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Items: 2

1.

Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity

(Submitter supplied) Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4928
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE37874
ID:
200037874
2.
Full record GDS4928

Acetaminophen effect on thioredoxin reductase 1-null liver

Analysis of liver from hepatocyte-specific, thioredoxin reductase 1 (TrxR1)-null mutants treated with the pro-toxin acetaminophen. The Trx system impacts bioenergetics and drug metabolism. Results provide insight into the role of the Trx system in detoxifying certain xenobiotic challenges.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL8321
Series:
GSE37874
12 Samples
Download data: CEL

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