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Items: 3

1.

Expression data from GW8510 treatment of pancreatic cells

(Submitter supplied) Expression of insulin in terminally differentiated non-beta pancreatic cell types could be important for treating type-1 diabetes. We observed that the kinase inhibitor GW8510 up-regulated insulin expression in mouse pancreatic alpha cells. Gene-expression profiling and gene-set enrichment analysis of GW8510-treated alpha cells suggested coordinate up-regulation of the p53 pathway, which was further implicated in induction of insulin transcript.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS5502 GDS5503
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE31102
ID:
200031102
2.
Full record GDS5503

Small molecule GW8510 effect on pancreatic beta cell

Analysis of pancreatic beta cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5502, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE31102
6 Samples
Download data: CEL
3.
Full record GDS5502

Small molecule GW8510 effect on pancreatic alpha cell

Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE31102
6 Samples
Download data: CEL
Format
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Send to:

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