txid10407[Organism] - GEO DataSets

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Select item 2002424481.

Ten-eleven translocation (Tet) methylcytosine dioxygenases dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis

(Submitter supplied) Liver-specific ten-eleven translocation methylcytosine dioxygenases 2 and 3 (Tet2 plus Tet3)-deficient hepatitis B virus (HBV) transgenic mice fail to support viral biosynthesis. The levels of viral transcription and replication intermediates are dramatically reduced. Hepatitis B core antigen (HBcAg) is only observed in a very limited number of pericentral hepatocytes in a pattern that is similar to glutamate-ammonia ligase (Glul), a -catenin target gene. more...

Organism:: Hepatitis B virus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL33735
38 Samples

Download data: FA, TXT

Series

Accession:: GSE242448

ID:: 200242448

PubMed Full text in PMC Similar studies

Select item 2002340152.

Efficacy of antiviral therapy and host-virus interactions visualized using serial liver sampling with fine-needle aspirates

(Submitter supplied) Infection-dependent transcriptional changes and the impact of antiviral therapy on viral replication can be measured in longitudinal human liver biopsies using single-cell RNA sequencing data

Organism:: Hepatitis B virus

Type:: Other

Platform:: GPL32478
12 Samples

Download data: BAM, TSV

Series

Accession:: GSE234015

ID:: 200234015

Select item 2002257163.

A nucleosome switch primes Hepatitis B Virus infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Hepatitis B virus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL33150 GPL24676 GPL30882
42 Samples

Download data: BEDGRAPH, TBI

Series

Accession:: GSE225716

ID:: 200225716

Select item 2002257154.

A nucleosome switch primes Hepatitis B Virus infection [Mnase-Seq]

(Submitter supplied) Chronic hepatitis B virus (HBV) infection is an incurable global health threat capable of causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV establishes an independent chromosome, cccDNA, consisting of the circular viral genome and host histones. The first viral protein expressed, HBx, induces degradation of a host silencing factor to facilitate infection. However, the relationship between cccDNA’s chromatin and early HBx transcription state remains poorly understood. more...

Organism:: Hepatitis B virus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL33150 GPL30882
27 Samples

Download data: BEDGRAPH, TBI

Series

Accession:: GSE225715

ID:: 200225715

Select item 2002124185.

RNA sequences amplified from a HBV-genome-encoding plasmid

(Submitter supplied) We collected sequences amplified from three HBV-genome-encoding plasmids, one wild type and two with predefined point mutations.

Organism:: Hepatitis B virus; blank sample

Type:: Other

Platforms:: GPL30314 GPL32478
42 Samples

Download data: VCF

Series

Accession:: GSE212418

ID:: 200212418

Select item 2002081156.

Effect of two compounds on HBV gene expression in HBV-infected primary human hepatocytes.

(Submitter supplied) HBV gene expression in HBV-infected primary human hepatocytes.

Organism:: Hepatitis B virus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32478
96 Samples

Download data: TSV

Series

Accession:: GSE208115

ID:: 200208115

Select item 2001996537.

Hepatitis B virus core protein is not required for cccDNA transcriptional regulation

(Submitter supplied) Background & Aims: Hepatitis B virus (HBV) infection is a major health burden worldwide and currently there is no cure. The persistence of HBV covalently closed circular DNA (cccDNA) is the major obstacle for antiviral treatment. HBV core protein (HBc) has merged as a promising antiviral target, as it plays important roles in critical steps of viral life cycle. However, whether HBc could regulate HBV cccDNA transcription remains to be illustrated. more...

Organism:: Homo sapiens; Hepatitis B virus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL32090
8 Samples

Download data: BW, TXT

Series

Accession:: GSE199653

ID:: 200199653

PubMed Full text in PMC Similar studies

Select item 2001574518.

Relative DNA methylation and demethylation efficiencies during postnatal liver development regulate hepatitis B virus biosynthesis

(Submitter supplied) HBV transcription and replication increases progressively throughout postnatal liver development with maximal viral biosynthesis occurring at around four weeks of age in the HBV transgenic mouse model of chronic infection. Increasing viral biosynthesis is associated with a corresponding progressive loss of DNA methylation. The loss of DNA methylation is associated with increasing levels of 5-hydroxymethylcytosine (5hmC) residues which correlates with increased liver-enriched pioneer transcription factor Forkhead box protein A (FoxA) RNA levels, a rapid decline in postnatal liver DNA methyltransferase (Dnmt) transcripts and a very modest reduction in Ten-eleven translocation (Tet) methylcytosine dioxygenase expression. more...

Organism:: Mus musculus; Hepatitis B virus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL29102
120 Samples

Download data: FA, TXT

Series

Accession:: GSE157451

ID:: 200157451

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001138799.

Mapping the heterogeneity of histone modifications on hepatitis B virus-DNA using liver needle biopsies obtained from chronically infected patients

(Submitter supplied) Covalently closed circular DNA (cccDNA) forms the basis for replication and persistence of hepatitis B virus (HBV) in the chronically infected liver. We have previously shown through the analysis of de novo HBV infected cell lines that viral transcription is subject to regulation by posttranslational modifications (PTMs) of histone proteins bound to cccDNA. We now report the successful adaptation of this ChIPseq approach for the analysis of fine-needle patient liver biopsy specimens to investigate the role of histone PTMs in chronically HBV-infected patients. more...

Organism:: Homo sapiens; Hepatitis B virus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL15520 GPL24950
179 Samples

Download data: WIG, XLSX

Series

Accession:: GSE113879

ID:: 200113879

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011714210.

Comparative analyses of human saliva and plasma IgG antibody reactivities

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Hepatitis B virus adw/991; human gammaherpesvirus 4; Homo sapiens

Type:: Protein profiling by protein array

Platforms:: GPL25331 GPL25332
105 Samples

Download data: GPR

Series

Accession:: GSE117142

ID:: 200117142

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011714111.

Comparative analyses of human saliva and plasma IgG antibody reactivities [HBV]

(Submitter supplied) Saliva based diagnostics is a rapidly evolving field due to the large potential of saliva and the simple sample collection. A systematic comparison of IgG antibody profiles in saliva and plasma is currently lacking in scientific literature. Our hypothesis is that IgG profiles are equal in blood and saliva. By showing the equality of the profiles and relative IgG antigenic reactivities towards proteins and peptides we provide evidence that plasma IgG reactivities can be inferred from saliva IgG reactivities. more...