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Links from GEO DataSets

Items: 20

1.
Full record GDS6100

MicroRNA-135b overexpression effect on prostate cancer cell line: time course

Analysis of LNCaP prostate cancer (PCa) cells overexpressing miRNA-135b for up to 36 hours. LNCaP cells express the androgen receptor (AR). MiRNA-135b overexpression in AR+ PCa cells results in slower growth compared to AR knockdown. Results provide insight into the basis of this slower growth.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE57820
12 Samples
Download data
2.

The effect of miRNA-135b overexpression on the gene expression profile of LNCaP cells

(Submitter supplied) MicroRNAs (miRNAs) regulate a wide range of cellular signaling pathways and biological processes in both physiological and pathological states such as cancer. We have previously identified miR-135b as a direct regulator of androgen receptor (AR) protein level in prostate cancer (PCa). We wanted to further explore the relationship of miR-135b to hormonal receptors, particularly estrogen receptor α (ERα). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS6100
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE57820
ID:
200057820
3.

IL-1-conferred gene expression pattern in ERa+ BCa and AR+ PCa cells is intrinsic to ERa- BCa and AR- PCa cells and promotes cell survival

(Submitter supplied) Background: Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Estrogen receptor alpha (ERa) is overexpressed in 70% of diagnosed BCa patients and androgen receptor (AR) is overexpressed in 80-90% of diagnosed PCa patients. Thus, BCa and PCa patients are given therapy that reduces hormone levels or directly blocks HR activity; but most patients eventually develop treatment resistance. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
12 Samples
Download data: TAB
Series
Accession:
GSE136420
ID:
200136420
4.

Identification of an IL-1-induced gene expression pattern in AR+ PCa cells that mimics the molecular phenotype of AR- PCa cells

(Submitter supplied) In immunosurveillance, bone-derived immune cells infiltrate the tumor and secrete inflammatory cytokines to destroy cancer cells. However, cancer cells have evolved mechanisms to usurp inflammatory cytokines to promote tumor progression. In particular, the inflammatory cytokine, interleukin-1 (IL-1), is elevated in prostate cancer (PCa) patient tissue and serum and promotes PCa bone metastasis. IL-1 also represses androgen receptor (AR) accumulation and activity in PCa cells, yet the cells remain viable; suggesting that IL-1 may also contribute to AR-targeted therapy resistance. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
18 Samples
Download data: TAB
Series
Accession:
GSE105088
ID:
200105088
5.

Genome wide screen of estrogen receptor α regulated microRNAs reveals a negative autoregulatory feedback loop

(Submitter supplied) Estrogen receptor alpha (ERα) is a nuclear receptor linked to progression of the majority of human breast cancers. Following activation ERα regulates the transcription of target genes via DNA binding. Through a genome wide approach we have identified a subset of microRNAs (miRNAs or miRs) modulated by ERα. Among them, miRNAs encoded from 2 paralogous clusters, miR-17-92 and miR-106a-363, were up-regulated. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL6955
24 Samples
Download data
Series
Accession:
GSE14685
ID:
200014685
6.

Dynamics of intercellular and exosomal miRNAs in hypoxia-resistant cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL13987
18 Samples
Download data
Series
Accession:
GSE48983
ID:
200048983
7.

Dynamics of intercellular and exosomal miRNAs in hypoxia-resistant U266 cells

(Submitter supplied) In multiple myeloma (MM), abnormal plasma cells interact with bone marrow (BM) stromal cells and vascular cells among others. A part of the BM milieu is considered highly hypoxic, and myeloma cells in situ may be influenced by circumstances other than normoxia in vitro. Hence, we attempted to confirm the role of hypoxic MM-derived exosomes in the BM milieu. We established a novel hypoxia-resistant cell line, U266HR, derived from U266 cells cultured for >4 months under hypoxia (1% O2), as a model of MM cells localizing in an extensively hypoxic milieu. more...
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL13987
6 Samples
Download data: TXT
Series
Accession:
GSE48910
ID:
200048910
8.

Dynamics of intercellular and exosomal miRNAs in hypoxia-resistant RPMI8226 cells

(Submitter supplied) In multiple myeloma (MM), abnormal plasma cells interact with bone marrow (BM) stromal cells and vascular cells among others. A part of the BM milieu is considered highly hypoxic, and myeloma cells in situ may be influenced by circumstances other than normoxia in vitro. Hence, we attempted to confirm the role of hypoxic MM-derived exosomes in the BM milieu. We established a novel hypoxia-resistant cell line, RPMI8226HR, derived from RPMI8226 cells cultured for >4 months under hypoxia (1% O2), as a model of MM cells localizing in an extensively hypoxic milieu. more...
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL13987
6 Samples
Download data: TXT
Series
Accession:
GSE48909
ID:
200048909
9.

Dynamics of intercellular and exosomal miRNAs in hypoxia-resistant KMS-11 cells

(Submitter supplied) In multiple myeloma (MM), abnormal plasma cells interact with bone marrow (BM) stromal cells and vascular cells among others. A part of the BM milieu is considered highly hypoxic, and myeloma cells in situ may be influenced by circumstances other than normoxia in vitro. Hence, we attempted to confirm the role of hypoxic MM-derived exosomes in the BM milieu. We established a novel hypoxia-resistant cell line, KMS-11-HR, derived from KMS-11 cells cultured for >4 months under hypoxia (1% O2), as a model of MM cells localizing in an extensively hypoxic milieu. more...
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL13987
6 Samples
Download data: TXT
Series
Accession:
GSE48908
ID:
200048908
10.

Identification of miR-205 targets using an RIP-Chip assay with AGO2 antibody

(Submitter supplied) In this study, the prognostic properties of miR-205 expression levels are investigated in a well-documented prostate cancer cohort. We show that miR-205 is correlated to shortened overall survival, significantly dividing the PCa patients into high and low risk groups. Furthermore, miR-205 is shown to inversely correlate to occurrence of metastases. In situ hybridization is also performed, demonstrating high miR-205 expression in the basal cells of benign prostate tissue glands. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Other
Platform:
GPL6244
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE39735
ID:
200039735
11.

The effect of miRNA overexpression on gene expression profile of MCF-7 cells

(Submitter supplied) To identify microRNAs impacting estrogen receptor ERα expression in breast cancer, we have screened ER-positive breast cancer cells with a library of pre-miRs, and systematically monitored the ERα expression by protein lysate microarrays. There was a significant enrichment of the in silico predicted ERα targeting microRNAs among the hits. The most potent pre-miRs miR-18a/b, miR-193b, miR-206, and miR-302c, were confirmed to directly target ERα and to repress estrogen-responsive genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6102
11 Samples
Download data: TXT
Series
Accession:
GSE14847
ID:
200014847
12.

DHT-AR, E2-AR and R5020-AR target gene profiles in LNCaP

(Submitter supplied) We previously encountered regulatory processes where dihydrotestosterone (DHT) exerted its inhibitory effect on parathyroid hormone-related protein (PTHrP) gene repression through the estrogen receptor (ER)α, but not the androgen receptor (AR) in breast cancer MCF-7 cells. Here, we investigated whether such an aberrant ligand-nuclear receptor (NR) interaction is present in prostate cancer LNCaP cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
8 Samples
Download data: TXT
Series
Accession:
GSE58615
ID:
200058615
13.

ZR-75-1 microarray expression data

(Submitter supplied) Testing the hormonal response of ZR-75-1 cells to estrogen, androgens, and a combination of both homones, with view determining the crosstalk between the transcriptional programs mediated by these hormones in breast cancer cells, and comparison with matched ChIP sequencing data for AR and ERalpha. Data analysis demonstrated reciprocal interference between 5α-dihydrotestosterone (DHT)- and estradiol (E2)-induced transcriptional programs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
36 Samples
Download data: TXT
Series
Accession:
GSE38132
ID:
200038132
14.

SOCS2 expression correlates with tumor malignancy, exerts growth promoting effects and is enhanced by androgens in prostate cancer

(Submitter supplied) Deregulation of cytokine- and growth factor signaling due to altered expression of endogenous regulators is well recognized in prostate and other cancers. Suppressor of cytokine signaling 2 (SOCS2) is a key regulator of growth hormone, IGF and prolactin signaling, that have been implicated in carcinogenesis. In this study we elucidate expression pattern and functional significance of SOCS2 in prostate cancer (PCa). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17737
30 Samples
Download data: CEL
Series
Accession:
GSE50936
ID:
200050936
15.

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions

(Submitter supplied) The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR signalling. Treatment of advanced prostate cancer through medical or surgical castration leads to initial response and durable remission, but resistance inevitably develops. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL10999 GPL11154
35 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE40050
ID:
200040050
16.

The miR-96 and RARG signaling axis governs androgen signaling and prostate cancer progression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL10558 GPL11154
84 Samples
Download data
Series
Accession:
GSE117182
ID:
200117182
17.

The miR-96 and RARG signaling axis governs androgen signaling and prostate cancer progression VI

(Submitter supplied) Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RARG), are commonly reduced in prostate cancer (PCa). Therefore we sought to establish the cellular and gene regulatory consequences of reduced RARG expression, and determine RARG regulatory mechanisms. RARG shRNA approaches in non-malignant (RWPE-1 and HPr1-AR) and malignant (LNCaP) prostate models revealed that reducing RARG levels, rather than adding exogenous retinoid ligand, had the greatest impact on prostate cell viability and gene expression. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
18 Samples
Download data: BW
Series
Accession:
GSE117179
ID:
200117179
18.

The miR-96 and RARG signaling axis governs androgen signaling and prostate cancer progression V

(Submitter supplied) Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RARG), are commonly reduced in prostate cancer (PCa). Therefore we sought to establish the cellular and gene regulatory consequences of reduced RARG expression, and determine RARG regulatory mechanisms. RARG shRNA approaches in non-malignant (RWPE-1 and HPr1-AR) and malignant (LNCaP) prostate models revealed that reducing RARG levels, rather than adding exogenous retinoid ligand, had the greatest impact on prostate cell viability and gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
18 Samples
Download data: TXT
Series
Accession:
GSE117110
ID:
200117110
19.

The miR-96 and RARG signaling axis governs androgen signaling and prostate cancer progression IV

(Submitter supplied) Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RARG), are commonly reduced in prostate cancer (PCa). Therefore we sought to establish the cellular and gene regulatory consequences of reduced RARG expression, and determine RARG regulatory mechanisms. RARG shRNA approaches in non-malignant (RWPE-1 and HPr1-AR) and malignant (LNCaP) prostate models revealed that reducing RARG levels, rather than adding exogenous retinoid ligand, had the greatest impact on prostate cell viability and gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE117104
ID:
200117104
20.

The miR-96 and RARG signaling axis governs androgen signaling and prostate cancer progression III

(Submitter supplied) Expression levels of retinoic acid receptor gamma (NR1B3/RARG, encodes RARG), are commonly reduced in prostate cancer (PCa). Therefore we sought to establish the cellular and gene regulatory consequences of reduced RARG expression, and determine RARG regulatory mechanisms. RARG shRNA approaches in non-malignant (RWPE-1 and HPr1-AR) and malignant (LNCaP) prostate models revealed that reducing RARG levels, rather than adding exogenous retinoid ligand, had the greatest impact on prostate cell viability and gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE117103
ID:
200117103
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