GEO DataSet Links for PMC (Select 4419355) - GEO DataSets

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Items: 2

Select item 2000625171.

Flow-induced Protein Kinase A / CREB pathway acts via BMP signaling to promote AGM hematopoiesis

(Submitter supplied) By chemical modulation of the PKA/CREB and BMP pathways in isolated AGM VE-cadherin+ cells from mid-gestation embryos, we demonstrate that PKA/CREB regulates hematopoietic engraftment and clonogenicity of hematopoietic progenitors and is dependent on secreted BMP ligands through the type I BMP receptor. We used microarray to document upregulation of PKA/CREB-BMP pathway as well as global BMP target upregulation upon PKA/CREB activation.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5813
Platform:: GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE62517

ID:: 200062517

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 58132.

Bone morphogenetic protein 4 and forskolin effect on embryonic AGM VE-cadherin+ cells

Analysis of vascular endothelial (VE)-cadherin+ cells isolated from aorta-gonad-mesonephros (AGM) region of E11.5 embryos then treated with bone morphogenetic protein (BMP) 4, adenylyl cyclase activator forskolin, or both. Results provide insight into the role of BMP signaling in AGM hematopoiesis.