txid10116[orgn] AND "strain Wistar Kyoto WKY"[All Fields] - GEO DataSets

(Submitter supplied) The aim of this study is to explore the role of circRNAs in the mechanism of submandibular gland (SMG) dysfunction in hypertension.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL14746
10 Samples

Download data: TXT

Series

Accession:: GSE148752

ID:: 200148752

Analyze with GEO2R

Select item 2001487513.

Analyses of circRNAs and mRNAs profiling in the submandibular gland in hypertension [circRNA]

(Submitter supplied) The aim of this study is to explore the role of circRNAs in the mechanism of submandibular gland (SMG) dysfunction in hypertension.

Organism:: Rattus norvegicus

Type:: Non-coding RNA profiling by array

Platform:: GPL21828
10 Samples

Download data: TXT

Series

Accession:: GSE148751

ID:: 200148751

Analyze with GEO2R

Select item 2001076604.

Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL14745
4 Samples

Download data: TXT

Series

Accession:: GSE107660

ID:: 200107660

Select item 2001076595.

Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [hypothalamus]

(Submitter supplied) Arterial pressure (AP) is lower in pre-menopausal women than in men of similar age. Pre-menopausal women exhibit a lower sympathetic outflow and a greater baroreceptor reflex, however molecular mechanisms for the gender differences of AP regulation are still not well understood. Since the hypothalmus is strongly functionnaly connected to the nucleus tractus solitarius (NTS), a pivotal region of the medulla oblongata for regulating the set-point of AP, we hypothesized that a different neuronal functions at the level of hypothalamus between men and women could contribute to the gender difference in cardiovascular homeostasis. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL14745
2 Samples

Download data: TXT

Series

Accession:: GSE107659

ID:: 200107659

Select item 2001076586.

Gender differences of gene expression profiles in brain cardiovascular centers of WKY rats [nucleus of solitarii tract]

(Submitter supplied) Arterial pressure (AP) is lower in pre-menopausal women than in men of similar age. Pre-menopausal women exhibit a lower sympathetic outflow and a greater baroreceptor reflex, however molecular mechanisms for the gender differences of AP regulation are still not well understood. Since the nucleus tractus solitarius (NTS), a pivotal region of the medulla oblongata for regulating the set-point of AP is strongly associated with the AP level, we hypothesized that a different neuronal functions at the level of the NTS between men and women could contribute to the gender difference in cardiovascular homeostasis. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL14745
2 Samples

Download data: TXT

Series

Accession:: GSE107658

ID:: 200107658

Select item 2000593297.

Inhaled Ozone (O3)-Induces Changes in Serum Metabolomic and Liver Transcriptomic Profiles in Rats

(Submitter supplied) Long-term exposure to particulate air pollutants has been linked to increased incidence of Type 2 Diabetes (T2DM). Recently, we showed that the gaseous pollutant, O3, induced glucose intolerance, and increased serum leptin and epinephrine in Brown Norway rats. In this study, we hypothesized that O3 exposure will cause broad scale changes in metabolic homeostasis involving liver, muscle and adipose tissues, and that serum metabolomic and liver transcriptomic profiling will provide mechanistic insights into pollutant-induced metabolic alterations. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL16985
32 Samples

Download data: CEL

Series

Accession:: GSE59329

ID:: 200059329

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000096948.

Differential susceptibility of Wistar Kyoto and spontaneously hypertensive rats to diesel exhaust particle exposure.

(Submitter supplied) DEP exposure is linked to increases in cardiovascular effects. This effect is enhanced in individuals with pre-existing disease. Animal models of cardiovascular disease are used to study this susceptibility. The heart is rich in mitochondria, which produce high levels of free radicals, leading to inactivation of tricarboxylic acid cycle enzymes. We hypothesized that a 4-wk DEP inhalation would result in strain-related structural impairment of cardiac mitochondria and changes in these enzyme activities in WKY and SHR. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS3689
Platform:: GPL341
16 Samples

Download data: CEL, CHP

Series

Accession:: GSE9694

ID:: 200009694

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 36899.

Diesel exhaust particle effect on healthy animals: heart left ventricle

Analysis of heart left ventricle from healthy animals exposed to diesel exhaust (DE) particles. Spontaneously hypertensive animals also examined. DE is linked to cardiovascular impairment. Results suggest DE exposure produces a hypertensive-like cardiac gene expression pattern in healthy animals.