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Items: 1 to 20 of 872722

1.

Astrocytes differentiation is modulated by the NF-KB pathway

(Submitter supplied) We demonstrate that persistent NF-KB activation affects neural progenitor cells-derived astrocytes differentiation
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
26 Samples
Download data: CEL
Series
Accession:
GSE117736
ID:
200117736
2.

Expression data from mouse heart treated with 2-methyl-2-thiazoline

(Submitter supplied) 2-methyl-2-thiazoline preserves left ventricular systolic function and decreases infarct size in heart after ischemia/reperfusion injury with ameliorated oxidative stress. We used microarrays to detail the global program of gene expression underlying cardioprotective effect of 2-methyl-2-thiazoline.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE171821
ID:
200171821
3.

The glucocorticoid receptor coordinates myofiber-selective transcriptional networks

(Submitter supplied) Muscle fibers have the capacity to modulate their size in response to hormones, including glucocorticoids. Their effects are mediated by the ubiquitously expressed glucocorticoid receptor (GR). However, GR-mediated transcriptional regulation in skeletal muscle at physiological glucocorticoid levels remains elusive. Our study reveals an increased expression of numerous anabolic factors in GR-deficient myofibers, and a reduced expression of antianabolic factors, leading to fiber hypertrophy. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE144228
ID:
200144228
4.

Intrapericardial administration of secretomes from endometrial-derived mesenchymal stromal cells: effects on immune-related genes in a porcine model of myocardial infarction

(Submitter supplied) Using a porcine model of acute myocardial infarction, we explored the potential effect of secretomes from endometrial-derived mesenchymal stromal cells (endMSCs) and from IFNγ/TNFα-primed endMSCs on immune-related genes in the infarcted tissue.
Organism:
Sus scrofa
Type:
Expression profiling by array
Platform:
GPL18699
12 Samples
Download data: CEL
Series
Accession:
GSE171740
ID:
200171740
5.

A gene set signature for the risk of progression in IgM MGUS to Waldenström Macroglobulinemia by microarray of B cells and plasma cells

(Submitter supplied) IgM monoclonal gammopathy of undetermined significance (IgM MGUS) is an early precursor stage of the rare lymphoma Waldenström Macroglobulinemia (WM). Although comparative gene expression studies on WM, IgM MGUS, and normal B cells identified several genes differently expressed, reliable predictors of progression from IgM MGUS to WM have not yet been identified. We performed a microarray study on CD19+ and CD138+ cells of WM vs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
105 Samples
Download data: CEL
Series
Accession:
GSE171739
ID:
200171739
6.

Promoter-wide profiling of DNA methylation in profrontal cortex with patients with bipolar disorder

(Submitter supplied) Bipolar disorder (BD) is a severe mental disorder characterized by repeated mood swings. Although genetic factors with small effect sizes are collectively associated with the pathophysiology of BD, the underlying molecular mechanisms, especially how environmental factors affect the brain genome, remain largely unknown. We revealed neuronal cell-type-specific, pathophysiology-related DNA methylation changes in the prefrontal cortex (PFC) of BD patients, highlighting the importance of the neural epigenome for understanding BD.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL5082
278 Samples
Download data: CEL, MAT
Series
Accession:
GSE137723
ID:
200137723
7.

Promoter-wide profiling of DNA hydroxymethylation in prefrontal cortex of healthy controls

(Submitter supplied) Bipolar disorder (BD) is a severe mental disorder characterized by repeated mood swings. Although genetic factors with small effect sizes are collectively associated with the pathophysiology of BD, the underlying molecular mechanisms, especially how environmental factors affect the brain genome, remain largely unknown. We revealed neuronal cell-type-specific, pathophysiology-related DNA methylation changes in the prefrontal cortex (PFC) of BD patients, highlighting the importance of the neural epigenome for understanding BD.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL5082
5 Samples
Download data: CEL, MAT
Series
Accession:
GSE137259
ID:
200137259
8.

Promoter-wide profiling of DNA methylation in human neuroblastoma cells cultured with mood stabilizers.

(Submitter supplied) Bipolar disorder (BD) is a severe mental disorder characterized by repeated mood swings. Although genetic factors with small effect sizes are collectively associated with the pathophysiology of BD, the underlying molecular mechanisms, especially how environmental factors affect the brain genome, remain largely unknown. We revealed neuronal cell-type-specific, pathophysiology-related DNA methylation changes in the prefrontal cortex (PFC) of BD patients, highlighting the importance of the neural epigenome for understanding BD.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL5082
11 Samples
Download data: CEL, MAT
Series
Accession:
GSE137254
ID:
200137254
9.

Expression data from mesenchymal stem and progenitor cells freshly isolated from human bone marrow

(Submitter supplied) Murine models of myeloid neoplasia show how leukemia infiltration alters the mesenchymal stem and progenitor cells to reinforce malignancy at the expense of healthy hematopoiesis. However, little is known about the bone marrow architecture in humans. We used global gene expression analyses to analyze mesenchymal stem and progenitor cells from AML patients and compared with mesenchymal stem and progenitor cells from the non-leukemic donor.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
11 Samples
Download data: CEL, CHP
Series
Accession:
GSE171654
ID:
200171654
10.

Promoter-wide profiling of DNA methylation changes in bipolar disorder

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL5082
294 Samples
Download data: CEL, MAT
Series
Accession:
GSE137921
ID:
200137921
11.

Expression studies familial bilateral macronodular adrenal hyperplasia

(Submitter supplied) The objectives were to determine the molecular mechanisms involved in the development and progression of familial BMAH tumours, and the mechanisms of their inefficient steroidogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
8 Samples
Download data: CEL, XLS
Series
Accession:
GSE171558
ID:
200171558
12.

Expression profiles of TREM-1 high and TREM-1 low expressing monocytes

(Submitter supplied) The expression of Triggering Receptor Expressed on Myeloid cells (TREM)-1 has been described as a predictive marker for anti-Tumor Necrosis Factor (TNF)-α monoclonal antibody (mAb) therapy responsiveness in patients with inflammatory bowel disease (IBD). Here we investigated expression of TREM-1 specifically in CD14+ monocytes in relation to anti-TNF response. The pretreatment TREM-1 expression levels of CD14+ monocytes of Crohn’s disease (CD) patients were predictive of outcome to anti-TNF mAb therapy, with low TREM-1 expression associated with response to anti-TNF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23159
26 Samples
Download data: CEL
Series
Accession:
GSE165522
ID:
200165522
13.

Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4

(Submitter supplied) Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention. Pharmacological inhibition of the bromodomain and extraterminal (BET) family of chromatin adapter proteins has proven effective in this regard, suppressing growth of diverse cancer types mainly through downregulation of the c-MYC oncogene and its downstream transcriptional program. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
18 Samples
Download data: CEL
Series
Accession:
GSE164813
ID:
200164813
14.

Multiple IL-17 family cytokines signaling through IL-17RA drive inflammatory pathways in psoriasis

(Submitter supplied) The IL-23/IL-17 immune axis is of central importance in psoriasis. However, the contribution of IL-17 family cytokines other than IL-17A to drive skin inflammation in psoriasis has not been fully established. To further elucidate the role of individual IL-17 family cytokines in psoriasis, we investigated their expression and localization in psoriasis skin at the mRNA and protein level. Moreover, we investigated the gene expression signatures induced by individual IL-17 family cytokines in human skin ex vivo as well as modulation of responses induced by the combination of IL-17 family cytokines in human keratinocytes by brodalumab, a human monoclonal antibody targeting the IL-17RA, versus the IL-17A blocking antibody ixekizumab. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17692
60 Samples
Download data: CEL, XLSX
Series
Accession:
GSE158448
ID:
200158448
15.

Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Methylation profiling by high throughput sequencing
Platform:
GPL23038
10 Samples
Download data: CEL
Series
Accession:
GSE155021
ID:
200155021
16.

Improved persistence and expanded TPEX formation in Regnase-1 KO CAR T cells is TCF-1-dependent

(Submitter supplied) transcriptional profiling was performed on Regnase-1 KO CAR and Regnase-1 TCF-1 DKO CAR T cells isolated 7days after co-transfer into tumor bearing mice. TCF-1 deficiency in Regnase-1 KO CAR T cells led to reduced long-term persistence and memory-like phenotype.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
10 Samples
Download data: CEL
Series
Accession:
GSE155020
ID:
200155020
17.

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington Disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL16686
129 Samples
Download data: CEL
Series
Accession:
GSE154141
ID:
200154141
18.

Expression data from Huntington's disease mouse models of striatal astrocytes and microglia

(Submitter supplied) Glial pathology has been implicated as a causal contributor to the dysfunction and death of striatal neurons that characterizes Huntington disease. In this study, we investigated mutant HTT (mHTT)-associated changes in gene expression by both mouse and human striatal astrocytes. Mouse striatal astrocytes were FACS-sorted from two distinct models, R6/2 and zQ175 mice, which respectively express exon1-only truncated or full-length HTT, while human astrocytes were generated from either hESCs expressing full-length mHTT, or fetal striatal glia transduced with exon1-only mHTT. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
111 Samples
Download data: CEL
Series
Accession:
GSE154131
ID:
200154131
19.

Expression data from Human Fetal Astrocytes and Neurons transduced with WT and mutant HTT

(Submitter supplied) Glial pathology has been implicated as a causal contributor to the dysfunction and death of striatal neurons that characterizes Huntington disease. In this study, we investigated mutant HTT (mHTT)-associated changes in gene expression by both mouse and human striatal astrocytes. Mouse striatal astrocytes were FACS-sorted from two distinct models, R6/2 and zQ175 mice, which respectively express exon1-only truncated or full-length HTT, while human astrocytes were generated from either hESCs expressing full-length mHTT, or fetal striatal glia transduced with exon1-only mHTT. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
18 Samples
Download data: CEL
Series
Accession:
GSE154128
ID:
200154128
20.

Macrophages in Crohn’s disease creeping fat are predominantly inflammatory and produce calprotectin

(Submitter supplied) Crohn’s disease is characterized by transmural inflammation and therefore the mesenteric immune compartment has gained interest. However, its significance in Crohn’s disease is largely unclear. Macrophages are plastic cells that adapt their phenotype to environmental stimuli resulting in inflammatory and regulatory macrophage subsets. Hence, their distribution can reflect the overall nature of an immune infiltrate. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL24324
22 Samples
Download data: CEL
Series
Accession:
GSE148233
ID:
200148233
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