Similar studies for GEO DataSets (Select 583) - GEO DataSets

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Items: 20

Select item 5831.

Examination of normal adult aging using synchronized populations at 0 - 144 hours. Employed CF512 fer-15(b26) II; fem-1 (hc17) IV mutant strain, which has defective spermatids thus eliminating contributions from embryonic transcripts.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, log ratio, 7 age sets

Platform:: GPL576
Series:: GSE832
7 Samples

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DataSet

Accession:: GDS583

ID:: 583

Select item 2000009462.

C. elegans heat stress time course

(Submitter supplied) We sought to study the effect of heat stress on gene expression in C. elegans. We cultured CF512 animals to adulthood at 25C (at which they are sterile). We then induced heat stress by switching the culture temperature to 30C. Keywords: time-course

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS584
Platform:: GPL924
7 Samples

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Series

Accession:: GSE946

ID:: 200000946

Select item 2000008323.

Adult aging in C. elegans

(Submitter supplied) We wished to study normal adult aging in C. elegans. We competitively hybridized a series of experimental samples (experimental variable: adult age) against a common reference sample. We use the CF512 fer-15(b26) II; fem-1 (hc17) IV mutant strain, which has defective spermatids which fail to activate into spermatozoa at 25C. Culturing this strain at 25C prevented self-fertilization and therefore eliminated contributions from embryonic transcripts. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS583
Platform:: GPL576
7 Samples

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Series

Accession:: GSE832

ID:: 200000832

Select item 2000008274.

Oxidative stess in Drosophila heads

(Submitter supplied) Profiled the effect of oxidative stress on gene expression in the heads of adult Drosophila. The flies were fed sucrose with 15mM paraquat (experimental condition) or regular sucrose (control condition) for 30 hours, before harvesting at adult d3. Keywords = oxidative stress Keywords = paraquat Keywords: dose response

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL72
2 Samples

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Series

Accession:: GSE827

ID:: 200000827

Select item 2000008265.

Aging in heads from adult Drosophila males, w118 strain

(Submitter supplied) The w1118 strain is an inbred lab stock widely used in genetic and transgenic studies. w1118 males have a median life span of 35 days. Adult males were collected within 24 hr after eclosion. Approximately 200 flies were maintained in constant darkness in each food bottle at 25°C and 70% humidity and were transferred to fresh bottles every 3-4 days. Transcripts were harvested at d3 and d47. To separate the head from the rest of the body, flies were frozen and briefly vortexed in liquid nitrogen. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL72
2 Samples

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Series

Accession:: GSE826

ID:: 200000826

Select item 5846.

Heat stress time course

Examination of effect of heat stress. Adult CF512 cultured at 25°C, then switched to 30°C and sampled over 12 hour time period.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, log ratio, 7 time sets

Platform:: GPL924
Series:: GSE946
7 Samples

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DataSet

Accession:: GDS584

ID:: 584

Select item 2000368387.

Expression profiling of the effect of high-fat diet, low-fat diet, CR and exercise on mice liver

(Submitter supplied) Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with diet-modulated lifespan and physiological changes were enriched for lifespan-modifying genes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
18 Samples

Download data: CEL

Series

Accession:: GSE36838

ID:: 200036838

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000368368.

Expression profiling of aging liver in low-fat diet mice

(Submitter supplied) Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. To determine how our dietary intervention-based transcriptomic approach for predicting aging-regulatory genes compares to more traditional approach of using age-dependent transcriptional changes, we examined the hepatic gene expression changes in LF-fed mice during aging at 4, 8, 13 and 21 months.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE36836

ID:: 200036836

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000040059.

Aging time course

(Submitter supplied) Transcriptional Profile of Aging in C. elegans Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1% of the genome). more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

5 related Platforms
26 Samples

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Series

Accession:: GSE4005

ID:: 200004005

Select item 20005766410.

Gene Expression Profiling Reveals Molecular Patterns Underlying the Lifespan-Extending Effect of Tyrosol in Caenorhabditis elegans

(Submitter supplied) We have previously reported that tyrosol (TYR), one of the main phenols in extra virgin olive oil (EVOO), promotes lifespan extension in the nematode Caenorhabditis elegans, also inducing a stronger resistance to thermal and oxidative stress in this animal model. Although the influence of several longevity-related genes in these effects has been reported by our group, we decided to perform a whole genome DNA-microarray approach in order to identify other genes and molecular pathways further involved in TYR effects on C. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
6 Samples

Download data: CEL

Series

Accession:: GSE57664

ID:: 200057664

Select item 20000176211.

C. elegans daf2 mutant adults

(Submitter supplied) Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity. Keywords: other

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS770
Platform:: GPL200
20 Samples

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Series

Accession:: GSE1762

ID:: 200001762

Select item 77012.

Long-lived daf-2 insulin/IGF-1 receptor mutant expression profiling

Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE1762
20 Samples

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DataSet

Accession:: GDS770

ID:: 770

Select item 20000264213.

Evolution of gene expression in the Drosophila melanogaster subgroup update and extension

(Submitter supplied) http://0-www-nature-com.brum.beds.ac.uk/ng/journal/v33/n2/abs/ng1086.html. Little is known about broad patterns of variation and evolution of gene expression during any developmental process. Here we investigate variation in genome-wide gene expression among Drosophila simulans, Drosophila yakuba and four strains of Drosophila melanogaster during a major developmental transition?the start of metamorphosis. Differences in gene activity between these lineages follow a phylogenetic pattern, and 27% of all of the genes in these genomes differ in their developmental gene expression between at least two strains or species. more...

Organism:: Drosophila simulans; Drosophila yakuba; Drosophila melanogaster

Type:: Expression profiling by array

5 related Platforms
48 Samples

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Series

Accession:: GSE2642

ID:: 200002642

Select item 20000032714.

Evolution of gene expression in the Drosophila melanogaster subgroup

(Submitter supplied) Little is known about broad patterns of variation and evolution of gene expression during any developmental process. Here we investigate variation in genome-wide gene expression among Drosophila simulans, Drosophila yakuba and four strains of Drosophila melanogaster during a major developmental transition-the start of metamorphosis. Differences in gene activity between these lineages follow a phylogenetic pattern, and 27% of all of the genes in these genomes differ in their developmental gene expression between at least two strains or species. more...