GEO DataSets

(Submitter supplied) Tricresyl Phosphate (TCP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for TCP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL

(Submitter supplied) Isopropylated Phenol Phosphate (IPP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for IPP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

17 Samples

Download data: CEL

(Submitter supplied) Isodecyl Diphenyl Phosphate (IDDP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for IDDP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL

(Submitter supplied) 2-Ethylhexyl Diphenyl Phosphate (EHDP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for EHDP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

21 Samples

Download data: CEL

(Submitter supplied) tert-Butylphenyl Diphenyl Phosphate (BPDP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for BPDP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

21 Samples

Download data: CEL

(Submitter supplied) 2-Hydroxy-4-methoxybenzophenone (HMB) is an approved Food and Drug Administration (FDA) over-the-counter Category I product considered to be a deterrent to ultraviolet (UV) radiation-induced skin cancer. HMB is used in pharmaceuticals, plastic products, fabric coatings, finishes, and cosmetics. Exposure to HMB occurs through both occupational and consumer routes. HMB is used in skin moisturizing products and sunscreen lotions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL

(Submitter supplied) Triphenyl phosphate (TPHP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for TPHP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL

(Submitter supplied) As part of the West Virginia Chemical Spill research program, NTP evaluated three chemicals that were spilled into the Elk Rever in West Virginia for their ability to cause toxicity or biological changes in a short-term toxicogenomic study

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

151 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

151 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to characterize the potential toxicity and genomic benchmark dose of 4-methylcyclohexylmethanol in liver and kidney of male Harlan Sprague Dawley rats using a 5 day dose-response toxicogenomics study design. The 5 day study is used to quickly identify the dose levels where changes in molecular pathways occur. These dose level where pathway level effects begin to occur have been shown to provide a close approximation of a no effect dose level from more resource intensive guideline toxicological assessments.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

58 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to characterize the potential toxicity and genomic benchmark dose of propylene glycol phenyl etherl in liver and kidney of male Harlan Sprague Dawley rats using a 5 day dose-response toxicogenomics study design. The 5 day study is used to quickly identify the dose levels where changes in molecular pathways occur. These dose level where pathway level effects begin to occur have been shown to provide a close approximation of a no effect dose level from more resource intensive guideline toxicological assessments.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

49 Samples

Download data: CEL

(Submitter supplied) The goal of this study was to characterize the potential toxicity and genomic benchmark dose of crude 4-methylcyclohexylmethanol in liver and kidney of male Harlan Sprague Dawley rats using a 5 day dose-response toxicogenomics study design. The 5 day study is used to quickly identify the dose levels where changes in molecular pathways occur. These dose level where pathway level effects begin to occur have been shown to provide a close approximation of a no effect dose level from more resource intensive guideline toxicological assessments.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

44 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Genome binding/occupancy profiling by array

Platform:

GPL18610

6 Samples

Download data: PAIR

(Submitter supplied) A major event in mammalian male sex determination is the induction of the testis determining factor Sry and its downstream gene Sox9. The current study provides one of the first genome wide analyses of the downstream gene binding targets for SRY and SOX9 to help elucidate the molecular control of Sertoli cell differentiation and testis development. A modified ChIP-Chip analysis using a comparative hybridization was used to identify 71 direct downstream binding targets for SRY and 109 binding targets for SOX9. more...

Organism:

Rattus norvegicus

Type:

Genome binding/occupancy profiling by array

Platform:

GPL18610

3 Samples

Download data: CSV, PAIR

(Submitter supplied) A major event in mammalian male sex determination is the induction of the testis determining factor Sry and its downstream gene Sox9. The current study provides one of the first genome wide analyses of the downstream gene binding targets for SRY and SOX9 to help elucidate the molecular control of Sertoli cell differentiation and testis development. A modified ChIP-Chip analysis using a comparative hybridization was used to identify 71 direct downstream binding targets for SRY and 109 binding targets for SOX9. more...

Organism:

Rattus norvegicus

Type:

Genome binding/occupancy profiling by array

Platform:

GPL18610

3 Samples

Download data: CSV, PAIR

(Submitter supplied) Indole-3-carbinol is used as a dietary supplement and has potential use as a therapeutic agent for the prevention of various types of cancer. While substantial evidence exists that indole-3-carbinol can reduce the risk of cancers induced by several known carcinogens when administered to animals, indole-3-carbinol can also function as an initiator and tumor promoter in certain models. The carcinogenic potential of indole-3-carbinol has not been studied in a 2-year bioassay. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL