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Links from GEO DataSets

Items: 5

1.
Full record GDS5819

Metastatic breast cancer and sepsis: monocytes

Analysis of the total population of monocytes from patients with metastatic breast cancer (MBC), sepsis, or tuberculosis. Results provide insight into molecular similarities between monocytes from MBC patients and reprogrammed immunosuppressive monocytes from sepsis patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL10558
Series:
GSE65517
13 Samples
Download data
2.

Comparative analysis of monocytes from healthy donors, patients with metastatic breast cancer, sepsis or tuberculosis.

(Submitter supplied) Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenotype. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5819
Platform:
GPL10558
13 Samples
Download data: TXT
Series
Accession:
GSE65517
ID:
200065517
3.

Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth

(Submitter supplied) Analysis of MDSC subsets from naive blood and RMA-S blood and RMA-S tumor, respectively. Tumor-infiltrating MO-MDSCs changed their expression pattern compared to blood and exhibited high levels of chemokines
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6105
18 Samples
Download data: CSV, TXT
Series
Accession:
GSE41620
ID:
200041620
4.

Expression data from MDSCs at different time points during tumor progression

(Submitter supplied) Myeloid-derived suppressor cells (MDSCs) are increased by tumor-derived factors and suppress anti-tumor immunity. MDSCs obtained at a late time point after tumor injection had stronger suppressive activity than MDSCs obtained at an early time point, as measured by T cell proliferation assays. To find factors in MDSCs that change during tumor growth, we analyzed gene expression profiles from MDSCs at different time points after tumor injection. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
17 Samples
Download data: CEL
Series
Accession:
GSE35398
ID:
200035398
5.

Human G-MDSCs are Neutrophils at Distinct Maturation Stages that Promote Tumor Growth and Immune Cell Exclusion in Breast Cancer

(Submitter supplied) Myeloid-derived suppressor cells (MDSC) are known to contribute to immune evasion in cancer. However, the function of the human granulocytic (G)-MDSC subset during tumor progression is largely unknown, and there are no established markers for their identification in human tumor specimens. Using gene expression profiling, mass cytometry and tumor microarrays, we here demonstrate that human G-MDSCs occur as neutrophils at distinct maturation stages, with a disease-specific profile. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
12 Samples
Download data: CEL, CHP, XLS
Series
Accession:
GSE157737
ID:
200157737
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