GEO DataSets

(Submitter supplied) The purpose of this analysis is to analyze the changes that occur in microRNAs contained in exosomes released from cancer cells in the tumor hypoxic environment of esophageal squamous cell carcinoma(ESCC). We used microarrays to perform a comprehensive analysis of microRNAs in exosomes released from human ESCC cell lines under normoxic or hypoxic conditions.

Organism:

Homo sapiens; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL21572

4 Samples

Download data: CEL, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL24676 GPL17930

61 Samples

Download data: CEL, TXT

(Submitter supplied) Frontotemporal dementia (FTD) is an incurable group of early-onset dementias that can be caused by deposition of hyperphosphorylated tau in patient brains. However, the mechanisms leading to neurodegeneration remain largely unknown. Here, we combined single-cell analyses of FTD patient brains with a stem cell culture and transplantation model of FTD. We identified disease phenotypes in FTD neurons carrying the MAPT-N279K mutation, which were related to oxidative stress, oxidative phosphorylation and neuroinflammation with an upregulation of the inflammation-associated protein osteopontin (OPN). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17930

18 Samples

Download data: CEL

(Submitter supplied) 47,845 probe-sets were screened, This study compared expression profiles of mesenchymal stem cells derived from the two breed DL and AS and then analyzed the expression profile genes between two different sorts of synovial membrane in each breed.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL16569

72 Samples

Download data: CEL

(Submitter supplied) In order to study the molecular mechanisms of malignant biological behavior in gastric cancer regulated by NCAPD3, GeneChip PrimeView human gene expression array was used to detect differentially expressed genes (DEGs) before and after NCAPD3 knockdown. We used microarrays to detail the effect of NCAPD3 knockdown on gene expression in gastric cancer cell and identified differentially expressed genes during this process.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

6 Samples

Download data: CEL

(Submitter supplied) Aeromedical evacuation (AE) is an important tool for transit of injured patients, but both the hypobaria and hyperoxia associated with AE may contribute to secondary injury. We aimed to examine the effects of these acute exposures on gene expression while avoiding the inflammatory storm that would result from injury and potentially mask underlying causes of AE-related secondary injury. We exposed healthy, young male rats to different levels of hypobaria (4000 ft or 8000 ft eqiv.) and/or hyperoxia (100% oxygen) for different durations of time (5 or 10 h). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL25807 GPL23040

235 Samples

Download data: CEL, TXT

(Submitter supplied) EVs derived from HPCs could affect the progression of S. japonicum-induced fibrosis. Considering the EVs’ cargo, small RNAs account for a large proportion of cargoes in EVs, and act as one of the critical post-transcriptional regulators in cell-to-cell communication. Among them, miRNAs are the most studied and their regulatory roles in host–pathogen interactions are increasingly clear. HPCs are a kind of stem cells with potentially bidirectional differentiation ability and interact with hepatic stellate cells during liver injury. more...

Organism:

Rattus norvegicus; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL19117

6 Samples

Download data: CEL

(Submitter supplied) Leishmania (Viannia) braziliensis is a parasite prevalent in Brazil and associated with tegumentary leishmaniasis (TL), including cutaneous (CL) and mucosal (ML) forms. The mechanisms of pathogenesis of TL are not fully understood, including some factors related to the host and parasite interaction in response to infection, and especially about Leishmania RNA Virus 1 (LRV1), an endosymbiont virus parasitizing Leishmania species, particularly triggers ML. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

9 Samples

Download data: CEL

(Submitter supplied) Several groups reported the correlation between hypermethylation of RASSF1A and aggressiveness or a poor outcome in various pediatric tumors, including Wilms tumor. In addition, it is known that the overexpression of RASSF1A promotes apoptotic cell cycle arrest and reduces the tumorigenicity. In an attempt to identify epigenetic targets related to the biological features of rhabdoid tumor of the kidney (RTK), we analyzed the methylation level of the RASSF1A gene in RTK. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL, CHP

(Submitter supplied) We have analyzed transcriptomic intra-tumor heterogeneity among 2-4 multiregional samples from each of 98 primary colorectal cancers. We investigated the level and prognostic value of intra-tumor heterogeniety of the consensus molecular subtypes, and identified subtypes more robust to heterogeneity based on genes with uniform expression levels across tumor regions.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL33696

286 Samples

Download data: CEL

(Submitter supplied) We observed human colorectal cancer cell lines obtained resistance under treatment, and resistant cells switched back to sensitive state when the treatment is withdrawn. To understand gene expressions change during this process, we performed Affymetrix experiments for parental, R20 (resistant), and W20 (withdrawal treatment) clones for three colorectal cancer cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL24324

27 Samples

Download data: CEL, CHP

(Submitter supplied) The mechanisms of cognitive and learning effects of neonicotinoid pesticides were not fully understood. We examined the effects of acute exposure to a neonicotinoid pesticide, clothianidin (CLO) on gene expression profiles in the cellebellum of male mice at 10 weeks of age.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

4 Samples

Download data: CEL

(Submitter supplied) To identify the gene expression differences in skeletal muscles resulting from conditional knockout of the mineralocorticoid receptor in myofibers and myeloid cells in dystrophin-deficient mdx mice

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20775

9 Samples

Download data: CEL

(Submitter supplied) T-lymphocytes from visceral and subcutaneous white adipose tissue (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused on this subject. Claudin-1 (CLDN1) is a protein involved canonically in Tight Junctions (TJs) and tissue paracellular permeability. We evaluated the gene expression in T lymphocytes from vWAT and sWAT and in the whole adipose depots.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

22 Samples

Download data: CEL

(Submitter supplied) To search the genes which were associated with tuberculosis infecion We used the microarrays to detail the global programme of gene exprssion between with the tuberculosis infecion and without the tuberculosis in monozygous twins

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

4 Samples

Download data: CEL, TXT

(Submitter supplied) Mouse primary hepatocytes (PH) and total livers (TL) prepared from C57Bl6 male adult mice which were fed either a CDAA supplemented cholesterol with glucose and fructose or a CSAA diet during 2 weeks.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

14 Samples

Download data: CEL

(Submitter supplied) Styxl2, a poorly characterized pseudophosphatase, was identified as a transcriptional target of the Jak1-Stat1 pathway during myoblast differentiation in culture. Styxl2 is specifically expressed in vertebrate striated muscles. By gene knockdown in zebrafish or genetic knockout in mice, we found that Styxl2 plays an essential role in maintaining sarcomere integrity in developing muscles. To further reveal the functions of Styxl2 in adult muscles, we generated two inducible knockout mouse models: one with Styxl2 being deleted in mature myofibers to assess its role in sarcomere maintenance, and the other in adult muscle satellite cells (MuSCs) to assess its role in de novo sarcomere assembly. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

12 Samples

Download data: CEL, CHP

(Submitter supplied) NOT PROVIDED; REQUESTED

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL23038

8 Samples

Download data: CEL

(Submitter supplied) Transcranial Electrical Stimulation has therapeutic effects on different diseases, including epilepsy. Particularly, Transcranial Focal Stimulation (TFS) has anticonvulsive and antiepileptogenic effects. Nevertheless, the mechanisms and therapeutic targets that induced these effects remain ellusive. We aimed to screen the genetic expression in the cerebral cortex and the hippocampus of rats after a single seizure and TFS to identify potential targets.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL23040

15 Samples

Download data: CEL, TXT

(Submitter supplied) Transcranial Electrical Stimulation has therapeutic effects on different diseases, including epilepsy. Nevertheless, previous evidence also suggest that TFS could modify protein expression in the healthy brain of rats. We aimed to screen genetic expression in the cerebral cortex and the hippocampus of healthy rats to identify potential targets of therapeutic or adverse effects of TFS.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL22388

9 Samples

Download data: CEL