(Submitter supplied) The current concept of epigenetic repression is based on one repressor unit corresponding to one silent gene. This notion, however, cannot adequately explain concurrent silencing of multiple loci observed in large chromosome regions. The long-range epigenetic silencing (LRES) can be a frequent occurrence throughout the human genome. To comprehensively characterize the influence of estrogen signaling on LRES, we analyzed transcriptome, methylome, and estrogen receptor alpha (ESR1)-binding datasets from normal breast epithelia and breast cancer cells.
more...- Organism:
- Homo sapiens; Rattus norvegicus
- Type:
- Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by genome tiling array; Expression profiling by array
- 4 related Platforms
- 12 Samples
Download data: GFF, PAIR, TXT, WIG