txid117571[Organism] - GEO DataSets

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Select item 2002071401.

Real-time quantitative PCR analysis of human astrocytes exposed to pressure-driven flow and/or Direct Current Stimulation in vitro

(Submitter supplied) The objective of this study was to investigate the effect of Direct Current Stimulation (DCS) on the gene expression of human astrocytes (HA). DCS at 0.1 or 1mA was applied to monolayers of HA for 10 minutes. Expression of a set of neuroactive genes was assessed immediately of 1 hour after DCS using RT-qPCR. Because DCS can produce electroosmotic flow and fluid shear stress known to influence cell function, we compared three interventions: pressure-driven flow across the monolayer alone (conP), pressure-driven flow plus DCS (DCS P), and DCS alone with flow blocked (DCS S).

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL32410
140 Samples

Download data: XLSX

Series

Accession:: GSE207140

ID:: 200207140

Select item 2002071332.

Nanostring nCounter Immunology Panel between WT and DRA KO mice Colonic Mucosa

(Submitter supplied) Signifiacntly altered genes releated to immunologfy was compared between DRA KO mice and their WT littermates at baseline in the distal colonic mucosal RNA

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL32407
6 Samples

Download data: RCC

Series

Accession:: GSE207133

ID:: 200207133

Select item 2002070753.

Expression data from recombinant HSP90α (rHSP90α) treated human monocytes

(Submitter supplied) Tumor cells modulate host immunity by secreting extracellular vesicles (EV) and soluble factors in circulation. Their interactions with myeloid cells could lead to the generation of myeloid-derived suppressor cells (MDSC), which strongly inhibit the anti-tumor function of T and NK cells. We demonstrated previously that EV derived from mouse and human melanoma cells induced such immunosuppressive activity via upregulating the expression of programmed cell death ligand 1 (PD-L1) on myeloid cells that was dependent on the heat-shock protein 90a (HSP90a) in EV and on the toll-like receptor (TLR) on myeloid cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
14 Samples

Download data: CEL

Series

Accession:: GSE207075

ID:: 200207075

Select item 2002070564.

Global gene expression of Ad-OSCAR and subsequently 5-ASA treated mice with Control mice

(Submitter supplied) To examine the effects of Oscar and its inhibitor 5-ASA on articular cartilage, we established OSCAR overexpressed chondrocytes with adenovirus and treated 5-ASA subsequently. Gene expression profiling analysis was performed using articular cartilage transcriptomes, with biologic replicates, generated by RNA-seq.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

Download data: TXT

Series

Accession:: GSE207056

ID:: 200207056

Select item 2002070375.

Single-cell TCR sequencing of in vitro peripheral blood cell stimulation in ankylosing spondylitis

(Submitter supplied) Single-cell TCR sequencing of in vitro DCs (DC-C96car) stimulated CD4+ T cell single cell TCR sequencing in ankylosing spondylitis

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
1 Sample

Download data: CSV

Series

Accession:: GSE207037

ID:: 200207037

Select item 2002070026.

Establishment of radioresistant U87MG glioblastoma cell line

(Submitter supplied) To explore factors contributing to radioresistance in GBM, we established GBM radioresistant cell line using U87MG human GBM cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: TXT

Series

Accession:: GSE207002

ID:: 200207002

Select item 2002069567.

eEF1A1 mediates the mechanosensation of NSC differentiation

(Submitter supplied) We report a transcriptome sequencing to identify mechanosensitive genes 12-36 hours after initiating differentiation of adult rat neural stem cells on 2D soft and stiff laminin-coated polyacrylamide gels.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22396
23 Samples

Download data: CSV

Series

Accession:: GSE206956

ID:: 200206956

Select item 2002069478.

RNA sequencing on EphrinB2 overexpression cardiac fibroblasts and vector cardiac fibroblasts within or without induction of osteogenic differentiation in the 7th day.

(Submitter supplied) Purpose: To investigate the function of EphrinB2 in the regulation of osteogenic differentiation of cardiac fibroblasts, we established EphrinB2-overexpressing cardiac fibroblasts and corresponding control group by lentivirus.Methods:Adult cardiac fibroblasts were isolated from 6 to 8-week-aged C57BL/6 mice, passage 1 cardiac fibroblasts plated at a density of 2.5 x 104 cells/cm2 were infected with the EphrinB2-overexpressing or vector lentivirus at an MOI of 20 for 12h, after 48 hours’ infection, osteogenesis was induced using differentiation medium (α-MEM supplied with 10% FBS, 10 mM β-glycerophosphate, 100nM dexamethasone and 50 µg/mL L-ascorbic acid). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: TXT

Series

Accession:: GSE206947

ID:: 200206947

Select item 2002068579.

Small RNA sequencing of lipoproteins (HDL) obtained from germ-free mice and facility matched specific-pathogen free mice.

(Submitter supplied) Plasma was harvested from two cohorts of facility-matched germ free (GF) and specific-pathogen free (SPF) mice at the National Gnotobiotic Rodent Resource Center (NGRRC; North Carolina, USA). Plasma was then fractionated by size-exclusion chromatography using three tandem Superdex200 increase columns (Cytiva). Fractions corresponding with HDL were then pooled and concentrated prior to RNA isolation. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19057
22 Samples

Download data: CSV, TXT

Series

Accession:: GSE206857

ID:: 200206857

Select item 20020668110.

Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation

(Submitter supplied) Primordial follicles are the first class of follicles formed in the mammalian ovary and are comprised of an oocyte surrounded by a layer of squamous pre-granulosa cells. This developmental class remains in a non-growing state until individual follicles activate to initiate folliculogenesis. What regulates the timing of follicle activation and the upstream signals that govern these processes are major unanswered questions in ovarian biology. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
244 Samples

Download data: CSV

Series

Accession:: GSE206681

ID:: 200206681

Select item 20020537811.

RNA sequencing and integrative analysis reveal pathways and hub genes associated with TGFβ1 stimulation on prostatic stromal cells (PrSCs)

(Submitter supplied) To examine the effect of TGFβ1 on prostatic stromal cells, we firstly isolated primary prostatic stromal cells from five benign prostatic hyperplasia sample. Then RNA sequencing and bioinformatics analysis were used to reveal important pathways and hub genes associated with TGFβ1 stimulation on PrSCs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
10 Samples

Download data

Series

Accession:: GSE205378

ID:: 200205378

Select item 20020516212.

Tongue immune compartment analysis reveals spatial macrophage heterogeneity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
42 Samples

Download data: MTX, TSV

Series

Accession:: GSE205162

ID:: 200205162

PubMed

Select item 20020515813.

Tongue immune compartment analysis reveals spatial macrophage heterogeneity [bulk RNA-Seq]

(Submitter supplied) The tongue is a unique muscular organ situated in the oral cavity where it is involved in taste sensation, mastication and articulation. As a barrier organ, which is constantly exposed to environmental pathogens,the tongue isexpected to host animmune cell network ensuringlocal immune defence. However, the composition and the transcriptional landscape of the tongue immune system are currently not completely defined. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
38 Samples

Download data: CSV

Series

Accession:: GSE205158

ID:: 200205158

PubMed

Select item 20020515714.

Tongue immune compartment analysis reveals spatial macrophage heterogeneity [bulk RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE205157

ID:: 200205157

PubMed

Select item 20020360915.

Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival

(Submitter supplied) The random-pattern skin flap is a crucial technique in reconstructive surgery and flap necrosis caused by ischemia/reperfusion injury is a major postoperative complication. Herein, we investigated the mechanism of mitophagy induced by Melatonin (ML) and its effect on the survival of skin flaps. Our results demonstrated that ML could activate mitophagy, ameliorate oxidative stress and alleviate apoptosis in TBHP-stimulated human umbilical vein endothelial cells in vitro. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
9 Samples

Download data: PDF, XLSX

Series

Accession:: GSE203609

ID:: 200203609

PubMed

Select item 20020343216.

Exploring the microbiota pecularity in stool and biopsies of Eosinophilic Granulomatosis with Polyangiitis (EGPA) patients

(Submitter supplied) Comparing bacteriota between EGPA patients and healthy subjects

Organism:: Homo sapiens

Type:: Other

Platform:: GPL15520
45 Samples

Download data: CSV, FASTA, TSV

Series

Accession:: GSE203432

ID:: 200203432

PubMed

Select item 20020329017.

Adenovirus Overexpression of human ApoF in C57BL6/J mice

(Submitter supplied) Background: Non-alcoholic fatty liver disease (NAFLD) affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD, in line with highly prevalent dyslipidemia in this population. Increased plasma triglyceride (TG)-rich lipoprotein (TRL) concentrations, an important risk factor for CVD, are closely linked with hepatic TG content. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
12 Samples

Download data: CEL

Series

Accession:: GSE203290

ID:: 200203290

Select item 20020262518.

Whole-blood transcriptional profiles early predict the presence of coronary atherosclerosis and high-risk plaque features at coronary CT angiography

(Submitter supplied) This study aims at identifying gene expression patterns in the whole blood that could differentiate patients with severe coronary atherosclerosis from subjects without detectable coronary artery disease (CAD), and assess associations of gene expression patterns with plaque features at coronary CT angiography (CCTA). Patients undergoing CCTA for suspected CAD, with no cardiovascular history, were enrolled. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23934
52 Samples

Download data: TXT

Series

Accession:: GSE202625

ID:: 200202625

PubMed

Select item 20020254819.

Activated-memory T cells influence naïve T cell fate: A non-cytotoxic function of human CD8 T cells

(Submitter supplied) T cells are endowed with the capacity to sense their environment including other T cells 48 around them. They do so to set their numbers and activation thresholds. This form of regulation has been well-studied within a given T cell population – i.e., within the naïve or memory pool; however, less is known about the cross-talk between T cell subsets. Here, we tested whether memory T cells interact with and influence surrounding naïve T cells. more...