GEO DataSet Links for SRA (Select 21931356) - GEO DataSets

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Items: 2

Select item 3051728681.

LIB046510_TRA00182861_S8_quant

Organism:: Homo sapiens

Source name:: CD14+ cells alone

Platform:: GPL18573
Series:: GSE168933

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Accession:: GSM5172868

ID:: 305172868

SRA Run Selector

Select item 2001689332.

Liver Stromal Cells Restrict Macrophage Maturation and Stromal IL-6 Limits the Differentiation of Cirrhosis-linked Macrophages

(Submitter supplied) Liver disease is the cause of approximately two million deaths globally per year, yet effective therapies are lacking. Iterative tissue injury leads to prolonged inflammation, extensive fibrosis, and the possible progression to deadly chronic-end stage disease, such as cirrhosis and hepatocellular carcinoma (HCC). In this study we investigated the ability of liver stromal cells to effect macrophage maturation and differentiation by using an in vitro human stromal-myeloid coculture systems and single cell RNA sequencing.