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Items: 1 to 20 of 118165

1.

Enhanced glucose metabolism through activation of HIF-1α covers the energy demand in a rat embryonic heart primordium after heartbeat initiation.

(Submitter supplied) The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it remains unclear how intracellular metabolism responds to increased energy demands after heartbeat initiation. In this study, embryos in Wistar rats at embryonic day 10, at which heartbeat begins in rats, were divided into two groups by the heart primordium before and after heartbeat initiation and their metabolic characteristics were assessed. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL15084
6 Samples
Download data: TXT
Series
Accession:
GSE185702
ID:
200185702
2.

Mitochondrial Dysfunction Induces Epigenetic Dysregulation by H3K27 Hyperacetylation to Perturb Active Enhancers in Parkinson’s Disease Models

(Submitter supplied) We aim to explore the predominant mitochondrial dysfunctions in PD, with a focus on how altering the histone code contributes to PD pathogenesis. We employ a multidisciplinary approach to convincingly demonstrate that neurotoxicant exposure- and genetic mutation-driven mitochondrial dysfunction share a common mechanism of epigenetic dysregulation. Under both scenarios, lysine 27 acetylation of likely variant H3.2 (H3.2K27ac) increased in dopaminergic neuronal models of PD, thereby opening that region to active enhancer activity via H3K27 hyperacetylation. more...
Organism:
Rattus norvegicus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL24688
24 Samples
Download data: BW, TXT
Series
Accession:
GSE140524
ID:
200140524
3.

Calcitriol ameliorates damage in high-salt diet-induced hypertension: evidence that mediates communication in the gut–kidney axis

(Submitter supplied) Several studies have established a link between high-salt diet, inflammation, and hypertension. Vitamin D supplementation has shown anti-inflammatory effects in many diseases; gut microbiota is also associated with a wide variety of cardiovascular diseases, but potential role of vitamin D and gut microbiota in high-salt diet-induced hypertension remains unclear. Therefore, we used rats with hypertension induced by a high-salt diet as the research object and analyzed the transcriptome of their tissues (kidney and colon) and gut microbiome to conduct an overall analysis of the gut–kidney axis. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20084
31 Samples
Download data: CSV
Series
Accession:
GSE184844
ID:
200184844
4.

Differentially expressed miRNA in recurrent implantation failure (RIF)

(Submitter supplied) we utilized Exiqon miRCURY™ LNA Array (v18.0, Exiqon, Vedbaek, Denmark) to establish miRNA expression profiles in the endometrial tissues at the time of embryo implantation(day 7 after ovulation) from 8 RIF patients and 10 matched controls. A total of 157 miRNAs exhibited distinct expression patterns in RIF patients as opposed to controls (fold change >2.0 and P-value <0.05).
Organism:
Homo sapiens; Mus musculus; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL18058
18 Samples
Download data: GPR
Series
Accession:
GSE121219
ID:
200121219
5.

DEN-induced rat model reproduces key features of human hepatocellular carcinoma

(Submitter supplied) Using RNA-seq analysis, we study a DEN-induced HCC rat model during fibrosis progression and HCC development with special focus on liver inflammatory microenvironment. RNA-seq results show that DEN-induced liver tumors in rat model share remarkable molecular characteristics with human HCC, especially with HCC associated with high proliferation. In conclusion, our study provides detailed insight into the hepatocarcinogenesis in a commonly used model of HCC, facilitating the future use of this model for preclinical testing.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
40 Samples
Download data: TXT
Series
Accession:
GSE182860
ID:
200182860
6.

miRNA expression profiling and identification of a miRNA regulator for macrophage polarization in the murine alveolar macrophage cell line MH-S.

(Submitter supplied) Using the highly sensitive miRNA array, we screened differentially regulated miRNAs in IL-4-induced M2 macrophages and explored the functions of miR-378a-3p by Gene Ontology and Kyoto Encyclopedia of Genes annotation. Furthermore, the quantitative real-time polymerase chain reaction, western blot and dual luciferase reporter assay results showed that Grb2 is a specific target of miR-378a-3p, which will give new insights in disclosing the mechanism of macrophage polarization.
Organism:
Mus musculus; Homo sapiens; Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL18058
6 Samples
Download data: GPR
Series
Accession:
GSE143740
ID:
200143740
7.

Effective control of neuropathic pain by interrupting C/EBPβ-CLEC7A cross-talk-mediated NLRP3 inflammasome-dependent pyroptosis

(Submitter supplied) Neuropathic pain (NP) is a complex chronic pain due to the nervous system damage or diseases.During NP development and progression, the neuroinflammation has been observed along the pain pathways from the spinal cord to the thalamus and the parietal cortex. It may be caused by the activation of glial cells, especially microglia, with production of cytokines and other inflammatory mediators within the central nervous system (CNS), especially in spinal cord. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL17117
2 Samples
Download data: CEL
Series
Accession:
GSE185278
ID:
200185278
8.

Gene expression profiling of the nucleus accumbens and dorsolateral striatum in a two-hit model combining maternal immune activation and peripubertal stress in rats

(Submitter supplied) Substance use disorders are more prevalent in schizophrenia, worsening its course and prognosis. Here, we used a double-hit rat model, combining maternal immune activation (MIA) and peripubertal stress (PUS), to study cocaine addiction and the underlying neurobehavioral alterations. We injected lipopolysaccharide (LPS) or saline on gestational days 15 and 16 to pregnant rats. Their male offspring were then subjected to unpredictable stress during adolescence. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20084
24 Samples
Download data: XLSX
Series
Accession:
GSE185195
ID:
200185195
9.

Innate immunity-driven cell recruitment in rat autoimmune diabetes

(Submitter supplied) Comparative analysis of the response of wild-type (WT) and Ifnar1 knockout LEW.1WR1 rats to infection with Kilham rat virus (KRV) using the Seq-Well single-cell RNA-Seq method. KRV induces the equivalent of human type I diabetes (T1D) in WT rats.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20084
20 Samples
Download data: TXT
Series
Accession:
GSE176082
ID:
200176082
10.

Gene expression analysis of spleens from virus-infected rats

(Submitter supplied) Comparison of gene expression between wildtype (WT) and Ifnar1 ko rats following Kilham rat virus (KRV) challenge
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20084
12 Samples
Download data: TSV
Series
Accession:
GSE114322
ID:
200114322
11.

Transposon-triggered innate immune response confers cancer resistance to the blind mole rat [array]

(Submitter supplied) Blind mole rats (BMRs) are small rodents, characterized by exceptionally long lifespan (> 21 years) and resistance to both spontaneous and induced tumorigenesis. Here we report that cancer resistance in the BMR is mediated by retrotransposable elements (RTEs). BMR cells and tissues express very low levels of DNA methyltransferase 1 (DNMT1). Upon cell hyperplasia, the BMR genome DNA loses methylation, resulting in activation of RTEs. more...
Organism:
Rattus norvegicus; Homo sapiens; Nannospalax ehrenbergi; Mus musculus
Type:
Methylation profiling by genome tiling array
Platform:
GPL28271
20 Samples
Download data: IDAT
Series
Accession:
GSE181732
ID:
200181732
12.

Profiling the retinal microRNA (miRNA) transcriptomes in a rat model of oxygen-induced retinopathy (OIR) by next-generation sequencing

(Submitter supplied) Purpose: The study aimed to determine the transcriptome profile of retinal miRNA in a Sprague Dawley (SD) rat model of oxygen-induced retinopathy Methods: The newborn rats in OIR group were subjected to daily cycles of 80% oxygen for 21 hours and room air for 3 hours in a customised chamber for 14 days (postnatal day 14, P14), then return to room air for 15 days (postnatal day 29, P29). The newborn rats in sham group were housed in room air for 14 days. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18694
9 Samples
Download data: XLSX
Series
Accession:
GSE104620
ID:
200104620
13.

Profiling the retinal microRNA (miRNA) expression in rodents by Next-Generation Sequencing

(Submitter supplied) Purpose: The study aimed to determine the expression profiles of retinal miRNA from adult Sprague Dawley (SD) rat and C57BL/6 mice. Methods: The profile of retinal miRNA transcriptom from rat (8 weeks old) and mice (8 weeks old) were generated by deep sequencing, in triplicate, using Illumina Hiseq-2500 RNA-seq platform. The sequence reads from all samples were analysed for overall quality, screened for the presence of any contaminants and trimmed accordingly. more...
Organism:
Rattus norvegicus; Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL18694 GPL17021
6 Samples
Download data: CSV
Series
Accession:
GSE104593
ID:
200104593
14.

Understanding the role of miRNA-143 (miR-143) in ischemia-induced retinopathy via RNA transcriptome profiling

(Submitter supplied) To investigate molecular network mediated by miR-143, we analyzed the transcriptome profile of retinas isolated from neonatal pups subjected to either normoxia or oxygen-induced retinopathy (OIR) for 14 days (P14) receiving an intravitreal injection of either scrambled miRNAs (control) or miR-143 mimics. Total RNAs were isolated from the retinas and subjected to RNA-Seq. Analysis of RNA-Seq data identified 122 genes with altered levels between OIR rats received miR-143 and scrambled RNAs (adjusted p<0.05). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
10 Samples
Download data: CSV
Series
Accession:
GSE104588
ID:
200104588
15.

Rattus norvegicus brain tissue samples: Sham-operated vs. Remote limb postconditioning (PostC) and Sham-operated vs. transient middle cerebral artery occlusion (tMCAO)

(Submitter supplied) Transcriptional profiling of miRNAs from rat brain tissues comparing controls (Sham) with ischemic rats (tMCAO) and neuroprotected rats (RLIP) Internal normalization: ischemic core vs. periischemic and ANOVA comparison across three experimental conditions: Sham, tMCAO and RLIP
Organism:
Rattus norvegicus; Rattus rattus
Type:
Non-coding RNA profiling by array
Platform:
GPL30677
18 Samples
Download data: TXT
Series
Accession:
GSE184975
ID:
200184975
16.

Penetrating ballistic brain injury produces acute alterations in sleep and circadian-related genes in the rodent cortex: A preliminary study

(Submitter supplied) We performed transcriptional profiling in an established rodent model of penetrating ballistic brain injury (PBBI) in conjunction with continuous sleep pattern recording of the first 24 hours after injury. 12 adult male Sprague-Daley rats that were randomized to PBBI (n=6) or sham (n=6) groups, animals received a right unilateral frontal PBBI, then were sacrificed after 24 hours of EGG/EMG recording. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
22 Samples
Download data: TXT
Series
Accession:
GSE182360
ID:
200182360
17.

The changes of the nuclear landscape upon stimulation of neuronal cells are dependent on the histone deacetylase HDAC1

(Submitter supplied) Spatial chromatin organization is crucial for transcriptional regulation and might therefore be particularly dynamic in neurons since these terminally differentiated cells dramatically change their transcriptome in response to external stimuli. Here, we show that stimulation of neurons causes condensation of large chromatin domains. We find that this phenomenon is not only induced in rat hippocampal neurons cultured in vitro, but is also present in vivo in amygdala neurons of rats subjected to fear conditioning, and hippocampal neurons of animals subjected to kainate evoked seizures or High-Frequency Stimulation (HFS). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18404
6 Samples
Download data: XLSX
Series
Accession:
GSE166599
ID:
200166599
18.

Genome-wide identification of altered m6A-related transcript profiles for vascular tissue in septic rats

(Submitter supplied) Sepsis is the leading cause of death in hospital intensive care units. Recent studies have shown that N6-methyladenosine (m6A) modification promotes the inflammatory response, and we evaluated the effect of lipopolysaccharide (LPS) on aortic m6A modifications in mRNAs and lncRNAs.
Organism:
Rattus norvegicus
Type:
Methylation profiling by array
Platform:
GPL25916
16 Samples
Download data: TXT
Series
Accession:
GSE158943
ID:
200158943
19.

Urine miRNAs as potential biomarkers for systemic reactions induced by exposure to embedded metal

(Submitter supplied) Many veterans live with military grade heavy metal fragments retained in soft tissue. Retained heavy metal fragments may negatively impact health in various organ systems and can manifest as gastrointestinal, neurocognitive, pulmonary and renal disturbances. As such, a better understanding of the long-term effects of retained metals and identification of biomarkers indicative of detrimental health outcomes would benefit clinical decision making. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20084
178 Samples
Download data: TXT
Series
Accession:
GSE167948
ID:
200167948
20.

Calycosin as a novel PI3K activator reduces inflammation and fibrosis in heart failure through AKT-IKK/STAT3 axis

(Submitter supplied) Aim: Inflammation and fibrosis have been shown to be critical factors in heart failure (HF) progression. Calycosin (Cal) is the major active component of Radix astragali and has been widely used to treat inflammation in clinical practice. However, whether Cal could ameliorate myocardial infarction (MI)-induced inflammation and fibrosis and precise mechanisms remain uncertain. The aim of this study is to explore the role of Cal in HF and to clarify the underlying mechanisms. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14844
9 Samples
Download data: TXT
Series
Accession:
GSE184649
ID:
200184649
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