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Links from GEO DataSets

Items: 17

1.
Full record GDS874

Spinal cord injury and regeneration time course: above T9 (RG-U34C)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 7 time sets
Platform:
GPL87
Series:
GSE464
48 Samples
Download data: CEL
DataSet
Accession:
GDS874
ID:
874
2.

CNS Regeneration

(Submitter supplied) Summary: Spinal cord injury (SCI) is a damage to the spinal cord induced by trauma or desease resulting in a loss of mobility or feeling. SCI is characterized by a primary mechanical injury followed by a secondary injury in which several molecular events are altered in the spinal cord often resulting in loss of neuronal function. Hypothesis: Spinal cord injury (SCI) induces a cascade of molecular events including the activation of genes associated with transcription factors, inflammation, oxidative stress, ionic imbalance, apoptosis and neuroregeneration which suggests the existance of endogenous reparative attempts. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS63 GDS259 GDS339 GDS869 GDS870 GDS871 GDS872 GDS873 GDS874
Platforms:
GPL85 GPL86 GPL87
544 Samples
Download data: CEL
Series
Accession:
GSE464
ID:
200000464
3.
Full record GDS873

Spinal cord injury and regeneration time course: above T9 (RG-U34B)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 7 time sets
Platform:
GPL86
Series:
GSE464
47 Samples
Download data: CEL
DataSet
Accession:
GDS873
ID:
873
4.
Full record GDS872

Spinal cord injury and regeneration time course: above T9 (RG-U34A)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord above thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 7 time sets
Platform:
GPL85
Series:
GSE464
52 Samples
Download data: CEL
DataSet
Accession:
GDS872
ID:
872
5.
Full record GDS871

Spinal cord injury and regeneration time course: below T9 (RG-U34C)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 6 time sets
Platform:
GPL87
Series:
GSE464
43 Samples
Download data: CEL
DataSet
Accession:
GDS871
ID:
871
6.
Full record GDS870

Spinal cord injury and regeneration time course: below T9 (RG-U34B)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol, 7 time sets
Platform:
GPL86
Series:
GSE464
52 Samples
Download data: CEL
DataSet
Accession:
GDS870
ID:
870
7.
Full record GDS869

Spinal cord injury and regeneration time course: below T9 (RG-U34A)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord below thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 7 time sets
Platform:
GPL85
Series:
GSE464
55 Samples
Download data: CEL
DataSet
Accession:
GDS869
ID:
869
8.
Full record GDS339

Spinal cord injury and regeneration time course: at T9 (RG-U34C)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 11 time sets
Platform:
GPL87
Series:
GSE464
75 Samples
Download data: CEL
DataSet
Accession:
GDS339
ID:
339
9.
Full record GDS259

Spinal cord injury and regeneration time course: at T9 (RG-U34B)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 11 time sets
Platform:
GPL86
Series:
GSE464
77 Samples
Download data: CEL
DataSet
Accession:
GDS259
ID:
259
10.
Full record GDS63

Spinal cord injury and regeneration time course: at T9 (RG-U34A)

Temporal analysis of molecular mechanisms of spinal cord degeneration and repair. Analyzed spinal cord at thoracic vertebrae T9 at various time points up to 28 days post injury. Mild, moderate and severe injury examined.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 protocol, 11 time sets
Platform:
GPL85
Series:
GSE464
89 Samples
Download data: CEL
DataSet
Accession:
GDS63
ID:
63
11.

Chronic contusion spinal cord injury in rats

(Submitter supplied) Excerpt from a larger study which characterized the transcriptional effects of a spinal cord contusion injury in rats. This is the data from the almost chronic contusion state (35 days) at the injury site (Thoracic 8) - where we saw significant changes in several areas, including cholesterol metabolism genes. Other spinal cord areas (rostral, caudal) and time-points (3 hours, 24 hours, 7 days and 35 days) were analyzed as well and are discussed in our paper and at www.crpf.org/microarray. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1238
Platform:
GPL85
6 Samples
Download data
Series
Accession:
GSE2599
ID:
200002599
12.
Full record GDS1238

Spinal cord contusion

Expression profiling of contused spinal cords of Fischer animals. Spinal cords examined 35 days following contusion at the thoracic 8 segment. Results identify potential targets for therapeutic intervention following spinal cord injury.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 shock sets
Platform:
GPL85
Series:
GSE2599
6 Samples
Download data
DataSet
Accession:
GDS1238
ID:
1238
13.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
14.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
15.

Intrinsic response of thoracic propriospinal neurons to axotomy

(Submitter supplied) Analysis of expression changes in prelabeled laser-microdissected thoracic propriospinal neurons at different times after low-thoracic spinal cord transection in adult rats.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
24 Samples
Download data: CEL
Series
Accession:
GSE20907
ID:
200020907
16.

Microarray analysis of expression of cell death-associated genes in rat spinal cord cells exposed to cyclic tensile stresses in vitro

(Submitter supplied) The application of mechanical insults to the spinal cord results in profound cellular and molecular changes, including the induction of neuronal cell death and altered gene expression profiles. We demonstrated that spinal cord cells undergo cell death in response to cyclic tensile stresses, which were dose- and time- dependent. In addition, we have identified the up regulation of various genes, in particular of the MAPK pathway, which may be involved in this cellular response. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
7 Samples
Download data: CEL, CHP
Series
Accession:
GSE22791
ID:
200022791
17.

Time series gene expression data from adult rat tail MNs following spinal cord transection

(Submitter supplied) Spinal cord injury leads to impaired motor and sensory functions. After spinal cord injury there is a an initial phase of hypo-reflexia followed by a developing hyper-reflexia, often termed spasticity. Previous studies have suggested a relationship between the reappearence of plateau potentials in motor neurons and the development of spasticity after spinalizaion. To understand the moleclar mechanism behind this pheneomona we examined the transcriptional response of the motor neurons after spinal cord injury as it progress over time. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
31 Samples
Download data: CEL
Series
Accession:
GSE19701
ID:
200019701
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