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Links from GEO DataSets

Items: 18

1.
Full record GDS5818

Normal liver developmental stages: embryonic and postnatal

Analysis of hepatoblasts, immature hepatocytes and hepatocytes from livers at different developmental timepoints (embryonic day 14, embryonic day 18, post-natal day 5, post-natal day 56). Results provide insight into molecular mechanisms underlying normal liver development.
Organism:
Mus musculus
Type:
Expression profiling by array, log2 ratio, 4 age, 3 cell type, 2 development stage sets
Platform:
GPL7202
Series:
GSE65063
11 Samples
Download data: TXT
2.

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma

(Submitter supplied) Genomic analysis of human hepatocellular carcinoma (HCC) is potentially confounded by the differentiation state of the hepatic cell-of-origin. Here we integrated genomic analysis of mouse HCC (with defined cell-of-origin) along with normal liver development. We found a major shift in expression of Wnt and RXR-α pathway genes (up and down, respectively) coincident with the transition from hepatoblasts to hepatocytes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5818
Platform:
GPL7202
11 Samples
Download data: TXT
Series
Accession:
GSE65063
ID:
200065063
3.

Expression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice

(Submitter supplied) Mouse liver tumors (T) and non tumoral adjacent livers (NT) sorted from mice knock out for Axin1 gene specifically in the hepatocytes . 3 mice of the brother hood non deleted for Axin1 were used as controls (WT) We used microarrays to determine the differential expression between tumoral and non tumoral tissue.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18802
16 Samples
Download data: CEL
Series
Accession:
GSE107374
ID:
200107374
4.

Oncogenic Serine-Threonine Kinase Receptor Associated Protein Supports Hepatocellular Carcinoma Cell Growth by Enhancing Wnt/β-catenin Signaling

(Submitter supplied) Serine-threonine kinase receptor-associated protein (STRAP) is upregulated in breast, colorectal and lung cancers, promoting their growth. We identify the upregulation of STRAP in hepatocellular carcinomas. Elevated STRAP endows tumor cells with growth advantage by reprograming a variety of metabolic processes and signaling pathways critical for hepatocellular carcinoma progression. Especially, enhanced Wnt/β-catenin signaling is likely to be a major effector of its tumor-promoting role.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
12 Samples
Download data: XLSX
Series
Accession:
GSE101061
ID:
200101061
5.

Delineation of EZH2 oncogenic functions in hepatocellular carcinoma

(Submitter supplied) The goal of this study was to delineate the important EZH2 direct target genes that mediate the oncogenic properties of EZH2 in HCC. The EZH2 direct target genes in two HCC cell lines were identified by chromatin immunoprecipitation microarray (ChIP-chip) analysis and later confirmed by independent ChIP-PCR. The functions of the target genes were further examined.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL4125 GPL4124
8 Samples
Download data: TXT
Series
Accession:
GSE17733
ID:
200017733
6.

Global analysis of genes regulated by canonical Wnt pathway

(Submitter supplied) Up-regulation of canonical Wnt signaling has been implicated in liver fibrosis and cancer. To determine canonical Wnt target genes potentially implicated in these diseases, we performed microarray analysis of culture-activated rat hepatic stellate cells (HSCs) treated with canonical Wnt inhibitors, DKK-1, ICG-001, or FJ9.
Organism:
Rattus norvegicus; Rattus norvegicus albus
Type:
Expression profiling by array
Platform:
GPL6247
6 Samples
Download data: CEL
Series
Accession:
GSE76330
ID:
200076330
7.

Gene expression profiling of the human HepaRG hepatocellular carcinoma cell line under WNT3A stimulation.

(Submitter supplied) The aim of the study was to characterize at a molecular level (changes in mRNA level) the effects of WNT3A on the human HepaRG hepatocellular carcinoma cell line. This was adressed by culturing HepaRG cells in presence or absence of Wnt3a.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
24 Samples
Download data: TXT
Series
Accession:
GSE68633
ID:
200068633
8.

Hepatoma cell lines vs. Universal control 3

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2913
36 Samples
Download data
Series
Accession:
GSE3536
ID:
200003536
9.

Hepatoma cell lines vs. Universal control 2

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2912
18 Samples
Download data
Series
Accession:
GSE3511
ID:
200003511
10.

Hepatoma cell lines vs. Universal control

(Submitter supplied) Gene expression profiles in hepatoma cells Keywords: Cell type comparison
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2911
18 Samples
Download data
Series
Accession:
GSE3444
ID:
200003444
11.

Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma (HT-HG_U133A)

(Submitter supplied) Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4269
Platform:
GPL3921
4 Samples
Download data: CEL
Series
Accession:
GSE10393
ID:
200010393
12.

Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma

(Submitter supplied) Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
118 Samples
Download data: TXT
Series
Accession:
GSE10186
ID:
200010186
13.
Full record GDS4269

Transforming growth factor-beta effect on Hepatocellular carcinoma Huh-7 cell line

Analysis of Hepatocellular carcinoma (HCC) Huh-7 cells stimulated with transforming growth factor-beta (TGF-β). HCC cell line Huh-7 has intact WNT pathway components. Results provide insight into the role of TGF-β in regulating WNT pathway activity in HCC cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL3921
Series:
GSE10393
4 Samples
Download data: CEL
14.

Niclosamide ethanolamine reverses gene expression and inhibits growth of hepatocellular carcinoma in vitro and in vivo

(Submitter supplied) Hepatocellular carcinoma (HCC) is a fatal malignancy with a dismal prognosis. The recent advances in genomics and transcriptomics have led to large volumes of molecular data for HCC, providing an unprecedented opportunity to translate these data into more effective therapeutics. By creating HCC gene expression signatures and comparing with drug response signatures from multiple datasets, we identified four antihelminthics (from over 1000 FDA-approved drugs) that can reverse the HCC disease gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
9 Samples
Download data: TXT
Series
Accession:
GSE77322
ID:
200077322
15.

Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL20301 GPL21103
30 Samples
Download data: TAB
Series
Accession:
GSE140463
ID:
200140463
16.

Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis - PART 2 (Human HCC - "Fatty Liver" background)

(Submitter supplied) The scope of this project is to study, using state-of-the-art systems biology approaches integrating the changes in metabolomics, lipidomics and transcriptomics, changes in hepatocytes' metabolism occurring in human HCC. We focused on altered metabolic pathways including lipogenesis, fatty acid desaturation, and generation of phosphatidylcholine (PC) occurring in HCC vs. paired HCC-free tissue.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
14 Samples
Download data: TAB
Series
Accession:
GSE140462
ID:
200140462
17.

Multifaceted rewiring of the hepatic lipidome during proliferation and carcinogenesis - PART 1 (Liver Regeneration)

(Submitter supplied) The scope of this project is to study, using state-of-the-art systems biology approaches integrating the changes in metabolomics, lipidomics and transcriptomics, changes in hepatocytes' metabolism occurring in liver regeneration. We focused on altered metabolic pathways including lipogenesis, fatty acid desaturation, and generation of phosphatidylcholine (PC) occurring in the liver following partial hepatectomy (PH) or carbon-tetrachloride (CCl4) injection.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
16 Samples
Download data: TAB
Series
Accession:
GSE140461
ID:
200140461
18.

Studying diet induced liver carcinogenesis

(Submitter supplied) The scope of this project is to study, using state-of-the-art systems in the liver following den induced liver cancer with dietary modification (high fat diet and sugar water - HFD+SW).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: TAB
Series
Accession:
GSE140243
ID:
200140243
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