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Links from GEO DataSets

Items: 13

1.
Full record GDS5672

Anti-VEGF and Anti-Notch treatment effect on U87 glioblastoma xenograft tumors [HG-U133_Plus_2]

Analysis of U87 human xenograft tumors (in BALB/c SCID mouse host) treated with antiangiogenic agents bevacizumab (anti-VEGF) and dibenzazepine (anti-Notch). The tumors include mouse host stroma. Results, together with those from GDS5678, provide insight into molecular basis of tumor angiogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL570
Series:
GSE39223
9 Samples
Download data: CEL
2.

Regulation of gene expressions in vivo by anti-VEGF and anti-Notch therapy [Mouse430_2]

(Submitter supplied) U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, or dibenzazepine (DBZ) when tumour is established in BALB/c SCID mice. At the end point, collect tumour samples and extracted total RNA for microarray to investigate the gene profile changes compared to control. These include the genes from human tumour cells and mouse host stroma cells.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5678
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE39413
ID:
200039413
3.

Regulation of gene expressions in vivo by anti-VEGF and anti-Notch therapy [HG-U133_Plus_2]

(Submitter supplied) U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, or dibenzazepine (DBZ), when tumour is established in BALB/c SCID mice. At the end point, collect tumour samples and extracted total RNA for microarray to investigate the gene profile changes compared to control. These include the genes from human tumour cells and mouse host stroma cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5672
Platform:
GPL570
9 Samples
Download data: CEL
Series
Accession:
GSE39223
ID:
200039223
4.

Regulation of gene expressions in vivo by anti-VEGF therapy

(Submitter supplied) U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, when tumour is established in BALB/c SCID mice. At the end point, collect tumour samples and extracted total RNA for microarray to investigate the gene profile changes compared to control. These include the genes from human tumour cells and mouse host stroma cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE37956
ID:
200037956
5.
Full record GDS5678

Anti-VEGF and Anti-Notch treatment effect on U87 glioblastoma xenograft tumors [Mouse430_2]

Analysis of U87 human xenograft tumors (in BALB/c SCID mouse host) treated with antiangiogenic agents bevacizumab (anti-VEGF) and dibenzazepine (anti-Notch). The tumors include mouse host stroma. Results, together with those from GDS5672, provide insight into molecular basis of tumor angiogenesis.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL1261
Series:
GSE39413
14 Samples
Download data: CEL
6.

Lymphatic endothelium of metastatic tumours has a distinct transcription profile.

(Submitter supplied) Invasion of lymphatic vessels is a key step in the metastasis of primary tumour cells to draining lymph nodes. Recent evidence indicates that such metastasis can be facilitated by tumour lymphangiogenesis, although it remains unclear whether this is a consequence of increased lymphatic vessel numbers or alteration in the properties of the vessels themselves. Here we have addressed this important question by comparing the RNA profile of normal dermal lymphatic endothelial cells (LEC) with those isolated from tumours of murine T-241/VEGF-C metastatic fibrosarcoma. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE6255
ID:
200006255
7.

Expression profiling after ICAP1 or constitutive active NOTCH1 over expression in human umbilical vein endothelial cells

(Submitter supplied) ICAP1 (also known as ITG1BP1) is a protein interaction partner of beta1-integrins and the cerebral cavernous malformation protein 1 (CCM1, also known as KRIT1). In mice Icap1 plays an important role for bone development. The function of ICAP1 in endothelial cells is poorly understood. However, the interactions with beta1-integrins and CCM1 suggest that ICAP1 should play an important role also in endothelial cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
6 Samples
Download data: TXT
Series
Accession:
GSE18035
ID:
200018035
8.

Expression data from colon fibroblasts treated with Sonic hedgehog homolog (SHH)

(Submitter supplied) Canonical Hedgehog (Hh) signaling regulates the expression of genes that are critical to the patterning and development of a variety of organ systems. In adult, both ligand-dependent and ligand-independent Hh pathway activation are known to promote tumorigenesis. Recent studies have shown that in tumors promoted by Hh ligand, activation occurs within the stromal microenvironment (Yauch et al., 2009). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4512
Platform:
GPL570
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE29316
ID:
200029316
9.
Full record GDS4512

Sonic hedgehog homolog-stimulated fibroblasts

Analysis of CCD-18Co colon myofibroblasts stimulated with Sonic hedgehog homolog (SHH) for 72hr. Hedgehog (Hh)-driven, CCD-18Co proangiogenic signals drive tumor angiogenesis in vitro and in vivo. Results provide insight into the molecular mechanisms underlying Hh regulation of tumor angiogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL570
Series:
GSE29316
6 Samples
Download data: CEL
10.

Single-cell transcriptome analyses reveal endothelial cell heterogeneity in tumors and changes following anti-angiogenic treatment

(Submitter supplied) To understand tumor stromal cell heterogeneity focusing on tumor endothelial cells and tumor-associated fibroblasts, we isolated single cells from COLO205 tumor xenograft grown sub-cutaneously in SCID mice. To enrich stromal cell content, we removed vast majority of tumor cells by a depletion protocol using anti-CD24 and anti-E-Cadherin antibodies. The remaining single cells were profiled by single cell RNAseq
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19415 GPL19057
16 Samples
Download data: GTF, TXT
Series
Accession:
GSE110501
ID:
200110501
11.

Egr-1 induced gene expression changes in HUVECs

(Submitter supplied) The target genes of the transcription factor early growth response-1 (EGR-1) were studied in human umbilical vein endothelial cells (HUVEC). Densely cultured HUVEC were infected with recombinant adenoviruses expressing EGR-1 or empty control viruses at a MOI of 100. RNA was isolated from the cells at the time points 16 h, 24 h and 48 h post infection. Control cells without infection were cultured in parallel and harvested at the 24 h time point. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2008 GDS2009
Platforms:
GPL96 GPL97
14 Samples
Download data
Series
Accession:
GSE2299
ID:
200002299
12.
Full record GDS2009

Sustained EGR1 expression in endothelial cells: time course (HG-U133B)

Analysis of umbilical vein endothelial cells (HUVEC) at various time points up to 48 hours following transfection with a recombinant adenovirus expressing early growth response-1 (EGR1). EGR1 is implicated in cell growth, apoptosis, and differentiation. Results identify potential EGR1 target genes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 infection, 3 time sets
Platform:
GPL97
Series:
GSE2299
7 Samples
Download data
13.
Full record GDS2008

Sustained EGR1 expression in endothelial cells: time course (HG-U133A)

Analysis of umbilical vein endothelial cells (HUVEC) at various time points up to 48 hours following transfection with a recombinant adenovirus expressing early growth response-1 (EGR1). EGR1 is implicated in cell growth, apoptosis, and differentiation. Results identify potential EGR1 target genes.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 infection, 3 time sets
Platform:
GPL96
Series:
GSE2299
7 Samples
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