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Items: 1 to 20 of 15450

1.

RNA Seq analysis of WT vs rv3249c mutant

(Submitter supplied) We report the characterization of an Mtb transcriptional regulator Rv3249c (AlkX). Combined, our results define the primary role of AlkX as a transcriptional repressor of the alkBrubAB operon and suggests the operon contributes to intracellular survival of the pathogen and potential persistence phenotypes.
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32215
6 Samples
Download data: CSV
Series
Accession:
GSE201641
ID:
200201641
2.

Arginine-derived polyketides are ubiquitous signals shaping cross-kingdom microbial interactions

(Submitter supplied) To investigate the effect of bldA deletion on gene expression in Streptomyces iranensis with respect to secondary metabolite cluster genes
Organism:
Streptomyces iranensis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32214
8 Samples
Download data: TSV
Series
Accession:
GSE201630
ID:
200201630
3.

Mycobacterium abscessus HelR interacts with RNA Polymerase to confer intrinsic rifamycin resistance

(Submitter supplied) Using RNA sequencing we show that exposure of M. abscessus to sublethal doses of RIF results in ~25-fold upregulation of Mab_helR; an isogenic deletion mutant of Mab_helR is hypersensitive to RIF and RBT, and over-expression of Mab_helR confers RIF tolerance in M. tuberculosis, implying that Mab_helR constitutes a significant determinant of inducible RIF and RBT resistance.
Organism:
Mycobacteroides abscessus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29518
4 Samples
Download data: XLSX
Series
Accession:
GSE201201
ID:
200201201
4.

Comparison of Corynebacterium glutamicum wild type with C. glutamicum ChrS-Ala245fs

(Submitter supplied) In an evolutionary experiment on high hemin concentrations, a frameshift mutation in the ChrS gene was figured out to be striking in survival at high hemin concentrations (Ala245fs). Apart from high upregulation of heme exporter hrtB, microarrays should reveal further different controlled genes compared to the WT.
Organism:
Pseudomonas putida KT2440; Corynebacterium glutamicum; Bacillus subtilis subsp. subtilis str. 168; Gluconobacter oxydans 621H; Escherichia coli str. K-12 substr. MG1655
Type:
Expression profiling by array
Platform:
GPL32387
3 Samples
Download data: GPR
Series
Accession:
GSE206796
ID:
200206796
5.

A compendium of expression profiles for Corynebacterium glutamicum ATCC13032

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032
Type:
Expression profiling by array
Platform:
GPL29897
1214 Samples
Download data: GPR
Series
Accession:
GSE171302
ID:
200171302
6.

A compendium of expression profiles for Corynebacterium glutamicum ATCC13032 [no raw data]

(Submitter supplied) Transcriptional profiling of C. glutamicum wild-type and mutant strains grown under different conditions.
Organism:
Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032
Type:
Expression profiling by array
Platform:
GPL29897
287 Samples
Download data
Series
Accession:
GSE171301
ID:
200171301
7.

A compendium of expression profiles for Corynebacterium glutamicum ATCC13032 [with raw data]

(Submitter supplied) Transcriptional profiling of C. glutamicum wild-type and mutant strains grown under different conditions.
Organism:
Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032
Type:
Expression profiling by array
Platform:
GPL29897
927 Samples
Download data: GPR, TXT, XLS
Series
Accession:
GSE169361
ID:
200169361
8.

Copra β-mannooligosaccharide utilization by Bifidobacterium adolescentis ATCC 15703

(Submitter supplied) In order to understand gene expression profile of Bifidobacterium adolescentis ATCC 15703, it was grown in minimal media upto late log phase in the presence of β-mannooligosaccharide from copra till OD A600 = 0.800
Organism:
Bifidobacterium adolescentis ATCC 15703; Bifidobacterium adolescentis
Type:
Expression profiling by array
Platform:
GPL30400
8 Samples
Download data: TXT
Series
Accession:
GSE180349
ID:
200180349
9.

Transcriptome of epibiont Saccharibacteria TM7x during establishment of symbiosis on host Schaalia odontolyticus strain XH001

(Submitter supplied) Nanosynbacter lyticus type strain TM7x was the first cultivated member of the broadly prevelent, but poorly udnerstood Candidate Phylum Radiation super-phylum. TM7x was shown to be an obligate epibiont with a host range including Schaalia odontolyticus strain XH001. The process of infecting a naive host goes through multiple phases, from an initial binding and interaction phase we call the initial encounter, to a rapid die off of infected host cells, killing phase, followed by regrowth of the host cells, regrowth phase, and finally a stable symbiosis between the species, stable symbiosis.To obtain a better understanding of the process by which these species establish a stable symbiosis, we measured the transcriptome using RNA sequencing across the course of infection. more...
Organism:
Schaalia odontolytica; Candidatus Nanosynbacter lyticus
Type:
Expression profiling by MPSS
Platforms:
GPL31941 GPL31942
30 Samples
Download data: XLSX
Series
Accession:
GSE196744
ID:
200196744
10.

RNA-seq analysis of various strains of Mycobacterium tuberculosis under normal and acidic stress.

(Submitter supplied) We have performred RNA-seq analysis of WT and ∆phoR Mtb H37Rv under normal and acidic stress, to investigate the role of PhoR in maintaning the pH homoeostasis of bacterium. RNA was extracted from exponentially growing mycobacterial cells in Middlebrook 7H9 media. For acid stress, cells at OD600 of 0.6 were pelleted, washed twice with 7H9 medium buffered with 100 mM MOPS or 2N HCl for pH 7.0 or pH 4.5, respectively, re-suspended in media of indicated pH, and finally the cells were grown further for 2 hours at 37°C. more...
Organism:
Mycobacterium tuberculosis H37Rv
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17280
8 Samples
Download data: TXT
Series
Accession:
GSE180161
ID:
200180161
11.

A multi-omics investigation into the mechanisms of hyper-virulence in Mycobacterium tuberculosis

(Submitter supplied) The result validated the connections between mutations, gene expression and mycobacterial pathogenicity, and identified new possible virulence-associated pathways in M. tuberculosis.
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18768
8 Samples
Download data: TXT
Series
Accession:
GSE203662
ID:
200203662
12.

Iron limitation in M. tuberculosis has broad impact on bacterial metabolism revealing alternative routes to novel therapeutics

(Submitter supplied) Mycobacterium tuberculosis (Mtb), the cause of the human pulmonary disease tuberculosis (TB), contributes to approximately 1.5 million deaths every year. Prior work has established that lipids serve as the primary carbon and energy source for Mtb in vivo and fulfill major roles in Mtb physiology and pathogenesis. We conducted a high-throughput screen to identify novel inhibitors of Mtb survival in its host macrophage. more...
Organism:
Mycobacterium tuberculosis; Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL31944 GPL25317
21 Samples
Download data: TXT
Series
Accession:
GSE196816
ID:
200196816
13.

Mycobacterium tuberculosis transcription factor, EmbR regulates expression of virulence factors that aid in ex vivo and in vivo survival

(Submitter supplied) We report RNAseq analysis of Mycobacterium tuberculosis strain that lack transcription factor EmbR and the isogenic wild type. We identify the genes whose expression is altred by the mutation and show that genes associated with virulende are downregulated in EmbR KO cells.
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27507
4 Samples
Download data: TXT
Series
Accession:
GSE154673
ID:
200154673
14.

PrrA modulation of Mycobacterium tuberculosis response to acidic pH and high chloride levels is critically regulated by serine/threonine protein kinases

(Submitter supplied) The purpose of this study was to understand how prevention of serine/threonine protein kinase (STPK) phosphorylation of PrrA impacts PrrA modulation of M. tuberculosis transcriptional response to acidic pH and high chloride levels.
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17879
8 Samples
Download data: CSV
Series
Accession:
GSE199000
ID:
200199000
15.

PrrA modulation of Mycobacterium tuberculosis response to nitric oxide is critically regulated by serine/threonine protein kinases

(Submitter supplied) The purpose of this study was to understand how prevention of serine/threonine protein kinase (STPK) phosphorylation of PrrA impacts PrrA modulation of M. tuberculosis transcriptional response to nitric oxide.
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17879
8 Samples
Download data: CSV
Series
Accession:
GSE198999
ID:
200198999
16.

PrrA modulates Mycobacterium tuberculosis response to acidic pH and high chloride levels

(Submitter supplied) The purpose of this study was to identify genes that are differentially expressed upon prrA overexpression, to reveal the impact of PrrA on global transcription in acidic pH and/or high chloride conditions.
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17879
16 Samples
Download data: CSV
Series
Accession:
GSE198998
ID:
200198998
17.

PrrA modulates Mycobacterium tuberculosis response to nitric oxide

(Submitter supplied) The purpose of this study was to understand the impact of prrA overexpression on global M. tuberculosis transcriptional response to nitric oxide.
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17879
8 Samples
Download data: CSV
Series
Accession:
GSE198997
ID:
200198997
18.

The lack of the TetR-like repressor gene BCG_2177c (Rv2160A) may help mycobacteria overcome intracellular redox stress and survive longer inside macrophages when surrounded by a lipid environment

(Submitter supplied) We analyzed the genes expressed, or the transcriptome, of bacilli Mycobacterium bovis BCG Pasteur (wtBCG) and a mutant strain obtained by transposition of the gene BCG_ BCG_2177c (mtBCG), cultured in the presence of a lipid mixture (fatty acids/cholesterol) as main carbon source. Using RNAseq we identified a group of genes that provides novel insight regarding the metabolic pathways and transcriptional regulation, and pathogenic features that were influenced by BCG_2177c gene, a TetR-like repressor, during the lipid metabolism in slow-growing mycobacteria that could be extrapolated to other members of the MTBC.
Organism:
Mycobacterium tuberculosis variant bovis BCG
Type:
Expression profiling by high throughput sequencing
Platform:
GPL29423
8 Samples
Download data: TXT
Series
Accession:
GSE175579
ID:
200175579
19.

Modulation of cAMP levels by a conserved actinobacteria phosphodiesterase enzyme reduces antimicrobial tolerance in mycobacteria

(Submitter supplied) The second messenger, cyclic-AMP (cAMP) is conserved across all taxa of life. It is involved in propagating the signal from environmental stimuli and converting it into a response. In bacteria such as M. tuberculosis (Mtb), P. aeruginosa, V. cholerae and B. pertussis, cAMP has been implicated in virulence, regulation of metabolism and gene expression. Cyclic AMP signalling in mycobacteria is especially complex – with 16 enzymes that produce cAMP in Mtb alone. more...
Organism:
Mycolicibacterium smegmatis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28938
6 Samples
Download data: CSV
Series
Accession:
GSE157084
ID:
200157084
20.

Transcriptomic changes associated with deletion of Rv3143 from Mycobacterium tuberculosis H37Rv in relation to wild-type strain grown in 7H9/OADC medium

(Submitter supplied) RNA-Seq results accompanying submission of a manuscript: "The orphan response regulator Rv3143 modulates the activity of the NADH dehydrogenase complex (Nuo) in Mycobacterium tuberculosis via protein-protein interactions" describing the function of the Rv3143 "orphan" response regulator of the two-component signal transduction systems family, which enable mycobacterial cells to quickly adapt and adequately respond to adverse environmental conditions encountered at various stages of host infection. more...
Organism:
Mycobacterium tuberculosis H37Rv
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26169
6 Samples
Download data: TXT
Series
Accession:
GSE193950
ID:
200193950
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