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Items: 2

1.

Flow-induced Protein Kinase A / CREB pathway acts via BMP signaling to promote AGM hematopoiesis

(Submitter supplied) By chemical modulation of the PKA/CREB and BMP pathways in isolated AGM VE-cadherin+ cells from mid-gestation embryos, we demonstrate that PKA/CREB regulates hematopoietic engraftment and clonogenicity of hematopoietic progenitors and is dependent on secreted BMP ligands through the type I BMP receptor. We used microarray to document upregulation of PKA/CREB-BMP pathway as well as global BMP target upregulation upon PKA/CREB activation.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5813
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE62517
ID:
200062517
2.
Full record GDS5813

Bone morphogenetic protein 4 and forskolin effect on embryonic AGM VE-cadherin+ cells

Analysis of vascular endothelial (VE)-cadherin+ cells isolated from aorta-gonad-mesonephros (AGM) region of E11.5 embryos then treated with bone morphogenetic protein (BMP) 4, adenylyl cyclase activator forskolin, or both. Results provide insight into the role of BMP signaling in AGM hematopoiesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 agent sets
Platform:
GPL1261
Series:
GSE62517
8 Samples
Download data: CEL

Supplemental Content

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