GEO DataSet Links for PMC (Select 3097468) - GEO DataSets

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Items: 2

Select item 2000229341.

Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network

(Submitter supplied) The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. However, it remains unclear whether components of these networks functionally interact and if so, what factors mediate such interactions. Here we show that WD-repeat protein-5 (Wdr5), a core member of the mammalian Trithorax (trxG) complex, positively correlates with the undifferentiated state and is a novel regulator of ES cell self-renewal. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
7 Samples

Download data: BED, TXT, WIG

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Accession:: GSE22934

ID:: 200022934

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000195882.

Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network (2)

(Submitter supplied) The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. It remains unclear whether interactions. Here we show that a core member of the Set/MLL complex, WDrepeat protein-5 (Wdr5), is a novel regulator of self-renewal and partners with Oct4 to maintain an intact transcriptional network and for efficient formation of induced pluripotent stem (iPS) cells. more...