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Items: 1 to 20 of 1514388

1.

The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer’s disease vulnerable neurons.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL21626
36 Samples
Download data: BW
Series
Accession:
GSE203368
ID:
200203368
2.

The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer’s disease vulnerable neurons [RNA-seq_invivo]

(Submitter supplied) Neurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer’s disease. We used a data-driven functional genomics approach to model ECII neurons in silico that led us to the prediction that the proto-oncogene DEK is a driver of tau pathology in these neurons. In order to understand the function of DEK in vulnerable neurons, we modulated its expression in ECII neurons in vitro and in vivo in the mouse. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
10 Samples
Download data: CSV
Series
Accession:
GSE203366
ID:
200203366
3.

The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer’s disease vulnerable neurons [RNA-seq_invitro]

(Submitter supplied) Neurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer’s disease. We used a data-driven functional genomics approach to model ECII neurons in silico that led us to the prediction that the proto-oncogene DEK is a driver of tau pathology in these neurons. In order to understand the function of DEK in vulnerable neurons, we modulated its expression in ECII neurons in vitro and in vivo in the mouse. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: CSV
Series
Accession:
GSE203365
ID:
200203365
4.

The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer’s disease vulnerable neurons [chromatin]

(Submitter supplied) Neurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer’s disease. We used a data-driven functional genomics approach to model ECII neurons in silico that led us to the prediction that the proto-oncogene DEK is a driver of tau pathology in these neurons. In order to understand the function of DEK in vulnerable neurons, we modulated its expression in ECII neurons in vitro and in vivo in the mouse. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL21626
14 Samples
Download data: BW
Series
Accession:
GSE203364
ID:
200203364
5.

Immune system modulation by the adjuvants Poly (I:C) and Montanide ISA 720

(Submitter supplied) We investigated the immune phenotypes induced by Poly (I:C) and Montanide ISA 720 in the context of mice immunization with a recombinant protein based on the Plasmodium vivax circumsporozoite protein sequence.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
15 Samples
Download data: TXT
Series
Accession:
GSE203218
ID:
200203218
6.

RNA sequencing of ipsilateral cortex after transient focal ischemia in mice

(Submitter supplied) We report the application of Illumina paired-end RNA-seq approach for transcriptome of brain tissue in mice. By removing sequence-dependent bias and amplification noise using UMI-tools. The mapped reads of each sample were assembled using StringTie. After the final transcriptome was generated, StringTie and edgeR was used to estimate the expression levels of all transcripts. By obtaining a total of million paired-end reads of sequence from cerebral cortex tissue, we generated transcriptome profiles of mouse ischemic cortex in sham, 24 h after focal ischemia, 28 d after focal ischemia, with or without neuron-specific knockdown of TIPARP, respectively. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
18 Samples
Download data: TXT
Series
Accession:
GSE131712
ID:
200131712
7.

Characterizing a role for HNRNPA2B1 during normal myogenesis

(Submitter supplied) The RNA localization mechanisms in muscle are incompletely known however numerous RNA binding proteins and RNA aggregate into higher order amyloid-like assemblies in degenerative muscle disease. Here we assign a role for the RNA binding protein hnRNPA2B1, heterogeneous RNA binding protein A2/B1, in normal myogenesis. Loss of hnRNPA2/B1 impairs muscle differentiation in vitro. hnRNPA2B1 binds to the 3’UTR of select myogeneic transcripts distinct from other RNA-binding proteins during muscle differentiation. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL19057
6 Samples
Download data: BED, BW
Series
Accession:
GSE106553
ID:
200106553
8.

High-throughput RNA Sequencing of BMDM of Mus musculus stimulated by C. auris or C. albicans

(Submitter supplied) Candida auris has been globally recognized as a multidrug-resistant human fungal pathogen that contributes for the worldwide occurrence of nosocomial outbreaks. It has been reported that C. auris was able to avoid neutrophil attack, suggestive of an impaired innate immune response. Whether C. auris evades the innate immune recognition of BMDM (bone marrow derived macrophage) remains poorly understood, and as for well-known Candida species -C. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
18 Samples
Download data: TXT
Series
Accession:
GSE203508
ID:
200203508
9.

PGC-1α isoform heterodimerization restricts transcription factor docking and limits metabolic adaptations in skeletal muscle

(Submitter supplied) The PGC-1a gene is expressed as several transcriptional coactivator variants that regulate numerous adaptive processes. These include thermogenesis, hepatic metabolism, neuroprotection, and skeletal muscle adaptation to exercise training. To support such diverse functions, PGC-1 isoform expression and activation are under tight tissue- and context-specific control. Notably, PGC-1 isoforms generated by alternative gene promoter usage, and splicing are highly induced in skeletal muscle upon exercise. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: CSV, TSV
Series
Accession:
GSE203299
ID:
200203299
10.

Caveolae-mediated endocytosis of VLDL-sized emulsion particles in macrophages requires NPC1 and STARD3 for further lysosomal processing

(Submitter supplied) Triglyceride-rich lipoproteins and their remnants contribute to atherosclerosis, possibly by carrying remnant cholesterol and/or by exerting a pro-inflammatory effect on macrophages. Nevertheless, little is known about how macrophages process triglyceride-rich lipoproteins. We show that uptake by macrophages of VLDL-sized emulsion particles is dependent on the enzyme lipoprotein lipase via its C-terminal domain. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23479
9 Samples
Download data: RDATA, TXT
Series
Accession:
GSE203250
ID:
200203250
11.

HDAC6 deacetylates IDH1 to regulate the homeostasis of hematopoietic stem/progenitor cells

(Submitter supplied) In order to further explore the mechanism by which increased 5hmC inhibits expansion of LSK cells from Hdac6-/- murine primary BM cells, we performed RNA sequencing (RNA-seq) analysis using LSK cells isolated from Hdac6-/- and WT mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: TXT
Series
Accession:
GSE203239
ID:
200203239
12.

The expression levels of mRNAs between miR-124-3p knockdown group and negative control group in mouse retina at postnatal day 9

(Submitter supplied) Although the miR-124a-3p knockdown mouse exhibited neuronal dysfunction and dysmaturation by disinhibition of Lhx2, its downstream responses in mouse retinal development after birth were still relatively deficient at the transcriptome level. In our previous study, miR-124-3p exhibited a significantly increasing trend after birth, and its related pathways predicted by bioinformatics analysis were associated with biological processes that may play crucial roles in mouse retinal development. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
4 Samples
Download data: XLS
Series
Accession:
GSE200915
ID:
200200915
13.

mRNA microarray of aortae from 10-week male Fbn1mgR/mgR and wild-type mice [10-week_mRNA]

(Submitter supplied) Thoracic aortic aneurysms (TAA) in Marfan syndrome, caused by fibrillin-1 mutations, are characterized by elevated cytokines and fragmentated elastic laminae in the aortic wall. This study explored whether and how specific fibrillin-1-regulated miRNAs mediate inflammatory cytokine expression and elastic laminae degradation in TAA. miRNA expression profiling at early and late TAA stages using a severe Marfan mouse model (Fbn1mgR/mgR) revealed a spectrum of differentially regulated miRNAs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL20258
8 Samples
Download data: CEL
Series
Accession:
GSE199284
ID:
200199284
14.

microRNA microarray of aortae from 10-week male Fbn1mgR/mgR and wild-type mice [10-week_miRNA]

(Submitter supplied) Thoracic aortic aneurysms (TAA) in Marfan syndrome, caused by fibrillin-1 mutations, are characterized by elevated cytokines and fragmentated elastic laminae in the aortic wall. This study explored whether and how specific fibrillin-1-regulated miRNAs mediate inflammatory cytokine expression and elastic laminae degradation in TAA. miRNA expression profiling at early and late TAA stages using a severe Marfan mouse model (Fbn1mgR/mgR) revealed a spectrum of differentially regulated miRNAs. more...
Organism:
synthetic construct; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL21572
8 Samples
Download data: CEL
Series
Accession:
GSE199283
ID:
200199283
15.

microRNA microarray of aortae from 4-week male Fbn1mgR/mgR and wild-type mice [4-week_miRNA]

(Submitter supplied) Thoracic aortic aneurysms (TAA) in Marfan syndrome, caused by fibrillin-1 mutations, are characterized by elevated cytokines and fragmentated elastic laminae in the aortic wall. This study explored whether and how specific fibrillin-1-regulated miRNAs mediate inflammatory cytokine expression and elastic laminae degradation in TAA. miRNA expression profiling at early and late TAA stages using a severe Marfan mouse model (Fbn1mgR/mgR) revealed a spectrum of differentially regulated miRNAs. more...
Organism:
synthetic construct; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL21572
8 Samples
Download data: CEL
Series
Accession:
GSE199282
ID:
200199282
16.

RNA-Seq of XBP1S and ATF6N cardiomyocytes

(Submitter supplied) To characterize transcriptome changes uopn XBP1S and ATF6N overexpression in maturing cardiomyocytes
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: CSV, TXT
Series
Accession:
GSE197965
ID:
200197965
17.

HDAC1/2 is indispensable for mouse and bovine ZGA via regulating distribution of H3K27ac and H3K4me3

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Bos taurus; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24247 GPL26012
42 Samples
Download data
Series
Accession:
GSE182555
ID:
200182555
18.

HDAC1/2 is indispensable for mouse and bovine ZGA via regulating distribution of H3K27ac and H3K4me3 [ChIP-seq]

(Submitter supplied) Zygotic genome activation (ZGA) is an impressed biological event following fertilization during early embryo development. Precise reprogramming of epigenetic modifications (e.g. histone H3 lysine 27 acetylation, H3K27ac) have been found contribute to safeguard ZGA in zebrafish and Drosophila, but the dynamic of H3K27ac and the underlying regulation mechanism in mammal embryos are still enigmatic yet. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
16 Samples
Download data: BED, BW
Series
Accession:
GSE182554
ID:
200182554
19.

HDAC1/2 is indispensable for mouse and bovine ZGA via regulating distribution of H3K27ac and H3K4me3 [RNA-seq]

(Submitter supplied) Zygotic genome activation (ZGA) is an impressed biological event following fertilization during early embryo development. Precise reprogramming of epigenetic modifications (e.g. histone H3 lysine 27 acetylation, H3K27ac) have been found contribute to safeguard ZGA in zebrafish and Drosophila, but the dynamic of H3K27ac and the underlying regulation mechanism in mammal embryos are still enigmatic yet. more...
Organism:
Bos taurus; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL26012
26 Samples
Download data: TXT
Series
Accession:
GSE182553
ID:
200182553
20.

ChIP-Seq analysis of ATF4 in cardiomyocytes in vivo

(Submitter supplied) We used AAV to overexpress ATF4 in murine cardiomyocytes in vivo and perfomred bioChIP-Seq to profile the chromatin occupancy of the exogenous protein
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: BED, BW
Series
Accession:
GSE179958
ID:
200179958
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