GEO DataSet Links for SRA (Select 9424500) - GEO DataSets

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Items: 2

Select item 3041736931.

Crispr Control RNAseq rep2

Organism:: Rattus norvegicus

Source name:: N27_Crispr Control RNAseq

Platform:: GPL24688
Series:: GSE140524

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Accession:: GSM4173693

ID:: 304173693

SRA Run Selector

Select item 2001405242.

Mitochondrial Dysfunction Induces Epigenetic Dysregulation by H3K27 Hyperacetylation to Perturb Active Enhancers in Parkinson’s Disease Models

(Submitter supplied) We aim to explore the predominant mitochondrial dysfunctions in PD, with a focus on how altering the histone code contributes to PD pathogenesis. We employ a multidisciplinary approach to convincingly demonstrate that neurotoxicant exposure- and genetic mutation-driven mitochondrial dysfunction share a common mechanism of epigenetic dysregulation. Under both scenarios, lysine 27 acetylation of likely variant H3.2 (H3.2K27ac) increased in dopaminergic neuronal models of PD, thereby opening that region to active enhancer activity via H3K27 hyperacetylation. more...