GEO DataSets

(Submitter supplied) Cell genesis and synaptic plasticity in the adult brain and spinal cord can be influenced by stress, and enriched environment and physical exercise, which promotes the re-expression in adults of a series of intrinsic and extrinsic factors that may be important to stimulte a cell to re-enter growth mode and thus promote regeneration of the damaged system. We used microarray to identify genes that could explain some possible mechanisms involved in motor function recovery and detail the global programme of gene expression undelying plasticity and regeneration process after a spinal cord injury and identified distict classes of up-regulated and down-regulated genes during this process

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL23040

9 Samples

Download data: CEL, CHP

(Submitter supplied) Traumatic spinal cord injury (SCI) may induce irreversible damage leading to severe incapacity. Molecular mechanisms underlying SCI are not fully understood, preventing the development of novel therapeutic resources. Tamoxifen has demonstrated to be a promising therapy. Our aim was to elucidate the molecular mechanisms involved in the beneficial effect of TMX administered after SCI. We use a rat model of SCI, Tamoxifen was administred intraperitoneal 30 min after injury. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL23040

22 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL22145

152 Samples

Download data: TXT

(Submitter supplied) Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used in the study and treatment of neurological conditions including major depression, stroke, epilepsy, schizophrenia, multiple sclerosis, Parkinson’s, and Alzheimer’s disease, as well as other, non-neurological disorders. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL22145

56 Samples

Download data: TXT

(Submitter supplied) We investigated if developmental hypothyroidism controlled cell signaling in the ventricular zone of the rat brain on postnatal day 2. We performed laser capture microdissection to isolate the ventricular zone in euthyroid (control) and hypothyroid rats. Hypothyroidism was induced by a maternal exposure to the goitrogen propylthiourail (PTU) during pregnancy and lactation.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22396

13 Samples

Download data: CSV

(Submitter supplied) Developmental lead (Pb) exposure results in persistent cognitive/behavioral impairments as well as an elevated risk for developing a variety of diseases in later life. The quality of the environment can modify negative influences from Pb exposure. How the interaction between Pb and quality of the environment influences gene expression pattern in the brain affecting the development treajectory is unexplored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20084

12 Samples

Download data: TSV

(Submitter supplied) Current standards for safe delivery of electrical stimulation to the central nervous system are based on foundational studies which examined post-mortem tissue for histological signs of damage. This set of observations and the subsequently proposed limits to safe stimulation, termed the “Shannon limits,” allow for a simple calculation (using charge per phase and charge density) to determine the intensity of electrical stimulation that can be delivered safely to brain tissue. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL25947

6 Samples

Download data: CLOUPE

(Submitter supplied) Parkinson’s disease (PD) is a degenerative disease with prodromal pathology hypothesized to manifest in lower brainstem regions as well as within peripheral systems. Behaviorally, vocal deficits including soft monotone speech appear early and are present in 90% of PD patients. However, the pathology mediating voice deficits is unknown. The Pink1-/- rat is a mitochondrial dysfunction model of prodromal PD. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14844

7 Samples

Download data: XLSX

(Submitter supplied) Early life adversity has been linked to altered reproductive development in humans, including changes in the timing of pubertal onset and sexual activity. One common form of early life adversity is having limited access to resources. This form of early life adversity can be modeled in rodents using the limited bedding and nesting model (LBN), in which rat dams and pups are placed in a low resource environment from postnatal day (PND) 2 through 9. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14844

24 Samples

Download data: GTF, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19271

59 Samples

Download data: CEL

(Submitter supplied) Bariatric surgeries remain the most effective treatments for sustained weight loss and remission of type 2 diabetes. In addition to decreased body weight and improved glucose regulation, these procedures also dramatically increase secretion of several gut hormones including GLP-1. Despite these benefits, there are deleterious side effects to these procedures that include an increased incidence of iron-deficiency related anemias. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19271

29 Samples

Download data: CEL

(Submitter supplied) Bariatric surgeries remain the most effective treatments for sustained weight loss and remission of type 2 diabetes. In addition to decreased body weight and improved glucose regulation, these procedures also dramatically increase secretion of several gut hormones including GLP-1. Despite these benefits, there are deleterious side effects to these procedures that include an increased incidence of iron-deficiency related anemias. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19271

30 Samples

Download data: CEL

(Submitter supplied) Abstract. Transcriptomes of developing, early postnatal rat hippocampus were compared after gestational and lactational exposure to different environmental chemicals exhibiting endocrine activity (endocrine disrupters) at doses impairing memory in adult offspring: Aroclor 1254 (PCB mixture) and bisphenol A, 5 or 0.5 mg/kg administered in chow, and chlorpyrifos, 3 or 1 mg/kg injected subcutaneously. All three chemicals exhibited a common effect on Sox6, Sox11, Pou2f2/Oct2, and Pou3f2/Brn2 in male hippocampus at the higher dose level. Additional Sox and Pou genes were affected by two treatments. Real time RT PCR in samples not used for transcriptomics confirmed the transcriptomics data and showed a comparable expression change for bisphenol A also at the lower dose. No changes were seen in female hippocampus. In the case of Sox6, gene network analyses indicated that miR-24 may be involved in the sexual dimorphism. This miR, which represses Sox6 and is repressed by estrogen receptor-alpa in other tissues, was downregulated by all chemicals in male but not female hippocampus. Sox6 expression levels of individual hippocampus samples (FPKM) were inversely correlated with expression levels of Pvalb, a downstream target of Sox6 and marker of an interneuron subpopulation, but not with markers of Sox6-independent interneuron subpopulations, Nos1 and 5HT3aR, indicating a selective effect on a hippocampal interneuron subpopulation. Effects on interneuron development are further suggested, in males, by changes in Nrg1 and Erbb4 expression controlling interneuron migration. Our investigation disclosed genes involved in cell-autonomous regulation of developmental processes as potential targets of endocrine disrupters. If corroborated by additional studies, they may serve as markers of early developmental effects in regulatory test development.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

66 Samples

Download data: TXT

(Submitter supplied) Purpose: Eye drop application of PNU-282987, an α7 nAChR agonist, causes regeneration through development of Müller derived progeintor cells (MDPCs) that are generated as a result of signaling from activated retinal pigment epitheilal (RPE) cells . The goals of this study are to examine the transcrptional changes through RNA-seq after treatment with PNU-282987 in mammalian RPE cell culture that lead to the dedifferentation and generation of MDPCs in the adult mammalian retina. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23945

10 Samples

Download data: TXT

(Submitter supplied) Background There are sex-specific differences in the prevalence, symptomology and course of psychiatric disorders. However, preclinical models have primarily used males, such that the molecular mechanisms underlying sex-specific differences in psychiatric disorders are not well established. Methods In this study, we compared transcriptome-wide gene expression profiles in male and female rats within the corticolimbic system, including the cingulate cortex, nucleus accumbens medial shell (NAcS), ventral dentate gyrus and the basolateral amygdala (n=22-24 per group/region). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25947

6 Samples

Download data: MTX, TSV, XLSX

(Submitter supplied) Spinal cord injury disrupts ascending and descending neural signals causing sensory and motor dysfunction below the injury. Neuromodulation with electrical stimulation is used in both clinical and research settings to induce neural plasticity and improve functional recovery following injury. However, the mechanisms by which electrical stimulation affects recovery remain unclear. In this study we examined the effects of cortical electrical stimulation following injury on transcription at several levels of the central nervous system. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

20 Samples

Download data: TXT

(Submitter supplied) Early life stress that is not overwhelming can have an “inoculating” effect that promotes resilience in adulthood. However, the mechanisms underlying stress inoculation are unknown and animal models are lacking. Here we used the limited bedding and nesting (LBN) model of adversity to evaluate stress inoculation of addiction-related phenotypes. In LBN, pups from postnatal day 2–9 and their dams were exposed to a low resource environment. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14844

20 Samples

Download data: GTF, TXT

(Submitter supplied) A fundamental, evolutionarily conserved biological mechanism required for long-term memory formation is rapid induction of gene transcription upon learning in relevant brain areas. For episodic types of memories, two regions undergoing this transcription are the dorsal hippocampus (dHC) and prelimbic (PL) cortex. Whether and to what extent these regions regulate similar or distinct transcriptomic profiles upon learning remains to be understood. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22396

18 Samples

Download data: BW, TXT

(Submitter supplied) Depending on the severity of a CNS injury, in humans as well as in experimental animal models certain degrees of functional recovery are observed. Rodent studies have provided much evidence for underlying anatomical changes involving neurite outgrowth of both spared and axotomized fiber tracts, also referred to as sprouting. Following a thoracic spinal cord injury (SCI) in adult rats, axotomized fibers of the hindlimb corticospinal tract (CST) were found to sprout into the cervical spinal cord at different rostrocaudal levels. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22396

30 Samples

Download data: TXT

(Submitter supplied) IUGR is associated with an increased risk of obesity in offspring, which is likely driven in part by reprogramming of the hypothalamus due to suboptimal nutrition and hypoxia during development. As such, we performed mRNA-seq on whole hypothalamic tissue to identify altered expression of genes in our model of IUGR and to identify major pathways that could be associated with fetal undernutrition near term.

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20084

24 Samples

Download data: TXT