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Links from GEO DataSets

Items: 18

1.
Full record GDS5656

Forkhead box O 1,3,4 muscle-specific knockout effect on fasted gastrocnemius muscle

Analysis of gastrocnemius muscle from starved males with muscle-specific deletion of Forkhead Box O transcription factors 1, 3 and 4 (FoxO1,3,4-/-). Results provide insight into the collective roles of FoxOs during muscle atrophy.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 stress sets
Platform:
GPL1261
Series:
GSE52667
4 Samples
Download data: CEL
2.

The FoxO signature in protein breakdown

(Submitter supplied) Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver gluconeogenesis and tissues protein synthesis. Proteolysis in muscle is orchestrated by a set of genes named atrophy-related genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5656
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE52667
ID:
200052667
3.

FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy

(Submitter supplied) Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed by insulin and thus are key mediators of insulin action. To study their role in diabetic muscle wasting, we created mice with muscle-specific triple knockout of FoxO1/3/4 and induced diabetes in these M-FoxO-TKO mice with streptozotocin (STZ). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
21 Samples
Download data: CSV
Series
Accession:
GSE136948
ID:
200136948
4.

Sestrin prevents skeletal muscle atrophy

(Submitter supplied) We identify sestrins, a family of stress-inducible metabolic regulators, as protective factors against muscle wasting. Sestrin expression decreases during inactivity and its genetic deficiency exacerbates muscle wasting; conversely, sestrin overexpression suffices to prevent atrophy.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
42 Samples
Download data: TXT
Series
Accession:
GSE136866
ID:
200136866
5.

Identification of FoxO target genes during C-26 cancer cachexia

(Submitter supplied) Forkhead BoxO (FoxO) transcription factors expressed in adult skeletal muscle promote muscle atrophy during various catabolic conditions. We have identified the genome wide target genes and biological networks regulated by FoxO in skeletal muscle during Colon-26 (C-26) cancer cachexia. In this dataset, we include the expression data obtained from the tibialis anterior muscles of control and severely cachectic Colon-26 mice in which FoxO-dependent transcription was either intact (AAV9-EV) or inhibited (AAV9-d.n.FoxO). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18535
16 Samples
Download data: CEL
Series
Accession:
GSE56555
ID:
200056555
6.

Regulation of Glucose Uptake and Inflammation by FOXO1 and FOXO3 in Skeletal Muscle

(Submitter supplied) Forkhead box class O (FoxO) transcription factors regulate whole body energy metabolism, skeletal muscle mass and substrate switching. To elucidate the role of FOXO in skeletal muscle, dominant negative (dn) constructs for FOXO1 (FOXO1dn) or FOXO3 (FOXO3dn) were transfected by electroporation into mouse tibialis anterior muscle and glucose uptake, signal transduction, and glucose stimulated gene expression profiles were assessed. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
24 Samples
Download data: CEL
Series
Accession:
GSE105778
ID:
200105778
7.

burde-affy-arabi-64764

(Submitter supplied) In skeletal muscle, the pattern of electrical activity regulates the expression of proteins involved in synaptic transmission, contraction and metabolism. Disruptions in electrical activity, resulting from prolonged bed-rest, cast-immobilization or trauma, inevitably lead to muscle atrophy. The mechanisms that regulate muscle atrophy are poorly understood, but it seems likely that changes in gene expression play a key role in initiating and maintaining a muscle atrophy program. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
11 Samples
Download data: CEL
Series
Accession:
GSE4411
ID:
200004411
8.

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

(Submitter supplied) Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting genetic analysis of the role of FoxOs in the neoplastic phenotypes linked to PI3K-AKT activation. While germline or somatic deletion of up to five FoxO alleles produced remarkably modest neoplastic phenotypes, broad somatic deletion of all FoxOs engendered a progressive cancer-prone condition characterized by thymic lymphomas and hemangiomas, demonstrating that the mammalian FoxOs are indeed bona fide tumor suppressors. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE27932
ID:
200027932
9.

Effect of endophilin A deficiency in mouse hippocampus

(Submitter supplied) We tested how complete or partial loss of endophilin A1, A2 and A3 affects gene expression in mouse hippocampus. Total loss of endophilin (triple knock-outs, TKO) was assessed in newborn mice, since the TKO mice only survive only several hours after birth. Partial loss of endophilin (endoA1,A2 double knock-out, DKO) was assessed between
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
49 Samples
Download data: XLS, XLSX
Series
Accession:
GSE85702
ID:
200085702
10.

FoxO maintains a genuine quiescent muscle stem-cell state until geriatric age

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL17021
145 Samples
Download data: BW
Series
Accession:
GSE157563
ID:
200157563
11.

FoxO maintains a genuine quiescent muscle stem-cell state until geriatric age (RNA-seq)

(Submitter supplied) We identify two quiescent stem-cell states through relative CD34 expression: CD34High, with stemness properties (genuine state), and CD34Low, more committed to myogenic differentiation (primed state). The genuine-quiescent state is preserved into later life succumbing only in extreme old age due to acquisition of primed-state traits. We identified niche-derived IGF1-dependent Akt activation as detrimental to the genuine stem-cell state by imposing primed-state features via FoxO inhibition. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
119 Samples
Download data: TXT, XLSX
Series
Accession:
GSE157562
ID:
200157562
12.

Expression data from mouse skeletal muscle

(Submitter supplied) Evidence suggests that diabetes mellitus is a promoting factor of sarcopenia; mechanism of how diabetes mellitus accelerates the development of sarcopenia is not known. We have recently established a model of diabetes-induced skeletal muscle mass loss in mice by using streptozotocin. We used microarrays to detail the global programme of gene expression underlying skeletal muscle atrophy in STZ treated mice and identified up-regulated or down-regulated genes during this process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
4 Samples
Download data: CEL
Series
Accession:
GSE123540
ID:
200123540
13.

Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14726
56 Samples
Download data: TXT
Series
Accession:
GSE35705
ID:
200035705
14.

CP003: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy

(Submitter supplied) The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identify novel transcriptional targets of this module we performed an unbiased microarray analysis after conditional activation of the key components PI3K, PKB, FOXO3 and FOXO4. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14726
16 Samples
Download data: TXT
Series
Accession:
GSE35703
ID:
200035703
15.

CP001: Modulation of glutamine metabolism by the PI3K-PKB/c-akt-FOXO network regulates autophagy

(Submitter supplied) The PI3K-PKB/c-akt-FOXO signalling network provides a major intracellular hub for regulation of cell proliferation, survival and stress resistance1. Here we report a novel function for FOXO transcription factors in regulating autophagy through modulation of intracellular glutamine levels. To identify novel transcriptional targets of this module we performed an unbiased microarray analysis after conditional activation of the key components PI3K, PKB, FOXO3 and FOXO4. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14726
40 Samples
Download data: TXT
Series
Accession:
GSE35701
ID:
200035701
16.

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

(Submitter supplied) Sarcopenia is a degenerative condition that consists in the age-induced atrophy and functional decline of skeletal muscle cells (myofibers). A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but such model has not been extensively tested. Here, we find that the levels of the ubiquitin ligase UBR4 increase in skeletal muscle with aging, and that muscle-specific UBR4 loss rescues age-associated myofiber atrophy in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9185
16 Samples
Download data: TXT
Series
Accession:
GSE149637
ID:
200149637
17.

Expression level comparison under dividing and quiescent states in human primary fibroblasts

(Submitter supplied) To identify genes with different expression levels in dividing and quiescent cells, mRNA-sequencing was done in both conditions for human primary fibroblasts (HCA2-hTert).
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE86867
ID:
200086867
18.

FOXO in mouse brain

(Submitter supplied) Gene expression in FOXO KO vs WT brain
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
17 Samples
Download data: CEL, CHP
Series
Accession:
GSE102137
ID:
200102137
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