Similar studies for GEO DataSets (Select 5804) - GEO DataSets

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Items: 15

Select item 58041.

PI3K/mTOR Inhibitor NVP-BEZ235 and taxotere effects on prostate cancer xenograft tumors

Analysis of DU145 xenograft tumors in NOD/SCID mice treated with NVP-BEZ235, taxotere, or both. NVP-BEZ235 targets prostate cancer progenitor cells. Taxotere targets the bulk tumor. Results provide insight into potential biomarkers associated with cancer stem cells in these xenograft tumors.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 agent sets

Platform:: GPL570
Series:: GSE49232
4 Samples

Download data: CEL

DataSet

Accession:: GDS5804

ID:: 5804

Select item 2000539022.

Comparative analysis of gene expression of radioresistant prostate cancer cells and prostate cancer progenitors

(Submitter supplied) By employing a global gene expression profiling, we performed analysis of the molecular pathways which are deregulated in DU145 ALDH+ prostate cancer progenitors and DU145-RR radioresistant cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
18 Samples

Download data: TXT

Series

Accession:: GSE53902

ID:: 200053902

Select item 2000492323.

Gene expression analysis of in vivo-grown tumors treated with compounds that either de-bulk the tumor or target cancer stem cells

(Submitter supplied) A large body of evidence has demonstrated that many human tumors are maintained by a small cell population called cancer stem cells (CSCs) or tumor progenitors, which are responsible for tumor formation, therapy resistance and metastasis. We found that ionizing radiation treatment enriches for the CSC phenotype and properties by preferential survival and expansion of tumor progenitor cells. Our studies revealed that aldehyde dehydrogenase (ALDH) activity is indicative of prostate tumor progenitor cells with increased chemo- and radioresistance, enhanced migratory potential, improved DNA- double strand break repair and activation of the signaling pathways, which promote self-renewal and epithelial-mesenchymal transition. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5804
Platform:: GPL570
4 Samples

Download data: CEL

Series

Accession:: GSE49232

ID:: 200049232

Select item 2000537594.

Genomic characterization of ovarian cancer spheroids

(Submitter supplied) Spheroids are 3D multi-cell aggregates formed in non-addherent culture conditions. In ovarian cancer (OC), they serve as a vehicle for cancer cell dissemination in the peritoneal cavity. We investigated genes and networks upregulated in three dimensional (3D) versus two-dimensional (2D) culture conditions by Affymetrix gene expression profiling and identified ALDH1A1, a cancer stem cell marker as being upregulated in OC spheroids. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
9 Samples

Download data: CEL

Series

Accession:: GSE53759

ID:: 200053759

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001345005.

DNA copy number alteration analysis and gene expression profiles comparing radioresistant to radiosensitive prostate cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by array

Platforms:: GPL17077 GPL11357
16 Samples

Download data: TXT

Series

Accession:: GSE134500

ID:: 200134500

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001344996.

Comparative analysis of gene expression profiles comparing radioresistant to radiosensitive prostate cancer cell lines

(Submitter supplied) Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. Gene expression profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
12 Samples

Download data: TXT

Series

Accession:: GSE134499

ID:: 200134499

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001344987.

DNA copy number alteration analysis of radioresistant and radiosensitive prostate cancer cell lines

(Submitter supplied) Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. aCGH profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured and compared to normal DNA.

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platform:: GPL11357
4 Samples

Download data: TXT

Series

Accession:: GSE134498

ID:: 200134498

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000040898.

DNA methyltransferase inhibitor 5-aza-dC-treated prostate cancer cell lines

(Submitter supplied) This microarray dataset accompanies the publication by Kim et al, "The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer". The dataset comprises four prostate cancer cell lines treated with the DNA methyltransferase inhibitor 5-aza-dC. For each cell line, gene expression in treated (channel 2; Cy5) and untreated (channel 1; Cy3) cells is directly compared by hybridization to the same DNA microarray. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1697
Platform:: GPL3295
4 Samples

Download data

Series

Accession:: GSE4089

ID:: 200004089

Select item 2000029329.

Prostate_5azadC

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL2624
4 Samples

Download data

Series

Accession:: GSE2932

ID:: 200002932

Select item 169710.

DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine effect on prostate cancer cell lines

Analysis of prostate cancer cell lines after treatment with the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-aza-dC). Aberrant DNA methylation is an early event in the development of prostate cancer. Results identify hypermethylated genes whose expression is induced by 5-aza-dC.

Organism:: Homo sapiens

Type:: Expression profiling by array, log2 ratio, 4 cell line sets

Platform:: GPL3295
Series:: GSE4089
4 Samples

Download data

DataSet

Accession:: GDS1697

ID:: 1697

Select item 20019396311.

RNASeq analysis of human ALDH- and ALDH+ DU145 xenografts in nu/nu mice upon radiotherapy treatment

(Submitter supplied) Purpose: we aimed at identify and compare the transcriptional changes of ALDH- and ALDH+ DU145 xenografts upon radiotherapy treatment. Method: Xenografts were generated by injection of ALDH- and ALDH+ DU145 cells in male NMRI-Foxn1 nu/nu immune-deficient mice and subjected to fractionated irradiation to a final dose of 50 Gy. Tumors were excised and processed for total RNA extraction and RNAseq analysis.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data: CSV

Series

Accession:: GSE193963

ID:: 200193963

Select item 20012353012.

Evaluation of gene expression between ALDH-high and ALDH-low cells in endometrial cancer-derived spheroids

(Submitter supplied) To identify genes that are differentially expressed between ALDH-high and ALDH-low cells in endometrial cancer-derived spheroids, we performed whole genome microarray expression profiling as a discovery platform. Human endometrial cancer stem spheroid cells from three patients were sorted into ALDH-high and ALDH-low cells using the FACS Aria II Cell Sorter. Total RNA extracted from the cells were labeled with Cy3 and used for microarray analyses with Agilent Whole Human Genome Oligo Microarrays.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21185
6 Samples

Download data: TXT

Series

Accession:: GSE123530

ID:: 200123530

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20019289913.

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity [methylation]

(Submitter supplied) Novel particle therapy was implemented into standard-of-care for cancer patients during the last years. However, experimental studies investigating cellular and molecular mechanisms are lacking although prognostic biomarker are urgently needed. The cancer stem cell (CSC)-related marker aldehyde dehydrogenase (ALDH) is known to impact on prostate cancer radiosensitivity through affecting defense against reactive oxygen species (ROS), reducing DNA damage repair and increasing cell survival. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL21145
18 Samples

Download data: CSV, IDAT

Series

Accession:: GSE192899

ID:: 200192899

PubMed Similar studies

Select item 20019281714.

Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20844
52 Samples

Download data: TXT

Series

Accession:: GSE192817

ID:: 200192817

Select item 20015028315.

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations

(Submitter supplied) Many high-grade serous carcinomas (HGSCs) likely originate in the distal region of the Fallopian tube's epithelium (TE) before metastasizing to the ovary. Unfortunately, molecular mechanisms promoting malignancy in the distal TE are obfuscated, largely due to limited primary human TE gene expression data. Here we report an in depth bioinformatic characterization of 34 primary TE mRNA-seq samples. These samples were prepared from proximal and distal TE regions of 12 normal Fallopian tubes. more...