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Items: 1 to 20 of 237

1.
Full record GDS5879

Pulmonary CDC11c+ cells from young and middle-age animals

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL6885
Series:
GSE71868
8 Samples
Download data
2.
Full record GDS5660

Early postnatal skeletal muscle stem cells: time course

Analysis of myogenic stem cells called satellite cells (mSCs) FACS-sorted from the trunk of Pax3GFP/+ mice at postnatal days 1, 12, and 28, a period when most mSCs are in proliferation and quiescence states. Results provide insight into molecular basis of early postnatal skeletal muscle development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 age, 2 tissue sets
Platform:
GPL1261
Series:
GSE65927
11 Samples
Download data: CEL
DataSet
Accession:
GDS5660
ID:
5660
3.
Full record GDS5624

Epigenetic modifying reagents effect on a progressive hearing loss model: whole cochlea

Analysis of cochlea from 4 wk old DBA/2J males (a model of progressive hearing loss) injected for 8 wks with a combination of epigenetic modifiers l-methionine and valproic acid. Results provide insight into the effect of epigenetic modifications on the molecular mechanisms underlying hearing loss.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 3 protocol sets
Platform:
GPL1261
Series:
GSE62173
16 Samples
Download data: CEL
4.
Full record GDS5818

Normal liver developmental stages: embryonic and postnatal

Analysis of hepatoblasts, immature hepatocytes and hepatocytes from livers at different developmental timepoints (embryonic day 14, embryonic day 18, post-natal day 5, post-natal day 56). Results provide insight into molecular mechanisms underlying normal liver development.
Organism:
Mus musculus
Type:
Expression profiling by array, log2 ratio, 4 age, 3 cell type, 2 development stage sets
Platform:
GPL7202
Series:
GSE65063
11 Samples
Download data: TXT
5.
Full record GDS5438

Lung from cigarette smoke-related chronic obstructive pulmonary disease model: time course

Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 stress sets
Platform:
GPL6885
Series:
GSE52509
12 Samples
Download data
DataSet
Accession:
GDS5438
ID:
5438
6.
Full record GDS5432

Age effect on corneal endothelium

Analysis of corneal endothelium from pediatric (4-11 years old) and adult (53-70 years old) donor corneas. Results provide insight into differential molecular expression between pediatric and adult corneal endothelial cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 age sets
Platform:
GPL11532
Series:
GSE58315
9 Samples
Download data: CEL
7.
Full record GDS5415

Model for Wilms tumor of the kidney: time course

Analysis of kidney tumors from Lin28a transgenics at 5 weeks and 4 months of age. Overexpression of heterochronic regulator Lin28 during kidney development promotes Wilms tumor formation. Results provide insight into the role of Lin28 in Wilms tumor formation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 disease state sets
Platform:
GPL6885
Series:
GSE56323
8 Samples
Download data
8.
Full record GDS5286

Monocyte-derived dendritic cells from young and aged donors

Comparison of dendritic cells (DCs) from young (20 to 27 years) and aged (77 to 87 years) donors. DCs are antigen-presenting cells important in initiating and regulating innate and adaptive immune responses. Results provide insight into the molecular basis of the decline in DC function with age.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL571
Series:
GSE58015
9 Samples
Download data: CEL
9.
Full record GDS4892

Age effect on skeletal muscle precursor cells

Analysis of FACS-sorted CD45-Ter119-Sca-1-CD29+Cxcr4+ skeletal muscle precursor (SMP) cells from young, middle-aged, and old C57BL/6 males. Results provide insight into the molecular mechanisms underlying age-related skeletal muscle and stem cell dysfunction.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 age sets
Platform:
GPL1261
Series:
GSE50821
14 Samples
Download data: CEL
10.
Full record GDS5204

Age effect on normal adult brain: frontal cortical region

Analysis of postmortem neuropathologically normal brain samples from the frontal cortical regions of young, middle aged, normal aged and extremely aged adults. Results provide insight into molecular mechanisms of aging in frontal cortical regions of the brain.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 age, 2 gender sets
Platform:
GPL570
Series:
GSE53890
41 Samples
Download data: CEL
11.
Full record GDS5004

Adult alveolar type 2 and embryonic bipotent progenitor lung cells

Analysis of adult alveolar type (AT) 2 and E18 bipotent progenitor (BP) lung cells. During development, AT1 and AT2 cells arise from a BP; after birth, new AT1 cells derive from rare, long-lived, self-renewing mature AT2 cells. Results provide insight into the molecular basis of AT2 self-renewal.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 cell type sets
Platform:
GPL1261
Series:
GSE49346
6 Samples
Download data: CEL, CHP
12.
Full record GDS5412

Age effect on respiratory epithelium: distal trachea and carina region

Analysis of distal trachea and carina region of young (2 month) and old (14 month) C57Bl/6 females. Aging lungs are associated with a variety of structural and pathologic changes. Results provide insight into molecular mechanisms underlying age-related changes in respiratory epithelium.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL1261
Series:
GSE55162
8 Samples
Download data: CEL
13.
Full record GDS5025

Age and gender effect on brain

Analysis of brain from young (7.5-8.5 months) and old (31-36 months) wildtype males and females. Brains are sexually dimorphic in adults. Results provide insight into the molecular mechanisms associated with brain aging across gender.
Organism:
Danio rerio
Type:
Expression profiling by array, transformed count, 2 age, 2 gender sets
Platform:
GPL1319
Series:
GSE53430
12 Samples
Download data: CEL
14.
Full record GDS5642

Tendon development: embryonic limb tendon cells

Analysis of tendon cells isolated by FACS from forelimbs of embryonic day 11.5, E12.5 and E14.5 scleraxis (Scx)-GFP embryos. Basic helix-loop-helix transcription factor Scx is a specific tendon and ligament marker. Results provide insight into molecular pathways involved in tendon development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 age sets
Platform:
GPL1261
Series:
GSE54207
9 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS5642
ID:
5642
15.
Full record GDS4869

Imatinib mesylate effect on bone marrow hematopoietic cells of chronic myeloid leukemia patients

Analysis of bone marrow hematopoietic cells in chronic myeloid leukemia (CML) patients one month after imatinib mesylate (IM) therapy. CML is caused by expression of the BCR/ABL fusion oncogene. Results provide insight into the molecular consequences of IM blockade of oncoprotein Bcr-Abl in CML.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 10 age, 10 gender, 10 individual, 3 protocol sets
Platform:
GPL570
Series:
GSE33075
27 Samples
Download data: CEL
DataSet
Accession:
GDS4869
ID:
4869
16.
Full record GDS4874

IQGAP2 knockout model of hepatocellular carcinoma: time course

Analysis of liver from IQ-motif containing GTPase-activating protein 2 (IQGAP2) KOs at 6- and 24-months of age. IQGAP2 is a member of a multidomain scaffolding protein family that also includes IQGAP1 and IQGAP3. Results provide insight into a potential tumor suppressive role for IQGAP2 in liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE46646
12 Samples
Download data: CEL
17.
Full record GDS4904

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52550
12 Samples
Download data: CEL
18.
Full record GDS5000

Mechanistic Indicators of Asthma (MICA) cohort: peripheral blood

Analysis of peripheral blood from asthmatic and non-asthmatic children (ages 9 to 13), participants of the MICA study conducted by the EPA from 11/2006 to 01/2007 in Detroit, MI. These results, together with clinical biomarker measurements, may help to differentiate asthmatics from non-asthmatics.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 age, 3 disease state, 2 gender sets
Platform:
GPL570
Series:
GSE35571
131 Samples
Download data: CEL
19.
Full record GDS5270

Infarct volume-variant inbred strains at two developmental stages: cerebral cortex

Analysis of cerebral cortex from C57BL/6J and C3H/J strains at post-natal day 1 and week 11. These strains share similar collateral vessel anatomy but exhibit significantly different infarct volume. Results provide insight into molecular mechanisms modulating infarct volume.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 other, 2 strain sets
Platform:
GPL1261
Series:
GSE46443
12 Samples
Download data: CEL
20.
Full record GDS5001

Allergen inhalation challenge effect on peripheral blood of asthmatic early responders and dual responders

Analysis of blood collected from asthmatics immediately prior to, and two hours after, cat allergen challenge. Some asthmatics are early responders while others are dual (early plus late) responders. Results provide insight into the molecular mechanisms underlying early and dual asthmatic responses.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 10 age, 2 gender, 14 individual, 2 other, 2 protocol sets
Platform:
GPL6244
Series:
GSE40240
28 Samples
Download data: CEL
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