GEO DataSet Links for SRA (Select 4081764) - GEO DataSets

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Items: 2

Select item 3026356191.

nsRNA_seq_TRPexp_aB_NT

Organism:: Mus musculus

Source name:: Activated primary B cells

Platform:: GPL21626
Series:: GSE99196 GSE99197

Download data: BW

Sample

Accession:: GSM2635619

ID:: 302635619

SRA Run Selector

Select item 2000991962.

Genome Organization Drives Chromosome Fragility [nsRNA-seq]

(Submitter supplied) In this study, we show that evolutionarily conserved chromosome loop anchors bound by CTCF and cohesin are vulnerable to DNA double strand breaks (DSBs) mediated by topoisomerase 2B (TOP2B). Polymorphisms in the genome that redistribute CTCF/cohesin occupancy concomitantly rewire DNA cleavage sites to novel contact domain boundaries. While transcription and replication coupled genomic rearrangements have been well documented, we demonstrate that DSBs at loop anchors are transcription-, replication-, and cell type- independent. more...