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Items: 2

1.

Expression data of A939572 SCD1 inhibitor treated ccRCC cells

(Submitter supplied) Presently, there is a deficiency of effective therapies designed to target clear cell renal cell carcinoma (ccRCC), with poor prognosis resulting in patients with advanced disease. Additionally, there is a lack of molecular factors which can be remedially targeted resulting in tumor specific inhibition, and therefore current therapeutic approaches often produce adverse side effects in patients. We identified that Stearoyl-CoA desaturase 1 (SCD1) was consistently overexpressed in patient ccRCC samples, and further investigation of SCD1 as a potential molecular target for ccRCC intervention utilizing a SCD1 inhibitor (A939572) resulted in tumor specific growth inhibition and induction of cell death. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5094
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE41485
ID:
200041485
2.
Full record GDS5094

Stearoyl-CoA desaturase 1 inhibition effect on clear cell renal cell carcinoma cell lines

Analysis of clear cell renal cell carcinoma (ccRCC) cells treated with A939572, a stearoyl-CoA desaturase 1 (SCD1) inhibitor. SCD1 is overexpressed in ccRCC.Results provide insight into the role of SCD1 in the pathogenesis of ccRCC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 cell line sets
Platform:
GPL570
Series:
GSE41485
8 Samples
Download data: CEL

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