GEO DataSets

(Submitter supplied) ChIP-seq from mice with DNA binding mutations in Esr1 (KIKO mouse). Estrogen Receptor α (ERα) interacts with DNA, directly, or indirectly via other transcription factors, referred to as “tethering”. Evidence for tethering is based on in vitro studies and a widely used “KIKO” mouse model containing mutations that prevent direct estrogen response element (ERE) DNA-binding. KIKO mice are infertile, due in part to the inability of estrogen (E2) to induce uterine epithelial proliferation. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL11002

5 Samples

Download data: BED, BEDGRAPH

(Submitter supplied) To evaluate the ability of a DNA binding deficient ERa to mediate transcriptional responses in the mouse uterus, ovariectomized mice were injected with 100 ul of saline or 250 ng of estradiol (E2) in 100 ul saline, uterine tissue was collected 2 hours filllowing the injection, and RNA was isolated

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5664

Platform:

GPL4134

12 Samples

Download data: TXT

Analysis of uteri from ovariectomized, EAAE ERα DNA-binding domain mutants collected 2hrs after estradiol injection. The EAAE mouse has an ERα null-like female reproductive tract phenotype. Results provide insight into the ability of EAAE ERα to mediate transcriptional responses in the uterus.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 genotype/variation sets

Platform:

GPL4134

Series:

GSE56423

12 Samples

Download data: TXT