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Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

(Submitter supplied) Drosophila Dicer-1 produces microRNAs (miRNAs) from pre-miRNA, whereas Dicer-2 generates small interfering RNAs (siRNAs) from long dsRNA. loquacious (loqs) encodes three Dicer partner proteins, Loqs-PA, Loqs-PB, and, Loqs-PD, generated by alternative splicing. To understand the function of each Loqs isoform, we constructed loqs isoform-specific rescue flies. Loqs-PD promotes siRNA production in vivo by Dicer-2. more...
Organism:
Drosophila melanogaster; Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL9250 GPL9061
24 Samples
Download data: TXT
Series
Accession:
GSE37443
ID:
200037443

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