GEO DataSet Links for SRA (Select 16075148) - GEO DataSets

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Items: 2

Select item 3055759131.

CM/miR-126Δ/Δ-2

Organism:: Mus musculus

Source name:: bone morrow

Platform:: GPL17021
Series:: GSE184015

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Accession:: GSM5575913

ID:: 305575913

SRA Run Selector

Select item 2001840152.

Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance

(Submitter supplied) Acute myeloid leukemia (AML) harboring inv(16)(p13q22) expresses high levels of miR-126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 expression through aberrant miR-126 transcription and perturbed miR-126 biogenesis via the HDAC8/RAN-XPO5-RCC1 axis. Aberrant miR-126 upregulation promotes survival of leukemia-initiating progenitors and is critical for initiating and maintaining CM-driven AML. more...