Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 8440

1.

Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease

(Submitter supplied) Background A large unmet therapeutic need exists in inflammatory bowel diseases (IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a complete IL-6/IL-6R blockade is limited by profound immunosuppression. Evidence has emerged, that chronic pro-inflammatory activity of IL-6 is mainly mediated by trans-signalling via a complex of IL-6 bound to soluble IL-6R engaging the gp130 receptor without the need of membrane bound IL6R. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL20301 GPL21290
176 Samples
Download data: CSV, XLSX
Series
Accession:
GSE171770
ID:
200171770
2.

A gene set signature for the risk of progression in IgM MGUS to Waldenström Macroglobulinemia by microarray of B cells and plasma cells

(Submitter supplied) IgM monoclonal gammopathy of undetermined significance (IgM MGUS) is an early precursor stage of the rare lymphoma Waldenström Macroglobulinemia (WM). Although comparative gene expression studies on WM, IgM MGUS, and normal B cells identified several genes differently expressed, reliable predictors of progression from IgM MGUS to WM have not yet been identified. We performed a microarray study on CD19+ and CD138+ cells of WM vs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
105 Samples
Download data: CEL
Series
Accession:
GSE171739
ID:
200171739
3.

Skin responses in Atlantic salmon post-smolts during exposure to Tenacibaculum finnmarkense

(Submitter supplied) Tenacibaculum finnmarkense is a novel Gram-negative, aerobic bacterial strain causing skin ulcers in Atlantic salmon. This is an emerging pathogen, which may cause serious problems to aquaculture. The study was designed to compare the life stages (smolt and posmolt) and to assess effects of environment (fresh and brackis water) on the course of disease and salmon responses to the pathogen.
Organism:
Salmo salar
Type:
Expression profiling by array
Platform:
GPL28080
105 Samples
Download data: TXT
Series
Accession:
GSE171699
ID:
200171699
4.

COVID-19 tissue atlases reveal SARS-COV-2 pathology and cellular targets

(Submitter supplied) COVID-19, caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple-organ failure, but little is known about its pathophysiology. Here, we generated single-cell atlases of 23 lung, 16 kidney, 15 liver and 18 heart COVID-19 autopsy donor tissue samples, and spatial atlases of 14 lung donors. Integrated computational analysis uncovered substantial remodeling in the lung epithelial, immune and stromal compartments, with evidence of multiple paths of failed tissue regeneration, including defective alveolar type 2 differentiation and expansion of myofibroblasts and putative TP63+ intrapulmonary basal-like progenitor cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24268 GPL27644
188 Samples
Download data: CSV, H5, TXT
Series
Accession:
GSE171668
ID:
200171668
5.

Contextual cues from cancer cells govern CAF heterogeneity [scRNA-seq]

(Submitter supplied) Cancer cells function as primary architects of the tumor microenvironment. Yet, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
460 Samples
Download data: TXT
Series
Accession:
GSE166479
ID:
200166479
6.

Promoter-wide profiling of DNA methylation in profrontal cortex with patients with bipolar disorder

(Submitter supplied) Bipolar disorder (BD) is a severe mental disorder characterized by repeated mood swings. Although genetic factors with small effect sizes are collectively associated with the pathophysiology of BD, the underlying molecular mechanisms, especially how environmental factors affect the brain genome, remain largely unknown. We revealed neuronal cell-type-specific, pathophysiology-related DNA methylation changes in the prefrontal cortex (PFC) of BD patients, highlighting the importance of the neural epigenome for understanding BD.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL5082
278 Samples
Download data: CEL, MAT
Series
Accession:
GSE137723
ID:
200137723
7.

Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior [ChIP]

(Submitter supplied) Chromatin modifications have essential roles in directing nervous system development and behavior. Drosophila courtship is an ideal model for understanding the relationships between chromatin modifications, gene expression, sexual dimorphisms in neuroanatomy, and reproductive behaviors. These behaviors are largely innate and are under the control of sex determination hierarchy genes doublesex (dsx) and fruitless (fru) that encode sex-specific transcription factors. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17275
216 Samples
Download data: TXT
Series
Accession:
GSE154034
ID:
200154034
8.

Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17275 GPL25244
250 Samples
Download data: CSV, TXT
Series
Accession:
GSE153901
ID:
200153901
9.

Cytosine base editors induce prevalent unwanted out-of-protospacer editing and target-strand editing [Targeted amplicon sequencing]

(Submitter supplied) The Detect-seq provides an unbiased method for genome-wide identification of CBE induced off-targets inside of cells. Purpose: Cytosine base editors (CBEs) have the potential to correct human pathogenic point mutations. However, its genome-wide specificity remains poorly understood, precluding its therapeutic applications. Unbiased tools are urgently needed to comprehensively evaluate CBE off-targets at the genome-wide level. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20795
176 Samples
Download data: XLSX
Series
Accession:
GSE152907
ID:
200152907
10.

Promoter-wide profiling of DNA methylation changes in bipolar disorder

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL5082
294 Samples
Download data: CEL, MAT
Series
Accession:
GSE137921
ID:
200137921
11.

Natural Variation in the Fitness Consequences of Gene Amplification in Wild Saccharomyces cerevisiae Isolates

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Saccharomyces cerevisiae
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL17342
135 Samples
Download data: TXT
Series
Accession:
GSE171587
ID:
200171587
12.

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington Disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL16686
129 Samples
Download data: CEL
Series
Accession:
GSE154141
ID:
200154141
13.

Expression data from Huntington's disease mouse models of striatal astrocytes and microglia

(Submitter supplied) Glial pathology has been implicated as a causal contributor to the dysfunction and death of striatal neurons that characterizes Huntington disease. In this study, we investigated mutant HTT (mHTT)-associated changes in gene expression by both mouse and human striatal astrocytes. Mouse striatal astrocytes were FACS-sorted from two distinct models, R6/2 and zQ175 mice, which respectively express exon1-only truncated or full-length HTT, while human astrocytes were generated from either hESCs expressing full-length mHTT, or fetal striatal glia transduced with exon1-only mHTT. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
111 Samples
Download data: CEL
Series
Accession:
GSE154131
ID:
200154131
14.

Transcription (co)factor and miRNA regulatory landscape of EMT (miRNA-seq)

(Submitter supplied) To investigate the transcriptional remodelling during EMT, we transfected normal murine mammary gland epithelial cells during a 4d TGFbeta treatment individually with siRNA against 46 transcription (co)factors or with 13 mature miRNA, all factors that blocked EMT in a phenotypic microscopy-based EMT screen upon RNAi . As a control, cells were transfected with siRNA/miRNA control followed by 4d TGFbeta treatment (mesenchymal control) or were left untreated (epithelial control). more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
126 Samples
Download data: TXT
Series
Accession:
GSE113038
ID:
200113038
15.

Chromosome Compartments on the Inactive X Guide TAD Formation Independently of Transcription during X-Reactivation

(Submitter supplied) To investigate the dynamics of X-chromosome reactivation, we differentiated mouse embryonic stem cells (ESCs) into neural precursor cells (NPCs) and later reprogrammed them into induced pluripotent stem cells (iPSCs). During the conversions of NPCs into iPSC, we assessed the kinetics of X-chromosome reactivation. We generated allele-specific RNA-seq datasets to assess gene reactivation dynamics, employed ATAC-seq to investigate chromatin opening dynamics and performed in situ Hi-C to explore dynamics of chromosome structure.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL17021
116 Samples
Download data
Series
Accession:
GSE157448
ID:
200157448
16.

TPLL samples and normal T cell fractions

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by array
Platforms:
GPL15520 GPL16791 GPL570
105 Samples
Download data: CEL
Series
Accession:
GSE147933
ID:
200147933
17.

Transcriptional profiling of brain tissues from a Q130 Long Evans Knock-in rat model of Huntington’s disease at 10-, 19- and 24-months of age

(Submitter supplied) Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). A collaboration between the CHDI Foundation and Dr. H.P. Nguyen (huu.nguyen-r7w@ruhr-uni-bochum.de) at Universitat Bochum focused on generating a knock-in rat model of HD that contains expanded CAG repeats inserted within the rat huntingtin gene (Hdh) in order to provide a genetic reconstruction of the human causative mutation within the rat model. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
145 Samples
Download data: TXT
Series
Accession:
GSE169386
ID:
200169386
18.

Protein quality and quantity affect the impact of dietary fat on weight gain and tissue partitioning via host-microbiota changes

(Submitter supplied) Purpose: Dietary fat-driven hyperphagia increase intestinal growth and permeability and create microbial imbalance in the gut. Over-nutrition coupled with increase in intestinal nutrient absorbance capacity then lead to nutrient overload in the liver, visceral adipose tissue followed by ectopic fat deposition with consequential lipotoxicity and inflammation. We investigated how protein quantity (10-30%) and quality (casein and whey) interact with dietary fat (20-55%) to affect these outcomes in adult mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
207 Samples
Download data: TXT
Series
Accession:
GSE167498
ID:
200167498
19.

Epigenome-wide study of brain DNA methylation following acute opioid intoxication

(Submitter supplied) Opioid abuse poses significant risk to individuals in the United States and epigenetic changes are a leading potential biomarker of opioid abuse. Current evidence, however, is mostly limited to candidate gene analysis in whole blood. Here, we provide Illumina HumanMethylationEPIC array data generated in dorsolateral prefrontal cortex tissue from 153 deceased invidiuals: 72 who died of acute opioid intoxication, 53 psychiatric controls, and 28 normal controls. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL21145
153 Samples
Download data: TXT
Series
Accession:
GSE164822
ID:
200164822
20.

Endotype of Allergic Asthma with Airway Obstruction in Urban Children

(Submitter supplied) In the first decade of life, high-asthma risk urban children develop stable phenotypes of respiratory health versus disease that link early life environmental exposures to childhood allergic sensitization and asthma. Moreover, unique patterns of nasal gene expression demonstrate how specific molecular pathways underlie distinct respiratory phenotypes, including allergic and non-allergic asthma.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
353 Samples
Download data: CSV
Series
Accession:
GSE145505
ID:
200145505
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=100:500[Number%20of%20Samples]|query=1|qty=1176|blobid=MCID_6073f1392a88f538b8752bad|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center