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Items: 20

1.
Full record GDS5660

Early postnatal skeletal muscle stem cells: time course

Analysis of myogenic stem cells called satellite cells (mSCs) FACS-sorted from the trunk of Pax3GFP/+ mice at postnatal days 1, 12, and 28, a period when most mSCs are in proliferation and quiescence states. Results provide insight into molecular basis of early postnatal skeletal muscle development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 age, 2 tissue sets
Platform:
GPL1261
Series:
GSE65927
11 Samples
Download data: CEL
DataSet
Accession:
GDS5660
ID:
5660
2.

Early postnatal expression data from mouse skeletal muscle stem cells

(Submitter supplied) Satellite cells are the primary source of stem cells for skeletal muscle growth and regeneration. Since adult stem cell maintenance involves a fine balance between intrinsic and extrinsic mechanisms, we performed genome-wide chronological expression profiling to identify the transcriptomic changes involved during early postnatal growth till acquisition of satellite cell quiescence.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5660
Platform:
GPL1261
11 Samples
Download data: CEL
Series
Accession:
GSE65927
ID:
200065927
3.

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M

(Submitter supplied) Regeneration of skeletal muscle is dependent on the function of tissue-resident muscle stem cells (MuSC), known as satellite cells. MuSC dysfunction is central to muscle pathophysiology, including in age-associated loss of muscle regenerative capacity and congenital disorders such as Duchenne muscular dystrophy. Despite the central role of satellite cells in muscle regeneration, the signals controlling the balance between muscle stem cell quiescence, proliferation, and differentiation remain incompletely understood. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL
Series
Accession:
GSE69976
ID:
200069976
4.

Expression data from murine myogenic cells

(Submitter supplied) Skeletal muscle has great regenerative capacity, which is dependent on muscle stem cells, also known as satellite cells. We established the purification system of myogenic cells. We used microarrays to identify specific genes during the muscle regenerative process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
4 Samples
Download data
Series
Accession:
GSE56903
ID:
200056903
5.

Notch signaling/MyoD double deficient embryonic muscle progenitors

(Submitter supplied) Skeletal muscle growth and regeneration rely on myogenic progenitor and satellite cells, the stem cells of postnatal muscle. Elimination of Notch signals during mouse development results in premature differentiation of myogenic progenitors and formation of very small muscle groups. Here we show that this drastic effect is rescued by mutation of the muscle differentiation factor MyoD. However, rescued myogenic progenitors do not assume a satellite cell position and contribute poorly to myofiber growth. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
47 Samples
Download data: TXT
Series
Accession:
GSE39379
ID:
200039379
6.

Genome wide expression analysis of FACS-isolated Shp2 mutant neonatal myogenic progenitor cells

(Submitter supplied) The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate muscle growth and repair. The non-receptor tyrosine phosphatase Shp2 (Ptpn11) is an important transducer of growth factor and cytokine signaling. Here we combined complex genetic analyses, biochemical studies and pharmacological interference to demonstrate a central role of Shp2 in postnatal myogenesis of mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18965
13 Samples
Download data: TXT
Series
Accession:
GSE97430
ID:
200097430
7.

MicroRNA expression profiling of quiescent and activated muscle stem cells

(Submitter supplied) MicroRNA expression profiling during muscle stem cell activation. Quiescent muscle stem cells from uninjured muscles and activated muscle stem cells from injured muscles at indicated time points were isolated by FACS.
Organism:
Rattus norvegicus; Mus musculus
Type:
Other
Platforms:
GPL11637 GPL11636
24 Samples
Download data: TXT
Series
Accession:
GSE26780
ID:
200026780
8.

Gene profiling of quiescent and activated skeletal muscle satellite cells by an in vivo approach

(Submitter supplied) The satellite cell of skeletal muscle provides a paradigm for quiescent and activated tissue stem cell states. We have carried out transcriptome analyses by comparing satellite cells from adult skeletal muscles, where they are mainly quiescent, with cells from growing muscles, regenerating (mdx) muscles, or with cells in culture, where they are activated. Our study gives new insights into the satellite cell biology during activation and in respect with its niche. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE15155
ID:
200015155
9.

Combination of high-dimensional approaches for skeletal muscle tissue cartography

(Submitter supplied) The regenerative capacity of skeletal muscle relies on muscle stem cells (MuSCs, or satellite cells) and its niche interactions with different neighboring cells. To understand the cellular diversity within adult skeletal muscle tissue, we harvested mononuclear cells from hindlimb skeletal muscles, sorted into single cells and profiled them by single-cell RNA-seq. To further understand and compare the expression profile between MuSCs and a novel smooth-muscle/mesenchymal-like cells (SMMCs) population, we isolated the two cell types by FACS and profiled them respectively by bulk RNA-seq.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
13 Samples
Download data: CSV, TSV
Series
Accession:
GSE110878
ID:
200110878
10.

Skeletal muscle satellite cells, endothelial cells and single muscle fibers

(Submitter supplied) There is considerable crosstalk between satellite cells, endothelilal cells and muscle fibers. Transcriptome analysis from freshly isolated cells from each compartment should help elucidate these pathways.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: BIGWIG, CSV, TXT
Series
Accession:
GSE108739
ID:
200108739
11.

Transcriptional profiling of embryonic skeletal muscle stem/progenitor cells

(Submitter supplied) Muscle stem cells (MuSC) change molecular and functional properties during development. Using a transgenic Tg:Pax7-nGFP mice, we FACS-isolated MuSC from embryonic (E12.5) and foetal (E17.5) stages to understand the differences and similarities amongst the myogenic stem/progenitor populations.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE52192
ID:
200052192
12.

Dynamic binding of RBPJ is determined by Notch signalling status

(Submitter supplied) Notch signalling plays crucial roles in mediating cell fate choices in all metazoans largely by specifying the transcriptional output of one cell in response to a neighbouring cell. The DNA-binding protein RBPJ is the principle effector of this pathway in mammals and together with the transcription factor moiety of Notch (NICD) it regulates the expression of target genes. The prevalent view presumes that RBPJ statically occupies consensus binding sites while exchanging repressors for activators in response to NICD. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL11002 GPL13112
33 Samples
Download data: BED, RPKM, WIG
Series
Accession:
GSE37184
ID:
200037184
13.

Comparison of Wild type and Pofut1-deleted skeletal muscle

(Submitter supplied) Pofut1 is an essential gene that glycosylates proteins containing EGF-like repeats, including Notch Receptors (NotchRs).  Work in mice and in Drosophila has shown that O-fucosylation by Pofut1 is required for NotchR ligands to bind to and activate NotchRs.  As such, Pofut1 deletion in skeletal myofibers allows for an analysis of potential functions and molecular changes of Pofut1 in skeletal muscle that derive from its expression in skeletal myofibers. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE80145
ID:
200080145
14.

Pharyngeal Satellite Cell Expression Profile

(Submitter supplied) To compare the differential gene expression between sorted satellite cells collected from pharyngeal verses limb muscle.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: IDAT, TXT
Series
Accession:
GSE69418
ID:
200069418
15.

Geriatric muscle stem cells switch reversible quiescence into senescence

(Submitter supplied) Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging and in progeric conditions. Here we show that geriatric satellite cells, compared to old cells, are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
36 Samples
Download data: TXT
Series
Accession:
GSE53728
ID:
200053728
16.

Geriatric muscle stem cells switch reversible quiescence into senescence (Set 4; Bmi1-deficient)

(Submitter supplied) Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline in geriatric satellite cells, compared to old cells are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
9 Samples
Download data: TXT
Series
Accession:
GSE53727
ID:
200053727
17.

Geriatric muscle stem cells switch reversible quiescence into senescence (Set 3; Adult vs. Young)

(Submitter supplied) Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging. We report that geriatric satellite cells, compared to old and adult cells, are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
6 Samples
Download data: TXT
Series
Accession:
GSE53726
ID:
200053726
18.

Geriatric muscle stem cells switch reversible quiescence into senescence (Set 2; Old/Geriatric vs. Young and SAMR1 vs. SAMP8)

(Submitter supplied) Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging and in progeric conditions. Here we report that geriatric satellite cells, compared to old cells, are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
14 Samples
Download data: TXT
Series
Accession:
GSE53725
ID:
200053725
19.

Geriatric muscle stem cells switch reversible quiescence into senescence (Set 1; Geriatric vs. Young)

(Submitter supplied) Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging. Here we report that geriatric satellite cells, compared to old cells, are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
7 Samples
Download data: TXT
Series
Accession:
GSE53724
ID:
200053724
20.

Increased activity of canonical NF-kB signaling in muscle fibers alters the satellite cell niche and restrains muscle stem cell function during aging

(Submitter supplied) It has been known for some time that muscle repair potential becomes increasingly compromised with advancing age, and that this age-related defect is associated with reduced activity of muscle satellite cells and with the presence of chronic, low grade inflammation in the muscle. Working from the hypothesis that a heightened inflammatory tone in aged muscle could contribute to poor regenerative capacity, we developed genetic systems to inducibly alter inflammatory gene expression in satellite cells or muscle fibers by modulation of the activity of nuclear factor κB (NF-κB), a master transcriptional regulator of inflammation whose activity is upregulated in many cell types and tissues with age. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
7 Samples
Download data: CEL, CHP
Series
Accession:
GSE72179
ID:
200072179
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