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Links from GEO DataSets

Items: 18

1.
Full record GDS5646

Early Parkinson's disease: peripheral blood

Analysis of peripheral blood of untreated patients with stage 1 Parkinson's disease (PD), according to the Hoehn-Yahr scale, and paired healthy, age- and sex-matched controls. Results provide insight into molecular mechanisms underlying the initiation of the development of PD.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 10 individual sets
Platform:
GPL10558
Series:
GSE54536
10 Samples
Download data
2.

Involvement of endocytosis and alternative splicing in the formation of the pathological process in Parkinson's Disease

(Submitter supplied) We performed a whole-transcriptome analysis of the peripheral blood of untreated patients with stage 1 PD (Hoehn–Yahr scale).
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5646
Platform:
GPL10558
10 Samples
Download data: TXT
Series
Accession:
GSE54536
ID:
200054536
3.

Transcriptomic profiling of peripheral blood mononuclear cells from patients with Parkinson's disease and control subjects

(Submitter supplied) To get insight into systemic molecular events associated with Parkinson's disease (PD), an age-related neurodegenerative disorder, we compared gene expression patterns of peripheral blood mononuclear cells (PBMC) derived from elderly healhy controls and from PD patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
50 Samples
Download data: TXT
Series
Accession:
GSE49126
ID:
200049126
4.

Gene Expression in the Blood of Parkinson's Disease Patients

(Submitter supplied) Peripheral blood was collected from 18 Parkinson's Disease (PD) patients and 12 healthy controls (Ctrls). Total RNA was isolated and hybridized onto Affymetrix Exon_ST1 arrays to find in PDs versus controls: 1) genes that are differentiallly expressed and 2) genes with differential exonic expression (alternative splicing).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
28 Samples
Download data: CEL, TXT
Series
Accession:
GSE18838
ID:
200018838
5.

Brain transcriptomic profiling in idiopathic and LRRK2-associated Parkinson's disease

(Submitter supplied) LRRK2 mutations are the most common genetic cause of Parkinson’s disease (PD). We performed a whole-genome RNA profiling of locus coeruleus post-mortem tissue from idiopathic PD (IPD) and LRRK2-associated PD patients. The differentially expressed genes found in IPD and LRRK2-associated PD were involved in the gene ontology terms of synaptic transmission and neuron projection. In addition, in the IPD group we found associated genes belonging to the immune system. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
10 Samples
Download data: CEL
Series
Accession:
GSE34516
ID:
200034516
6.

Whole-transcriptome high-throughput RNA sequencing of blood leukocytes from Parkinson's disease human patients pre- and post-deep brain stimulation

(Submitter supplied) The given data set is the first deep sequencing transcriptome-wide data set of human Parkinson's disease (PD) patients RNA. The data set was produced from blood leukocytes of PD patients, from the same patients following deep brain stimulation (DBS), and from matched healthy control volunteers. Post-DBS samples were taken from the patients while being on electrical stimulation (ON-Stim), and following one hour off of electrical stimulation (OFF-Stim state). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9442
13 Samples
Download data: BED, GFF3, TAB, TXT
Series
Accession:
GSE42608
ID:
200042608
7.

Expression data from human patients with slow or rapid Parkinson's Disease progression

(Submitter supplied) Parkinson’s Disease is a multi-system, disabling progressive neurodegenerative condition. Clinical progression is highly heterogeneous and, thus far, there are not available biomarkers to accurately predict the rate of disease progression. Thus, identifying molecular signatures that allow discriminating between different progression rates might significantly assist the therapeutic strategy, and enable improved outcomes in clinical trials. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
67 Samples
Download data: CEL
Series
Accession:
GSE80599
ID:
200080599
8.

Expression data from advanced Parkinson's disease (PD) patients leukocytes - prior to and following deep brain stimulation (DBS) treatment in on and off stimulation conditions, and matched healthy control (HC) subjects

(Submitter supplied) Sub-thalamic deep brain stimulation (DBS) reversibly modulates Parkinson’s disease (PD) motor symptoms, providing an unusual opportunity to compare leukocyte transcripts in the same subjects before and after neurosurgery and after disconnecting the stimulus (ON-and OFF-stimulus). Here, we report rapid stimulus-induced and largely reversible changes in PD leukocyte transcripts, which were larger in scope than the disease-induced changes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5188
27 Samples
Download data: CEL
Series
Accession:
GSE23676
ID:
200023676
9.

Expression data from naïve and MPTP-exposed cholinergic transgenic mice

(Submitter supplied) PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the first drugs used for symptomatic treatment of PD. Of note, MPTP intoxication is a model of choice for symptomatic neuroprotective therapies since it have been quite predictive. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4157
Platform:
GPL8321
29 Samples
Download data: CEL
Series
Accession:
GSE31458
ID:
200031458
10.
Full record GDS4157

Dopaminergic neurotoxin MPTP-based Parkinson's disease risk model: brain regions

Analysis of caudate-putamen and pre-frontal cortex from transgenics, over-expressing either risk-associated synaptic acetylcholinesterase (AChE)-S variant or the protective soluble AChE-R variant, exposed to environmental risk factor MPTP. Results provide insights into the molecular basis of PD.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 3 genotype/variation, 2 tissue sets
Platform:
GPL8321
Series:
GSE31458
29 Samples
Download data: CEL
DataSet
Accession:
GDS4157
ID:
4157
11.

Association between alpha-synuclein blood transcripts and early Parkinson's disease

(Submitter supplied) Importance. Biological markers of Parkinson’s disease are essential for achieving disease modification. Objective. To determine the association of SNCA blood transcript levels with prevalence of Parkinson’s disease. Background. The SNCA locus is preferentially transcribed in neurons and blood cells. Non-coding genetic variants and neuronal aggregates of α-synuclein protein associate this locus with sporadic Parkinson’s disease and suggest a potential role for abnormal SNCA transcription in the disease mechanism. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
142 Samples
Download data: TXT
Series
Accession:
GSE57475
ID:
200057475
12.

Blood transcriptomics of drug-naïve sporadic Parkinson’s disease patients

(Submitter supplied) Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provide new information on the diagnosis and pathogenesis of sporadic PD. We study changes in gene expression in the blood of 40 sporadic PD patients and 20 healthy controls (“Discovery set”) by taking advantage of the Affymetrix platform. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
59 Samples
Download data: CEL
Series
Accession:
GSE72267
ID:
200072267
13.

Transcriptional analysis of multiple brain regions in Parkinson's disease

(Submitter supplied) Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
93 Samples
Download data: CEL, CHP
Series
Accession:
GSE20295
ID:
200020295
14.

Transcriptional analysis of whole substantia nigra in Parkinson's disease

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
29 Samples
Download data: CEL, CHP
Series
Accession:
GSE20292
ID:
200020292
15.

Transcriptional analysis of putamen in Parkinson's disease

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
35 Samples
Download data: CEL, CHP
Series
Accession:
GSE20291
ID:
200020291
16.

Transcriptional analysis of prefrontal area 9 in Parkinson's disease

(Submitter supplied) Post mortem tissue was dissected from two groups of age and gender matched groups of Parkinson and Control subjects
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
29 Samples
Download data: CEL, CHP
Series
Accession:
GSE20168
ID:
200020168
17.

microRNA (miRNA) expression profiling of PBMCs of Parkinson's disease (PD) patients and controls

(Submitter supplied) To investigate the role of miRNAs in the etiology of idiopathic PD, we conducted global miRNA expression profiling in peripheral blood mononuclear cells (PBMCs) of PD patients and controls.
Organism:
Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Homo sapiens; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
32 Samples
Download data: TXT
Series
Accession:
GSE16658
ID:
200016658
18.

Skeletal Muscle Transcriptional Networks Linked to Motor Unit Remodeling in Human Parkinson’s Disease

(Submitter supplied) We performed transcriptional profiling to test the hypothesis that type I grouping severity in Parksino's disease link to distinct gene expression networks
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
36 Samples
Download data: TXT
Series
Accession:
GSE128177
ID:
200128177
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