Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 738

1.

Targeting MYC Transcription with Small Peptide Derived from KSHV Transactivator

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Human gammaherpesvirus 8
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL20301 GPL30065
53 Samples
Download data: BW, TSV
Series
Accession:
GSE173725
ID:
200173725
2.

Targeting MYC Transcription with Small Peptide Derived from KSHV Transactivator (CUT&RUN)

(Submitter supplied) Herpesviruses rely on host cell transcription and translation machineries for replication. Viral proteins thus function to redirect multiple cellular proteins for viral replication. In herpesvirus replicating cells, host cell gene transcription is frequently down-regulated because important transcriptional apparatuses are appropriated by viral transcription factors. Here we show that an evolutionally-shaped viral protein sequence is a great starting material for unique drug development to modulate cellular transcription. more...
Organism:
Human gammaherpesvirus 8; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL30065
15 Samples
Download data: BW
Series
Accession:
GSE173724
ID:
200173724
3.

MicroRNA expression profiling of livers from the conditional doxycyline-regulatable c-Myc-driven liver tumor mouse model during tumor development and regression.

(Submitter supplied) Progressing and regressing liver tumor tissues (depending on the group) were subjected to miRNA profiling to identify the miRNA changes occuring during tumor development and regression. Conditional doxycyline-regulatable c-Myc-driven mice get liver tumors following doxycycline (Dox) withdrawal from their diet. When mice are re-administered Dox through their diet, tumors start to regress.
Organism:
Murid gammaherpesvirus 4; Mus musculus; Murid betaherpesvirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL19715
16 Samples
Download data: TXT
Series
Accession:
GSE152920
ID:
200152920
4.

BK5.ATF3-induced mammary tumors compared to normal mammary glands

(Submitter supplied) Transcriptional profiling of mammary tumors that occur in parous, BK5.ATF3 mice, compared to normal mammary tissue
Organism:
Murid gammaherpesvirus 4; Mus musculus; Murid betaherpesvirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL29478
7 Samples
Download data: GPR
Series
Accession:
GSE162793
ID:
200162793
5.

Expression analysis of microRNAs in INT-HA-induced M2-like macrophages and untreated macrophages (M0)

(Submitter supplied) Using the highly sensitive miRNA microarray, we screened 107 up-regulated microRNAs and 33 down-regulated microRNAs in the INT-HA-induced M2-like macrophages and we explored the functions of these miRNAs in macrophage polarization. The enrichment results indicated that these miRNAs might participate in the process of macrophage polarization. Furthermore, the quantitative real-time polymerase chain reaction results showed that miR-935 may play an important role in M2 macrophage polarization which was activated by INT-HA.
Organism:
Herpesvirus saimiri (strain 11); JC polyomavirus; Macaca mulatta polyomavirus 1; Human alphaherpesvirus 2; Merkel cell polyomavirus; Homo sapiens; Human polyomavirus 1; Human immunodeficiency virus 1; Human betaherpesvirus 6B
Type:
Non-coding RNA profiling by array
Platform:
GPL24594
6 Samples
Download data: GPR
Series
Accession:
GSE110339
ID:
200110339
6.

Differentially expressed microRNAs in the mouse liver with T3 treatment

(Submitter supplied) An improved mechanistic understanding of the thyroid hormone (TH) action on bile acid (BA) synthetic pathway, the major route for cholesterol elimination, will facilitate the identification of novel therapeutic targets for hypercholesterolemia. Here, we show that hepatic miR-378 is positively regulated by TH. Transient overexpression of miR-378 in the liver of mice reduces the serum cholesterol levels, which is accompanied with an upregulation of key enzymes involved in the intrahepatic conversion of cholesterol to BAs. more...
Organism:
Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL20794
1 Sample
Download data: TXT, XLS
Series
Accession:
GSE139961
ID:
200139961
7.

Widespread traces of lytic KSHV in primary effusion lymphoma at single-cell resolution

(Submitter supplied) Cancer cells of primary effusion lymphoma (PEL) often contain both Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). We measured the interplay of human, KSHV, and EBV transcription in a cell culture model of PEL using single-cell RNA sequencing. The data detect widespread trace expression of lytic KSHV genes.
Organism:
Homo sapiens; Human gammaherpesvirus 4; Human gammaherpesvirus 8
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28902
2 Samples
Download data: CSV
Series
Accession:
GSE154900
ID:
200154900
8.

The difference of microRNA profiles among control, normal high density lipoprotein-treated and proflammatory high density lipoprotein-treated endothelial cells

(Submitter supplied) The potential mechanism were successfully illustrated through detecting different expression of microRNAs in between proinflammatory high density lipprotein (pHDL), nomal high density lipprotein (nHDL) and control group, to study whether microRNAs play important roles in the endothelial dysfunction caused by pHDL.
Organism:
JC polyomavirus; Homo sapiens; Rhadinovirus; Human alphaherpesvirus 2; Lymphocryptovirus; Merkel cell polyomavirus; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL29064
3 Samples
Download data: XLS
Series
Accession:
GSE156800
ID:
200156800
9.

Integrative analysis of hepatic microRNA and mRNA to identify potential biological pathways associated with monocrotaline-induced liver injury in mice

(Submitter supplied) In this study, the analysis of miRNA and mRNA expression profiles was used to identify the potential engaged biological signaling pathways involved in Monocrotaline-induced liver injury. There were total 35 hepatic miRNAs differentially expressed in mice treated with Monocrotaline (both 270 mg/kg and 330 mg/kg)
Organism:
Murid gammaherpesvirus 4; Mus musculus; Murid betaherpesvirus 1
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL11202 GPL23853
18 Samples
Download data: GPR, TXT
Series
Accession:
GSE102150
ID:
200102150
10.

miRNA profile in the hippocampus of APP/PS1 transgenic mice

(Submitter supplied) To explore the miRNAs associated with the memory deficits in Alzheimer's disease, we detected the miRNA profiles in the hippocampus of 6-month-old male APPswe/PS1dE9 (APP/PS1) mice and age-matched wild type C57BL/6 mice.
Organism:
Herpesvirus saimiri (strain 11); JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Human polyomavirus 1; Human alphaherpesvirus 2; Human betaherpesvirus 6B; Merkel cell polyomavirus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Macacine alphaherpesvirus 1; Human betaherpesvirus 5; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL21439
6 Samples
Download data: GPR
Series
Accession:
GSE138382
ID:
200138382
11.

Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

(Submitter supplied) The viral non-coding RNA HSUR2 regulates apoptosis by recruiting host microRNAs to host mRNAs encoding apoptotic factors. The mechanism whereby HSUR2 targets specific host mRNAs is unknown. Here we developed iRICC to identify sequences mediating RNA-RNA interactions in vivo between a single RNA of interest and its binding RNAs. Sequences that mediate HSUR2-mRNA interactions identified by iRICC-seq were functionally validated by mutational analyses. more...
Organism:
Callithrix jacchus; Saimiriine gammaherpesvirus 2
Type:
Other
Platform:
GPL26076
6 Samples
Download data: TXT
12.

Comparison of microRNA expression profiles in soft palate muscle of patients with OSAHS and chronic tonsillitis.

(Submitter supplied) The expression profile of miRNAs in soft palate muscle of patients with OSAHS (obstructive sleep apnea/hypopnea syndrome) and chronic tonsillitis was examined using miRNA microarray analysis. Combining with the following real time PCR and bioinformatics analysis, the physiological importance of the miRNA-autophagy interconnection is far more likely to be elucidated.
Organism:
Human alphaherpesvirus 2; JC polyomavirus; Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Macaca mulatta polyomavirus 1; Human polyomavirus 1; Homo sapiens; Rhadinovirus; Human immunodeficiency virus 1; Merkel cell polyomavirus
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
8 Samples
Download data: GPR, TXT
Series
Accession:
GSE99239
ID:
200099239
13.

MicroRNA-mediated suppression of the TGF-β pathway confers transmissible and reversible CDK4/6 inhibitor resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human alphaherpesvirus 1; Cytomegalovirus; Lymphocryptovirus; Macaca mulatta polyomavirus 1; Human immunodeficiency virus 1; Human polyomavirus 1; Human alphaherpesvirus 2; JC polyomavirus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Non-coding RNA profiling by array; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL18573 GPL571 GPL19128
75 Samples
Download data: CEL, TXT
Series
Accession:
GSE117748
ID:
200117748
14.

MicroRNA-mediated suppression of the TGF-ß pathway confers transmissible and reversible CDK4/6 inhibitor resistance (miRNA array)

(Submitter supplied) CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptor (ER)-positive breast cancer, so that defining mechanisms of resistance is a pressing issue. Here, we identify increased CDK6 expression as a key determinant of acquired resistance after exposure to palbociclib in ER-positive breast cancer cells. Increased CDK6 in resistant cells was dependent on TGF-β pathway suppression via miR-432-5p expression. more...
Organism:
Cytomegalovirus; Human polyomavirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Homo sapiens; Human alphaherpesvirus 1; Rhadinovirus; Macaca mulatta polyomavirus 1; Human alphaherpesvirus 2; Lymphocryptovirus
Type:
Non-coding RNA profiling by array
Platform:
GPL19128
9 Samples
Download data: TXT
Series
Accession:
GSE117745
ID:
200117745
15.

An integrative approach identifies direct targets of the late viral transcription complex and an expanded promoter recognition motif in Kaposi’s sarcoma-associated herpesvirus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Human gammaherpesvirus 8; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL25719
17 Samples
Download data: TDF, TXT
Series
Accession:
GSE126603
ID:
200126603
16.

RNA sequencing analysis to identify gene targets of Kaposi's sarcoma herpesvirus (KSHV) ORF24

(Submitter supplied) ORF24 is the core component of a virally encoded transcription complex in KSHV that is active during later stages of infection. ORF24 makes interactions with both promoter DNA and host RNA polymerase II. The aim of this study was to identify the targets of the virally encoded transcription complex by sequencing total RNA from cells that express a mutant ORF24 that does not interact with RNA polymerase II and compare it to RNA from a mutant rescue cell line (WT). more...
Organism:
Human gammaherpesvirus 8; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25719
9 Samples
Download data: TXT
Series
Accession:
GSE126602
ID:
200126602
17.

Genome-wide map of viral transcription factor ORF34 binding in Kaposi's Sarcoma Herpesvirus (KSHV)

(Submitter supplied) We report the mapping of the genome-wide binding sites of a central component of a viral transcription complex from KSHV. We find that ORF34 binds at several locations on the viral genome but observed no detectable binding to the host genome. A majority of binding sites on the viral genome were upstream of known transcription start sites of mapped genes.
Organism:
Human gammaherpesvirus 8; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25719
8 Samples
Download data: TDF
Series
Accession:
GSE126601
ID:
200126601
18.

microRNA responses of LPS and IL-10 stimulated primary human monocyte-derived macrophages over a short time-course

(Submitter supplied) Lipopolysaccharide stimulated primary human monocyte-derived macrophages at 2, 4 and 8hrs, IL-10 at 4hrs, IL-10+LPS at 4hrs
Organism:
Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Rattus norvegicus; Murid gammaherpesvirus 4; Human polyomavirus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
6 Samples
Download data: TXT
Series
Accession:
GSE125572
ID:
200125572
19.

Comparative Analysis of Gammaherpesvirus Circular RNA

(Submitter supplied) Recent studies have identified circular RNAs (circRNAs) expressed from the Epstein-Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) human DNA tu- mor viruses. To gain initial insights into the potential relevance of EBV circRNAs in virus biology and disease, we assessed the circRNAome of the interspecies homologue rhesus macaque lymphocryptovirus (rLCV) in a naturally occurring lymphoma from a simian immunodeficiency virus (SIV)-infected rhesus macaque. more...
Organism:
Human gammaherpesvirus 8; Macacine gammaherpesvirus 4; Macaca mulatta; Murid herpesvirus 68; Homo sapiens; Mus musculus
Type:
Other
Platforms:
GPL26009 GPL25719 GPL26010
10 Samples
Download data: BED
20.

RNA sequencing for KSHV circular RNAs

(Submitter supplied) The purpose was to detect viral circular RNAs from infected cells.
Organism:
Homo sapiens; Human gammaherpesvirus 8
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25719
8 Samples
Download data: BED
Series
Accession:
GSE121756
ID:
200121756
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid10379[Organism]|query=1|qty=85|blobid=MCID_61e5383769a0201d795b1f91|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center