GEO DataSet Links for SRA (Select 9715599) - GEO DataSets

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Items: 2

Select item 3042276201.

Eed-ETA-rep2

Organism:: Mus musculus

Source name:: mESC

Platform:: GPL24247
Series:: GSE134053

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Sample

Accession:: GSM4227620

ID:: 304227620

SRA Run Selector

Select item 2001340532.

Histone H2AK119 Mono-Ubiquitination is Essential for Polycomb-Mediated Transcriptional Repression

(Submitter supplied) The major function of Polycomb group proteins (PcG) is to maintain transcriptional repression to preserve cellular identity. This is exerted by two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1 and H3K27me3, respectively. Both complexes are essential for development and are deregulated in several types of human tumors. PRC1 and PRC2 exist in different variants and show a complex regulatory cross-talk. more...