GEO DataSet Links for PMC (Select 3252286) - GEO DataSets

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Links from PMC

Items: 3

Select item 2000311021.

Expression data from GW8510 treatment of pancreatic cells

(Submitter supplied) Expression of insulin in terminally differentiated non-beta pancreatic cell types could be important for treating type-1 diabetes. We observed that the kinase inhibitor GW8510 up-regulated insulin expression in mouse pancreatic alpha cells. Gene-expression profiling and gene-set enrichment analysis of GW8510-treated alpha cells suggested coordinate up-regulation of the p53 pathway, which was further implicated in induction of insulin transcript.

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5502 GDS5503
Platform:: GPL8321
12 Samples

Download data: CEL

Series

Accession:: GSE31102

ID:: 200031102

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 55032.

Small molecule GW8510 effect on pancreatic beta cell

Analysis of pancreatic beta cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5502, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL8321
Series:: GSE31102
6 Samples

Download data: CEL

DataSet

Accession:: GDS5503

ID:: 5503

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 55023.

Small molecule GW8510 effect on pancreatic alpha cell

Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.