GEO DataSet Links for SRA (Select 5646672) - GEO DataSets

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Items: 2

Select item 3031741321.

Uninduced_hepatocyte_6_2b27

Organism:: Mus musculus

Source name:: colony N4 C57/Bl6J background

Platform:: GPL17021
Series:: GSE115301

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Accession:: GSM3174132

ID:: 303174132

SRA Run Selector

Select item 2001153012.

Notch signalling mediates secondary senescence

(Submitter supplied) Oncogene induced senescence (OIS) is a tumour suppressive response to oncogene activation that can be transmitted to neighbouring cells through secreted factors of the senescence associated secretory phenotype (SASP). Using single-cell transcriptomics we observed two distinct endpoints, a primary marked by Ras and a secondary by Notch. We find that secondary senescence in vitro and in vivo requires Notch, rather than SASP alone as previously thought. more...