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Links from GEO DataSets

Items: 20

1.
Full record GDS599

Burn injury: liver metabolic and inflammatory response

Temporal analysis of metabolic and inflammatory response to burn injury. Livers from male Sprague-Dawleys examined at 1, 4, 8, and 24 hours following 20% total burn surface area scald-burn injury.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 5 time sets
Platform:
GPL85
Series:
GSE802
10 Samples
Download data
2.

Burn20

(Submitter supplied) Type of experiment: Comparison of liver samples between sham (control) and 20% TBSA (total burn surface area) burn rats collected at 1h, 4h, 8h, and 24h. Experimental factors: Burn injury and time Experiment design: All experimental liver samples collected after 1h, 4h, 8h, and 24h after burn injury were compared to a common reference (sham control treated as 0h time point) Bio source: Sprague-Drawley male rats weighing 150-200 g supplied through Charles river laboratories, MA (www.criver.com) Bio material manipulations: Rats (n=3 for each scald-burn and sham-burn time point) were individually housed in a temperature-controlled (25oC) and light-controlled room (12h light-dark cycle) and allowed to adjust to their new surroundings for at least 5 days prior to the experiment. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS599
Platform:
GPL85
10 Samples
Download data
Series
Accession:
GSE802
ID:
200000802
3.

Long Term Thermal Injury Analysis

(Submitter supplied) These samples comprise the full analysis of liver function during response to thermal injury. Keywords: Time Course
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
12 Samples
Download data
Series
Accession:
GSE5647
ID:
200005647
4.

Orotic acid induced fatty liver disease

(Submitter supplied) A time course of orotic acid induced fatty liver disease. Kyoto and Wistar strain rats were exposed to orotic acid for days 1, 3 and 14. Controls are also included. Keywords = Wistar Keywords = Kyoto Keywords = orotic acid Keywords: time-course
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS765
Platform:
GPL85
14 Samples
Download data
Series
Accession:
GSE665
ID:
200000665
5.
Full record GDS765

Fatty liver disease induced by orotic acid: time course

Expression profiling of livers from inbred Kyotos and outbred Wistars fed a diet with 1% orotic acid to induce fatty liver disease. Profiles examined at various time points up to 14 days. Results used together with NMR spectroscopic analysis of the liver to identify perturbed metabolic pathways.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 2 strain, 4 time sets
Platform:
GPL85
Series:
GSE665
18 Samples
Download data
DataSet
Accession:
GDS765
ID:
765
6.

Gene expression profile in human orthotopic liver transplantation

(Submitter supplied) We have studied the genes activated in human liver transplantation to identify potential target genes for the prevention or treatment of related injuries. In a first protocol, in order to evaluate the effect of Ischemia-Reperfusion Injury (IRI) on gene expression profile, we compared gene expression levels in transplanted-reperfused livers versus basal values in donor livers, identifying 795 genes significantly modified in human liver after transplantation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
15 Samples
Download data: CEL
Series
Accession:
GSE14951
ID:
200014951
7.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
8.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
9.

LPS Blood Time course

(Submitter supplied) cDNA microarray study of gene expression changes in whole blood from LPS treated rats, 2 and 6 hours after I.P. injection of 5 mg/kg Keywords: time-course
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1344
12 Samples
Download data: TIFF
Series
Accession:
GSE1658
ID:
200001658
10.

Rat liver response to Clofibrate, DEHP or VPA

(Submitter supplied) The project had 2 goals: 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis. Keywords = Clofibrate Keywords = Diethylhexyl phthalate Keywords = Phthalic acid bis(2-ethylhexyl ester) Keywords = Sodium Valproate Keywords = Valproic Acid Keywords = VPA Keywords = vehicle Keywords: other
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1451
Platform:
GPL85
94 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE2303
ID:
200002303
11.
Full record GDS1451

Toxicants effect on liver: pooled and individual sample comparison

Analysis of livers of Sprague-Dawley males at various time points up to 168 hours after treatment with clofibrate, diethylhexylphthalate, or valproic acid. Expression profiles from pooled and individual samples compared. Results provide insight into the impact of pooling on experimental analysis.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 agent, 2 protocol, 4 time sets
Platform:
GPL85
Series:
GSE2303
94 Samples
Download data: CEL, CHP, EXP
DataSet
Accession:
GDS1451
ID:
1451
12.

Chronic contusion spinal cord injury in rats

(Submitter supplied) Excerpt from a larger study which characterized the transcriptional effects of a spinal cord contusion injury in rats. This is the data from the almost chronic contusion state (35 days) at the injury site (Thoracic 8) - where we saw significant changes in several areas, including cholesterol metabolism genes. Other spinal cord areas (rostral, caudal) and time-points (3 hours, 24 hours, 7 days and 35 days) were analyzed as well and are discussed in our paper and at www.crpf.org/microarray. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1238
Platform:
GPL85
6 Samples
Download data
Series
Accession:
GSE2599
ID:
200002599
13.
Full record GDS1238

Spinal cord contusion

Expression profiling of contused spinal cords of Fischer animals. Spinal cords examined 35 days following contusion at the thoracic 8 segment. Results identify potential targets for therapeutic intervention following spinal cord injury.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 shock sets
Platform:
GPL85
Series:
GSE2599
6 Samples
Download data
DataSet
Accession:
GDS1238
ID:
1238
14.

Effect of Diabetes on Retinal Müller Cells

(Submitter supplied) Rat Retinal Müller cells from diabetic rats (diabetes duration 6 months) compared to Rat Retinal Müller cells from healthy rats. Diabetes was induced by streptozotozine. Diabetic rats were treated with small doses of insulin to prevent catabolism. Keywords: ordered
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
5 Samples
Download data: CEL, EXP
Series
Accession:
GSE1979
ID:
200001979
15.

Gene expression profiling in the lung and liver of low and high dose Perfluorooctanoic Acid exposed mouse fetuses

(Submitter supplied) Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, cholesterol biosynthesis, steroid metabolism, bile acid biosynthesis, phospholipid metabolism, retinol metabolism, proteosome activation, and inflammation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS3410 GDS3411
Platform:
GPL1261
59 Samples
Download data: CEL
Series
Accession:
GSE13044
ID:
200013044
16.
Full record GDS3411

Low doses of perfluorooctanoic acid effect on fetal liver and lung

Analysis of livers or lungs of fetuses dosed during gestation with up to 3 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 dose, 2 tissue sets
Platform:
GPL1261
Series:
GSE13044
29 Samples
Download data: CEL
DataSet
Accession:
GDS3411
ID:
3411
17.
Full record GDS3410

High doses of perfluorooctanoic acid effect on fetal liver and lung

Analysis of livers or lungs of fetuses dosed during gestation with up to 10 mg/(kg day) perfluorooctanoic acid (PFOA), an industrial chemical that induces growth deficits and mortality in murine neonates. Results provide insight into the molecular basis of PFOA-induced developmental toxicity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 dose, 2 tissue sets
Platform:
GPL1261
Series:
GSE13044
30 Samples
Download data: CEL
DataSet
Accession:
GDS3410
ID:
3410
18.

Burn-CLP

(Submitter supplied) The experimental design included three biological replicates for each of the three conditions: Sham-Sham, Sham-CLP and burn-CLP. Liver samples were collected from the rats and the total RNA was analyzed on a Affymetrix RAE230A chip. No technical replicates were included in the study Keywords: other
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2235
Platform:
GPL341
9 Samples
Download data
Series
Accession:
GSE1781
ID:
200001781
19.
Full record GDS2235

Burn sepsis model: liver

Analysis of livers of animals subjected to moderate burn injury followed two days later by cecum ligation and puncture (CLP) to produce sepsis. The dual insult induces a systemic hypermetabolic state. Results provide insight into regulation of the hypermetabolic response in the liver.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL341
Series:
GSE1781
9 Samples
Download data
20.

Comparison of Longitudinal Leukocyte Gene Expression after Burn Injury or Trauma Hemorrhage in Mice

(Submitter supplied) We report here the genes that are sequentially expressed in white blood cells from blood and spleen at 2 hours, 2 day,3 days, and 7 days after burn and sham injury or trauma-hemorrhage (T-H) and sham T-H. Includes WBC treated with LPS for 2 hours and 1 day.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
144 Samples
Download data: CEL, CHP, EXP
Series
Accession:
GSE7404
ID:
200007404
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