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Links from GEO DataSets

Items: 14

1.
Full record GDS5804

PI3K/mTOR Inhibitor NVP-BEZ235 and taxotere effects on prostate cancer xenograft tumors

Analysis of DU145 xenograft tumors in NOD/SCID mice treated with NVP-BEZ235, taxotere, or both. NVP-BEZ235 targets prostate cancer progenitor cells. Taxotere targets the bulk tumor. Results provide insight into potential biomarkers associated with cancer stem cells in these xenograft tumors.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL570
Series:
GSE49232
4 Samples
Download data: CEL
DataSet
Accession:
GDS5804
ID:
5804
2.

Comparative analysis of gene expression of radioresistant prostate cancer cells and prostate cancer progenitors

(Submitter supplied) By employing a global gene expression profiling, we performed analysis of the molecular pathways which are deregulated in DU145 ALDH+ prostate cancer progenitors and DU145-RR radioresistant cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
18 Samples
Download data: TXT
Series
Accession:
GSE53902
ID:
200053902
3.

Gene expression analysis of in vivo-grown tumors treated with compounds that either de-bulk the tumor or target cancer stem cells

(Submitter supplied) A large body of evidence has demonstrated that many human tumors are maintained by a small cell population called cancer stem cells (CSCs) or tumor progenitors, which are responsible for tumor formation, therapy resistance and metastasis. We found that ionizing radiation treatment enriches for the CSC phenotype and properties by preferential survival and expansion of tumor progenitor cells. Our studies revealed that aldehyde dehydrogenase (ALDH) activity is indicative of prostate tumor progenitor cells with increased chemo- and radioresistance, enhanced migratory potential, improved DNA- double strand break repair and activation of the signaling pathways, which promote self-renewal and epithelial-mesenchymal transition. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5804
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE49232
ID:
200049232
4.

Genomic characterization of ovarian cancer spheroids

(Submitter supplied) Spheroids are 3D multi-cell aggregates formed in non-addherent culture conditions. In ovarian cancer (OC), they serve as a vehicle for cancer cell dissemination in the peritoneal cavity. We investigated genes and networks upregulated in three dimensional (3D) versus two-dimensional (2D) culture conditions by Affymetrix gene expression profiling and identified ALDH1A1, a cancer stem cell marker as being upregulated in OC spheroids. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE53759
ID:
200053759
5.

DNA copy number alteration analysis and gene expression profiles comparing radioresistant to radiosensitive prostate cancer cell lines

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by array
Platforms:
GPL11357 GPL17077
16 Samples
Download data: TXT
Series
Accession:
GSE134500
ID:
200134500
6.

Comparative analysis of gene expression profiles comparing radioresistant to radiosensitive prostate cancer cell lines

(Submitter supplied) Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. Gene expression profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
12 Samples
Download data: TXT
Series
Accession:
GSE134499
ID:
200134499
7.

DNA copy number alteration analysis of radioresistant and radiosensitive prostate cancer cell lines

(Submitter supplied) Prostate cancer cell lines DU145 and LNCaP were purchased from the American Type Culture Collection. Radioresistant (RR) sublines were generated form these original parental radiosensitive (RS) cell lines. aCGH profiles of radiosensitive (RS) and radioresistant (RR) prostate cancer cell lines were measured and compared to normal DNA.
Organism:
Homo sapiens
Type:
Genome variation profiling by array
Platform:
GPL11357
4 Samples
Download data: TXT
Series
Accession:
GSE134498
ID:
200134498
8.

Inhibition of Androgen Receptor and β-catenin activity in prostate cancer

(Submitter supplied) Androgen receptor (AR) is the major therapeutic target in aggressive prostate cancer. However, targeting AR alone can result in drug resistance and disease recurrence. Therefore, simultaneous targeting of multiple pathways could in principle be an effective new approach to treating prostate cancer. Here we provide proof-of-concept that a small molecule inhibitor of nuclear β-catenin activity (called C3) can inhibit both the AR and β-catenin signaling pathways that are often misregulated in prostate cancer. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL10999
10 Samples
Download data: XLS
Series
Accession:
GSE49295
ID:
200049295
9.

ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancer

(Submitter supplied) Chromosomal translocations juxtaposing the androgen-responsive TMPRSS2 promoter with the ETS-family transcription factor ERG result in aberrant ERG up-regulation in approximately 50% of prostate cancers. Studies to date have demonstrated important roles of ERG in inducing oncogenic properties of prostate cancer. Its molecular mechanisms of action, however, are yet to be fully understood. To address these questions, we generated engineered LNCaP cells with ERG overexpression followed by LEF1 knockdown as well as control cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
5 Samples
Download data: TXT
Series
Accession:
GSE47423
ID:
200047423
10.

DNA methyltransferase inhibitor 5-aza-dC-treated prostate cancer cell lines

(Submitter supplied) This microarray dataset accompanies the publication by Kim et al, "The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer". The dataset comprises four prostate cancer cell lines treated with the DNA methyltransferase inhibitor 5-aza-dC. For each cell line, gene expression in treated (channel 2; Cy5) and untreated (channel 1; Cy3) cells is directly compared by hybridization to the same DNA microarray. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1697
Platform:
GPL3295
4 Samples
Download data
Series
Accession:
GSE4089
ID:
200004089
11.

Prostate_5azadC

(Submitter supplied) This microarray dataset accompanies the publication by Kim et al, "The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer". The dataset comprises four prostate cancer cell lines treated with the DNA methyltransferase inhibitor 5-aza-dC. For each cell line, gene expression in treated (channel 2; Cy5) and untreated (channel 1; Cy3) cells is directly compared by hybridization to the same DNA microarray. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2624
4 Samples
Download data
Series
Accession:
GSE2932
ID:
200002932
12.
Full record GDS1697

DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine effect on prostate cancer cell lines

Analysis of prostate cancer cell lines after treatment with the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-aza-dC). Aberrant DNA methylation is an early event in the development of prostate cancer. Results identify hypermethylated genes whose expression is induced by 5-aza-dC.
Organism:
Homo sapiens
Type:
Expression profiling by array, log2 ratio, 4 cell line sets
Platform:
GPL3295
Series:
GSE4089
4 Samples
Download data
DataSet
Accession:
GDS1697
ID:
1697
13.

Evaluation of gene expression between ALDH-high and ALDH-low cells in endometrial cancer-derived spheroids

(Submitter supplied) To identify genes that are differentially expressed between ALDH-high and ALDH-low cells in endometrial cancer-derived spheroids, we performed whole genome microarray expression profiling as a discovery platform. Human endometrial cancer stem spheroid cells from three patients were sorted into ALDH-high and ALDH-low cells using the FACS Aria II Cell Sorter. Total RNA extracted from the cells were labeled with Cy3 and used for microarray analyses with Agilent Whole Human Genome Oligo Microarrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21185
6 Samples
Download data: TXT
Series
Accession:
GSE123530
ID:
200123530
14.

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations

(Submitter supplied) Many high-grade serous carcinomas (HGSCs) likely originate in the distal region of the Fallopian tube's epithelium (TE) before metastasizing to the ovary. Unfortunately, molecular mechanisms promoting malignancy in the distal TE are obfuscated, largely due to limited primary human TE gene expression data. Here we report an in depth bioinformatic characterization of 34 primary TE mRNA-seq samples. These samples were prepared from proximal and distal TE regions of 12 normal Fallopian tubes. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
34 Samples
Download data: TSV
Series
Accession:
GSE150283
ID:
200150283
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