcflox/flox;Tgfbr2flox/flox and CDX2P-G19Cre;Apcflox/flox mouse tumors

(Submitter supplied) Mutations in TGFBR2, a component of the transforming growth factor (TGF)-β signaling pathway, occur in high-frequency microsatellite instability (MSI-H) colorectal cancer (CRC). In mouse models, Tgfbr2 inactivation in the intestinal epithelium accelerates the development of malignant intestinal tumors in combination with disruption of the Wnt-β-catenin pathway. However, no studies have further identified the genes influenced by TGFBR2 inactivation following disruption of the Wnt-β-catenin pathway. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE82133
ID:
200082133
15.

Gene expression profiling of the palate in Erk2 mutant mouse models

(Submitter supplied) The overall goal of this project is to investigate the role of Erk2-mediated signaling in regulating the cellular metabolism of cranial neural crest (CNC) cells during palate development. Here, we conducted gene expression profiling of palate tissue from wild type mice as well as those with a neural crest specific conditional inactivation of the Erk2 gene. The latter mice exhibit micrognathia, tongue defects and cleft palate, which is among the most common congenital birth defects and observed in many syndromic conditions.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE67087
ID:
200067087
16.

Expression profiling in palatal mesenchymal cells stimulated with TGF-beta2 in the presence and absence of TGFbRI and Tak1 kinase inhibitors

(Submitter supplied) TGF-beta signaling in neural crest cells is required for normal craniofacial development. This signaling can be transduced via TGF-beta type I receptors (TGFbRI) using Smad-dependent or Smad independent signaling pathways. We used microarrays to identify TGF-beta-responsive genes that are dependent either on TGFbRI kinase, Tak1 kinase or both.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4619
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE45491
ID:
200045491
17.
Full record GDS4619

Palatal mesenchymal cells response to TGFβ2 stimulation in the presence of Tak1 kinase and TGFβRI inhibitors

Analysis of palatal mesenchymal cells treated with TGFβ-activated kinase 1 (Tak1) inhibitor or TGFβ type I receptor (TGFβRI) kinase inhibitor for 1hr and then stimulated with TGF-β2 for 2 hrs. Results provide insight into TGFβ signaling mechanisms involved in craniofacial development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 protocol sets
Platform:
GPL1261
Series:
GSE45491
4 Samples
Download data: CEL, CHP
18.

Cascade regulation of sweat gland development by Wnt, Eda and Shh pathways

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6867
20 Samples
Download data: TXT
Series
Accession:
GSE50863
ID:
200050863
19.

Cascade regulation of sweat gland development by Wnt, Eda and Shh pathways [Dkk4 transgenic]

(Submitter supplied) Millions of sweat glands required to maintain body temperature develop from embryonic ectoderm by a poorly defined mechanism. We present evidence for temporal cascade regulation of sweat gland development by Wnt, Eda and Shh pathways. The first stage, sweat gland induction, failed completely when Wnt/β-catenin signaling was blocked in skin epithelium, accompanied by sharp downregulation of Wnt, Eda and Shh pathway genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6867
8 Samples
Download data: TXT
Series
Accession:
GSE50862
ID:
200050862
20.

Cascade regulation of sweat gland development by Wnt, Eda and Shh pathways [beta-catenin knockout]

(Submitter supplied) Millions of sweat glands required to maintain body temperature develop from embryonic ectoderm by a poorly defined mechanism. We present evidence for temporal cascade regulation of sweat gland development by Wnt, Eda and Shh pathways. The first stage, sweat gland induction, failed completely when Wnt/β-catenin signaling was blocked in skin epithelium, accompanied by sharp downregulation of Wnt, Eda and Shh pathway genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6867
12 Samples
Download data: TXT
Series
Accession:
GSE50859
ID:
200050859
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