GEO DataSet Links for PMC (Select 4644635) - GEO DataSets

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Items: 2

Select item 2000671341.

Expression data from KSL and GMP cells of FLT3/ITD and FLT3/ITD-SmoM2 mice

(Submitter supplied) FLT3/ITD-SmoM2 mice developed rapidly fatal myeloid leukemia compared to FLT3/ITD only mice, suggesting that overactivation of the Hedgehog signaling pathway via SmoM2 can drive myeloid disease progression We used the Affymetrix Mouse 430_2.0 microarray to detail global gene expression responsible for disease progression in sorted bone marrow cells and found that the Hedgehog signaling pathway contributes to disease progression by enhancing FLT3 signaling

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5806
Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE67134

ID:: 200067134

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 58062.

FLT3/ITD-SmoM2 acute myeloid leukemia model: sorted bone marrow cells

Analysis of KSL and GMP cells isolated from bone marrow of Flt3/ITD-SmoM2 transgenics at around 3 months of age when they developed leukemia. Wild-type and FLT3/ITD littermates of the FLT3/ITD-SmoM2 animals were also examined. Results provide insight into the role of SmoM2 in leukemic progression.