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Items: 1 to 20 of 120653

1.

Single-cell RNA sequencing reveals a role for reactive oxygen species and peroxiredoxins in fatty-acid-induced rat ß-cell proliferation

(Submitter supplied) The functional mass of insulin-secreting pancreatic β cells expands to maintain glucose homeostasis in the face of nutrient excess, in part via replication of existing β cells. To decipher the underlying molecular mechanisms, we assessed β-cell proliferation in isolated rat islets exposed to glucose and oleate or palmitate for 48 h and analyzed the transcriptional response by single-cell RNA sequencing. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
11 Samples
Download data: RDS
Series
Accession:
GSE193857
ID:
200193857
2.

Estradiol-dependent gene expression profile in the amygdala of ovariectomized SHRs

(Submitter supplied) Pre-menopausal women exhibit a lower arterial pressure (AP), a lower sympathetic outflow and a greater baroreceptor reflex than age-matched men. However, AP and subsequent cardiovascular diseases dramatically increases in post-menopausal women. Estrogen level is believed to play a role in the regulation of the basal blood pressure, emotion and hormonal response in the different periods of life of a woman but the molecular mechanisms are still not well understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL22740
9 Samples
Download data: TXT
Series
Accession:
GSE163758
ID:
200163758
3.

Single-cell analysis reveals the progress in skin repair after radiation in rats.

(Submitter supplied) This study aims to compare the cell heterogeneity and mRNA expression between irradiated and non-irradiated rat skin tissues at the single cell level. In this study, the skin was isolated from rats with radiation or non-irradiated rats. Male Sprague Dawley (SD) rats (6 weeks of age) were used. For irradiation, the hair on the gluteal region of the rats was shaved using a razor. The animals were immobilized using adhesive tape on a plastic plate to minimize motion during radiation exposure. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
5 Samples
Download data: MTX, TSV
Series
Accession:
GSE193564
ID:
200193564
4.

Investigation of differentially-expressed microRNAs involved in infected nonunion of the human long bones through microRNA expression profiling

(Submitter supplied) 20 miRNAs were identified as differentially expressed in patients with infected nonunion of long bones, which may facilitate the diagnosis of infected nonunion of long bones.
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL18058
9 Samples
Download data: GPR
Series
Accession:
GSE125289
ID:
200125289
5.

Investigation of differential microRNAs in the exosomes of alcohol-induced H9c2 myocardial cells

(Submitter supplied) We use the illumina high-throughput sequencing technology to identify miRNAs between the exosomes of H9c2 cells with or without alcohol-induced.The H9c2 cells were cultured in serum-free medium and stimulated with ethanol (100 mmol/L) or PBS for 24 h, then collected the exosomes samples from serum-free medium. Exosomes were isolated and extracted by differential centrifugation and detected by electron microscopy, particle size and related marker proteins.In total, 123 differentially expressed miRNAs (12 upregulated and 111 downregulated) were screened by miRNA sequence.
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18694
2 Samples
Download data: TXT
Series
Accession:
GSE193545
ID:
200193545
6.

Comprehensive analysis of circRNA expression profiles in rat cerebral cortex after moderate traumatic brain injury

(Submitter supplied) Background: Traumatic brain injury is a medical event of global concern, and a growing body of research suggests that circular RNA can play very important roles in traumatic brain injury. To explore the functions of more novel and valuable circular RNA in traumatic brain injury response, a moderate traumatic brain injury in rat was established and a comprehensive analysis of circular RNA expression profiles in rat cerebral cortex was done. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
8 Samples
Download data: TXT
Series
Accession:
GSE193521
ID:
200193521
7.

Gene expression profiling of neural stem cells in 3D hydrogels with different stiffness

(Submitter supplied) We report a transcriptome sequencing to identify 3D hydrogel stiffness-dependent genes
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22396
16 Samples
Download data: CSV
Series
Accession:
GSE193194
ID:
200193194
8.

Roux-en-Y gastric bypass and caloric restriction but not gut hormone-based treatments profoundly impact the hypothalamic transcriptome in obese rats

(Submitter supplied) Background: The hypothalamus is an important brain region for the regulation of energy balance. Roux-en-Y gastric bypass (RYGB) surgery and gut hormone-based treatments are known to reduce body weight, but their effects on hypothalamic gene expression and signaling pathways are poorly studied. Methods: Diet-induced obese male Wistar rats were randomized into the following groups: RYGB, sham-operation, sham + body weight-matched (BWM) to the RYGB group, osmotic minipump delivering PYY3-36 (0.1mg/kg/day), liraglutide s.c. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20084
65 Samples
Download data: CSV
Series
Accession:
GSE190218
ID:
200190218
9.

G3bp1-miR-1 axis regulates cardiomyocyte hypertrophy

(Submitter supplied) We examine the role of G3bp1, a RNA binding protein and site specific endoribonuclease in gene expression in isolated neonatal cardiomyocytes. RNAseq data from cardiomyocytes were infected with adenoviruses expressing shRNA against G3bp1 (ad-siG3bp1) or Luciferase (ad-siLUC, control) showed significant decrease in transcript abudnnace of cardiac-enriched genes involved in Calcium handling, contraction, action potential and sacromere function. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20084
6 Samples
Download data: XLSX
Series
Accession:
GSE184441
ID:
200184441
10.

Liver sexual dimorphism in key signaling pathways across the rat life course

(Submitter supplied) Introduction: At the molecular level, cellular aging involves changes in multiple gene pathways, which can produce many aging phenotypes. In the liver, senescence changes lead to impaired hepatic function. We hypothesized that the natural hepatic aging process is driven by sex-dependent mechanisms. Purpose: We studied our well-established model of aging in which we have previously determined aging of metabolism, reproduction and endocrine systems. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
24 Samples
Download data: TXT
Series
Accession:
GSE160153
ID:
200160153
11.

The molecular profile and ability to promote axon regeneration after peripheral nerve injury by Repair Schwann cells is distinctly different from that for developing Schwann cells

(Submitter supplied) Since Schwann cells (SCs) support axonal growth at development as well as after peripheral nerve injury (PNI), developing SCs might be able to promote axon regeneration after PNI. The purpose of the current study was to elucidate the capability of developing SCs to induce axon regeneration after PNI. SC precursors (SCPs), immature SCs (ISCs), repair SCs (RSCs) from injured nerves, and non-RSCs from intact nerves were tested by grafting into acellular region of rat sciatic nerve with crush injury. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
6 Samples
Download data: TXT
Series
Accession:
GSE188399
ID:
200188399
12.

Integrative Transcriptomic and Proteomic Analysis Reveals Mechanisms of Silica-induced Pulmonary Fibrosis in Rats

(Submitter supplied) To explore proteomic and transcriptomic changes in rat model of silicosis, transcriptomic analysis by microarray and tandem mass tags (TMT)-based proteomic analysis were performed to reveal the expression of mRNAs and proteins in lung tissues. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied to analyze the alterated genes and proteins. The integrated analysis was performed between transcriptome and proteome. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL25290
12 Samples
Download data: TXT
Series
Accession:
GSE188520
ID:
200188520
13.

m7G-MeRIP-sequencing in a rat model of hypoxic pulmonary hypertension (HPH)

(Submitter supplied) m7G-MeRIP-sequencing for 6 samples of the HPH (10% fractional inspired oxygen) and the control(N, 21% fractional inspired oxygen) groups.
Organism:
Rattus norvegicus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL22396
12 Samples
Download data: XLSX
Series
Accession:
GSE182054
ID:
200182054
14.

lncRNA-sequencing in a rat model of hypoxic pulmonary hypertension (HPH)

(Submitter supplied) lncRNA sequencing for 6 samples of the HPH (10% fractional inspired oxygen) and the control(N, 21% fractional inspired oxygen) groups.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL22396
6 Samples
Download data: XLSX
Series
Accession:
GSE182042
ID:
200182042
15.

Protocol matters – reproducibility and rigor of DNA methylation data sets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platform:
GPL22396
34 Samples
Download data: COV, TXT
Series
Accession:
GSE164833
ID:
200164833
16.

Protocol matters – reproducibility and rigor of DNA methylation data sets [BiSulfite-seq]

(Submitter supplied) While epigenetics continues to be a burgeoning research area in neuroscience, unaddressed issues related to data reproducibility across laboratories remain. Indeed, separating meaningful experimental changes from background variability is a challenge in epigenomic studies. Genome-wide DNA methylation analysis of hippocampal tissues from wild-type rats across three independent laboratories revealed that seemingly minor protocol differences resulted in significant epigenome profile changes, even in the absence of experimental intervention. more...
Organism:
Rattus norvegicus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL22396
17 Samples
Download data: COV
Series
Accession:
GSE164831
ID:
200164831
17.

Protocol matters – reproducibility and rigor of DNA methylation data sets [RNA-seq]

(Submitter supplied) While epigenetics continues to be a burgeoning research area in neuroscience, unaddressed issues related to data reproducibility across laboratories remain. Indeed, separating meaningful experimental changes from background variability is a challenge in epigenomic studies. Genome-wide DNA methylation analysis of hippocampal tissues from wild-type rats across three independent laboratories revealed that seemingly minor protocol differences resulted in significant epigenome profile changes, even in the absence of experimental intervention. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22396
17 Samples
Download data: TXT
Series
Accession:
GSE164800
ID:
200164800
18.

Genome-wide maps of DNA methylation state in 2-week rat IUGR islets

(Submitter supplied) Intrauterine growth restriction (IUGR) increases the risk of developing type 2 diabetes in adulthood. A rat model of IUGR induced by bilateral uterine artery ligation at day 18 of gestation, which reduces the blood supply and critical substrates to the fetus, was used to assess the alterations of genome-wide DNA methylation in IUGR islets. At 2 weeks of age, pancreatic islets were isolated and genomic DNA were extracted for TruSeq-HELP tagging assay. more...
Organism:
Rattus norvegicus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL22396
12 Samples
Download data: XLSX
Series
Accession:
GSE151684
ID:
200151684
19.

Deciphering the role of 3D genome organization in breast cancer susceptibility

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL18694
19 Samples
Download data
Series
Accession:
GSE184285
ID:
200184285
20.

Deciphering the role of 3D genome organization in breast cancer susceptibility (RNA-Seq)

(Submitter supplied) Cancer risk by environmental exposure is modulated by an individual’s genetics and age at exposure. This age-specific period of susceptibility is referred to as a “Window of Susceptibility” (WOS). Radiation exposures poses a high breast cancer risk for women between the early childhood and young adult stage and is reduced in the mid-30s. Rats have a similar WOS for developing breast cancer. Previous studies have identified a looping interaction between a genomic region in the mammary carcinoma susceptibility Mcs5c locus and a known cancer gene, PAPPA. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
13 Samples
Download data: TXT
Series
Accession:
GSE184284
ID:
200184284
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